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We began analyzing https://link.springer.com/article/10.1007/s13277-013-1220-2, but it redirected us to https://link.springer.com/article/10.1007/s13277-013-1220-2. The analysis below is for the second page.

Title[redir]:
Diagnostic value of pleural interleukin 17 and carcinoembryonic antigen in lung cancer patients with malignant pleural effusions | Tumor Biology
Description:
Interleukin 17 (IL-17) has been found to be increased in some human cancers; however, the possible implication of IL-17 in regulating antitumor responses in lung cancer patients with malignant pleural effusions (MPE) remains to be elucidated. This study aimed to investigate the diagnostic value of pleural IL-17 and carcinoembryonic antigen (CEA) in MPE and benign pleural effusions (BPE). Pleural effusion samples from 108 patients were classified on the basis of diagnosis as MPE (n = 56) and BPE (n = 52). The concentration of IL-17 was determined by enzyme-linked immunosorbent assay (ELISA). The CEA levels were also determined in all patients. A significant difference was observed in the levels of CEA (P < 0.01) between MPE and BPE. The concentration of IL-17 in MPE was significantly higher compared to that in BPE (P < 0.01). With a cutoff point of 15.7 pg/ml, IL-17 had a sensitivity of 76.8 % and a specificity of 80.8 % for differential diagnosis. The combined detection of IL-17 and CEA had a sensitivity of 96.4 % and a specificity of 92.3 % to distinguish MPE from BPE. The combined detection of IL-17 and CEA may be more valuable in the differential diagnosis between MPE and BPE.

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Keywords {🔍}

article, pleural, pubmed, google, scholar, malignant, cas, cancer, effusion, effusions, diagnostic, interleukin, cells, antigen, carcinoembryonic, lung, patients, mpe, diagnosis, tuberculous, med, tumor, bpe, access, privacy, cookies, content, zhang, human, cea, wang, central, publish, research, search, zhan, differentiation, yang, res, immunol, nanjing, data, information, log, journal, biology, september, xiuwei, benign, levels,

Topics {✒️}

month download article/chapter transforming growth factor-beta diagnostic molecular biomarkers enzyme-linked immunosorbent assay benign pleural effusions il-6-stat3 signaling pathway li-ke yu xiu-wei zhang malignant pleural effusion pleural effusion samples pleural effusion control full article pdf related subjects malignant pleural effusions malignant pleural effusions human cd4+ il-17-producing tuberculous pleural effusion promote tumor growth privacy choices/manage cookies interleukin 17-producing human human tumor environments lung cancer patients tuberculous pleural effusions thoracoscopic pleural biopsies pleural lavage fluid article xu cd4+cd 25+ foxp3+ pleural effusion carcinoembryonic antigen level european economic area regulating antitumor responses significantly higher compared check access emel'ianov mn kol'tsov ki abou chaz mb lap-dependent mechanism o'shea jj instant access conditions privacy policy cd4+cd25+ regulatory nonspecific pleuritis/fibrosis thorac cardiovasc surg abd el rahman helper cells tuberculous exudative pleurisy annu rev immunol clin cancer res pleural interleukin 17 accepting optional cookies

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         description:Interleukin 17 (IL-17) has been found to be increased in some human cancers; however, the possible implication of IL-17 in regulating antitumor responses in lung cancer patients with malignant pleural effusions (MPE) remains to be elucidated. This study aimed to investigate the diagnostic value of pleural IL-17 and carcinoembryonic antigen (CEA) in MPE and benign pleural effusions (BPE). Pleural effusion samples from 108 patients were classified on the basis of diagnosis as MPE (n = 56) and BPE (n = 52). The concentration of IL-17 was determined by enzyme-linked immunosorbent assay (ELISA). The CEA levels were also determined in all patients. A significant difference was observed in the levels of CEA (P < 0.01) between MPE and BPE. The concentration of IL-17 in MPE was significantly higher compared to that in BPE (P < 0.01). With a cutoff point of 15.7 pg/ml, IL-17 had a sensitivity of 76.8 % and a specificity of 80.8 % for differential diagnosis. The combined detection of IL-17 and CEA had a sensitivity of 96.4 % and a specificity of 92.3 % to distinguish MPE from BPE. The combined detection of IL-17 and CEA may be more valuable in the differential diagnosis between MPE and BPE.
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