
DOI . ORG {
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Title[redir]:
Germline loss diminishes somatic mitochondria but confers preservation of respiratory function during aging and hypothermia | Journal of Biosciences
Description:
Reproductive status influences metabolism and health across the lifespan in diverse ways, and mitochondrial function plays a critical role in mediating this relationship. Using the Caenorhabditis elegans germline ablation model, we investigated the impact of germline stem cell (GSC) loss on mitochondrial dynamics and respiratory function. Our results show that GSC loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and upon exposure to hypothermic stress, correlating with enhanced survival. We found that the transcription factor NHR-49/PPARα, but not DAF-16/FOXO3A, was essential for preserving mitochondrial function and hypothermia resistance in these long-lived mutants. Together, these findings reveal the impact of germline signals on somatic mitochondrial health and underscore the intricate relationship between reproductive fitness and organismal health.
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Keywords {🔍}
pubmed, article, google, scholar, cas, central, mitochondrial, elegans, cell, germline, lifespan, caenorhabditis, aging, reproductive, longevity, sci, supplementary, nature, function, usa, pittsburgh, research, loss, ghazi, survival, cells, regulation, biol, medicine, content, mitochondria, amrit, signals, access, plos, response, life, figure, privacy, cookies, data, information, journal, somatic, respiratory, health, springer, signaling, authors, publish,
Topics {✒️}
germ-line stem cells modulate fatty-acid beta-oxidation month download article/chapter germline stem cell retromer-dependent wnt signaling clark-type oxygen electrode francis rg amrit germ cell absence transcription factor nhr-49/pparα nuclear receptor nhr-49 cell senescence full article pdf germline cells epigenetic age acceleration amrit fr fatty acid composition caenorhabditis elegans oogenesis polycystic ovary syndrome mitochondrial stress response electronic supplementary material mitochondrial stress signaling privacy choices/manage cookies intestinal cells nutrient-sensing pathways article hwang transcription elongation factor caenorhabditis mothers research infrastructure programs preserves mitochondrial activity elegans longevity pathways article journal survival analyses performed blood oxygen tensions mitochondrial dna quantification holds exclusive rights accepted manuscript version somatic mitochondrial health cell death differ reproductive system regulate germline loss european economic area check access restoring lipid homeostasis cushing-haugen kl 2003 tissue-specific activities joo hj sex-specific manner 2017 long-term effects cold adaptation rangos sr
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headline:Germline loss diminishes somatic mitochondria but confers preservation of respiratory function during aging and hypothermia
description:Reproductive status influences metabolism and health across the lifespan in diverse ways, and mitochondrial function plays a critical role in mediating this relationship. Using the Caenorhabditis elegans germline ablation model, we investigated the impact of germline stem cell (GSC) loss on mitochondrial dynamics and respiratory function. Our results show that GSC loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and upon exposure to hypothermic stress, correlating with enhanced survival. We found that the transcription factor NHR-49/PPARα, but not DAF-16/FOXO3A, was essential for preserving mitochondrial function and hypothermia resistance in these long-lived mutants. Together, these findings reveal the impact of germline signals on somatic mitochondrial health and underscore the intricate relationship between reproductive fitness and organismal health.
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