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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s12038-025-00539-x, but it redirected us to https://link.springer.com/article/10.1007/s12038-025-00539-x. The analysis below is for the second page.

Title[redir]:
Germline loss diminishes somatic mitochondria but confers preservation of respiratory function during aging and hypothermia | Journal of Biosciences
Description:
Reproductive status influences metabolism and health across the lifespan in diverse ways, and mitochondrial function plays a critical role in mediating this relationship. Using the Caenorhabditis elegans germline ablation model, we investigated the impact of germline stem cell (GSC) loss on mitochondrial dynamics and respiratory function. Our results show that GSC loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and upon exposure to hypothermic stress, correlating with enhanced survival. We found that the transcription factor NHR-49/PPARα, but not DAF-16/FOXO3A, was essential for preserving mitochondrial function and hypothermia resistance in these long-lived mutants. Together, these findings reveal the impact of germline signals on somatic mitochondrial health and underscore the intricate relationship between reproductive fitness and organismal health.

Matching Content Categories {📚}

  • Education
  • Science
  • Business & Finance

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We're unsure how the site profits.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, mitochondrial, elegans, cell, germline, lifespan, caenorhabditis, aging, reproductive, longevity, sci, supplementary, nature, function, usa, pittsburgh, research, loss, ghazi, survival, cells, regulation, biol, medicine, content, mitochondria, amrit, signals, access, plos, response, life, figure, privacy, cookies, data, information, journal, somatic, respiratory, health, springer, signaling, authors, publish,

Topics {✒️}

germ-line stem cells modulate fatty-acid beta-oxidation month download article/chapter germline stem cell retromer-dependent wnt signaling clark-type oxygen electrode francis rg amrit germ cell absence transcription factor nhr-49/pparα nuclear receptor nhr-49 cell senescence full article pdf germline cells epigenetic age acceleration amrit fr fatty acid composition caenorhabditis elegans oogenesis polycystic ovary syndrome mitochondrial stress response electronic supplementary material mitochondrial stress signaling privacy choices/manage cookies intestinal cells nutrient-sensing pathways article hwang transcription elongation factor caenorhabditis mothers research infrastructure programs preserves mitochondrial activity elegans longevity pathways article journal survival analyses performed blood oxygen tensions mitochondrial dna quantification holds exclusive rights accepted manuscript version somatic mitochondrial health cell death differ reproductive system regulate germline loss european economic area check access restoring lipid homeostasis cushing-haugen kl 2003 tissue-specific activities joo hj sex-specific manner 2017 long-term effects cold adaptation rangos sr

Schema {🗺️}

WebPage:
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         headline:Germline loss diminishes somatic mitochondria but confers preservation of respiratory function during aging and hypothermia
         description:Reproductive status influences metabolism and health across the lifespan in diverse ways, and mitochondrial function plays a critical role in mediating this relationship. Using the Caenorhabditis elegans germline ablation model, we investigated the impact of germline stem cell (GSC) loss on mitochondrial dynamics and respiratory function. Our results show that GSC loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and upon exposure to hypothermic stress, correlating with enhanced survival. We found that the transcription factor NHR-49/PPARα, but not DAF-16/FOXO3A, was essential for preserving mitochondrial function and hypothermia resistance in these long-lived mutants. Together, these findings reveal the impact of germline signals on somatic mitochondrial health and underscore the intricate relationship between reproductive fitness and organismal health.
         datePublished:2025-04-28T00:00:00Z
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      headline:Germline loss diminishes somatic mitochondria but confers preservation of respiratory function during aging and hypothermia
      description:Reproductive status influences metabolism and health across the lifespan in diverse ways, and mitochondrial function plays a critical role in mediating this relationship. Using the Caenorhabditis elegans germline ablation model, we investigated the impact of germline stem cell (GSC) loss on mitochondrial dynamics and respiratory function. Our results show that GSC loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and upon exposure to hypothermic stress, correlating with enhanced survival. We found that the transcription factor NHR-49/PPARα, but not DAF-16/FOXO3A, was essential for preserving mitochondrial function and hypothermia resistance in these long-lived mutants. Together, these findings reveal the impact of germline signals on somatic mitochondrial health and underscore the intricate relationship between reproductive fitness and organismal health.
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      sameAs:https://doi.org/10.1007/s12038-025-00539-x
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         Biomedicine
         Zoology
         Plant Sciences
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                  name:University of Pittsburgh School of Medicine, John G. Rangos Sr. Research Center
                  address:
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               type:PostalAddress
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      name:Andrew P Wojtovich
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            address:
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      name:Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, USA
      name:Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, USA
      name:Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, USA
      name:Vascular Medicine Institute and Center for Metabolism and Mitochondrial Medicine, Department of Medicine, University of Pittsburgh School of Medicine, BST E1240, Pittsburgh, USA
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External Links {🔗}(272)

Analytics and Tracking {📊}

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Libraries {📚}

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Emails and Hosting {✉️}

Mail Servers:

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Name Servers:

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CDN Services {📦}

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