DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Questions
Schema
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://link.springer.com/article/10.1007/s12032-013-0517-8, but it redirected us to https://link.springer.com/article/10.1007/s12032-013-0517-8. The analysis below is for the second page.

Title[redir]:
Deregulation of protein phosphatase expression in acute myeloid leukemia | Medical Oncology
Description:
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We can't figure out the monetization strategy.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, protein, google, scholar, pubmed, cas, leukemia, myeloid, expression, acute, phosphatase, kazi, aml, phosphatases, cell, deregulation, kabir, flt, privacy, cookies, julhash, genes, blood, doiblood, kinases, gene, tyrosine, content, data, information, publish, research, search, february, human, access, genome, ronnstrand, leuk, cancer, author, analysis, log, journal, rönnstrand, disease, signaling, dusp, discover, leukaemia,

Topics {✒️}

jnk phosphatase dusp3/vhr month download article/chapter protein phosphatase deregulation protein phosphatase expression acute myeloid leukemia erk-dependent gene expression protein-tyrosine phosphatases protein tyrosine phosphatases chronic lymphocytic leukemia protein de-phosphorylation full article pdf eukaryotic protein kinases protein kinase complement frequent adult leukemia privacy choices/manage cookies myeloid cell line gene expression signature adapter protein grb10 mouse protein kinases highly malignant disease modulates receptor stability kabir & julhash phosphatase stress-activated kinases pediatric aml prognosis gene-expression profiling multiple biological processes international expert panel van den eijnden hooft van huijsduijnen pogosova-agadjanyan el biochim biophys acta breast cancer cells protein kinases article kabir mrna expression data aberrant cell proliferation conditions privacy policy kazi ju european economic area enrichment study suggests protein kinase skåne university hospital kabir nn accepting optional cookies inadequate treatment possibility genet mol biol identify prognostic subclasses protein phosphatases 11 protein phosphatases

Questions {❓}

Reversible phosphorylation in haematological malignancies: potential role for protein tyrosine phosphatases in treatment?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Deregulation of protein phosphatase expression in acute myeloid leukemia
         description:Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.
         datePublished:2013-02-26T00:00:00Z
         dateModified:2013-02-26T00:00:00Z
         pageStart:1
         pageEnd:6
         sameAs:https://doi.org/10.1007/s12032-013-0517-8
         keywords:
            Acute myeloid leukemia
            AML
            Protein phosphatase
            Protein tyrosine phosphatase
            Protein serine/threonine phosphatase
            Dual specificity protein phosphatase
            Oncology
            Hematology
            Pathology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig5_HTML.gif
         isPartOf:
            name:Medical Oncology
            issn:
               1559-131X
               1357-0560
            volumeNumber:30
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Nuzhat N. Kabir
               affiliation:
                     name:KN Biomedical Research Institute
                     address:
                        name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lars Rönnstrand
               affiliation:
                     name:Lund University
                     address:
                        name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Julhash U. Kazi
               affiliation:
                     name:KN Biomedical Research Institute
                     address:
                        name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
                        type:PostalAddress
                     type:Organization
                     name:Lund University
                     address:
                        name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Deregulation of protein phosphatase expression in acute myeloid leukemia
      description:Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.
      datePublished:2013-02-26T00:00:00Z
      dateModified:2013-02-26T00:00:00Z
      pageStart:1
      pageEnd:6
      sameAs:https://doi.org/10.1007/s12032-013-0517-8
      keywords:
         Acute myeloid leukemia
         AML
         Protein phosphatase
         Protein tyrosine phosphatase
         Protein serine/threonine phosphatase
         Dual specificity protein phosphatase
         Oncology
         Hematology
         Pathology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-013-0517-8/MediaObjects/12032_2013_517_Fig5_HTML.gif
      isPartOf:
         name:Medical Oncology
         issn:
            1559-131X
            1357-0560
         volumeNumber:30
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Nuzhat N. Kabir
            affiliation:
                  name:KN Biomedical Research Institute
                  address:
                     name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lars Rönnstrand
            affiliation:
                  name:Lund University
                  address:
                     name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julhash U. Kazi
            affiliation:
                  name:KN Biomedical Research Institute
                  address:
                     name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
                     type:PostalAddress
                  type:Organization
                  name:Lund University
                  address:
                     name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Medical Oncology
      issn:
         1559-131X
         1357-0560
      volumeNumber:30
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:KN Biomedical Research Institute
      address:
         name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
         type:PostalAddress
      name:Lund University
      address:
         name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
         type:PostalAddress
      name:KN Biomedical Research Institute
      address:
         name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
         type:PostalAddress
      name:Lund University
      address:
         name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Nuzhat N. Kabir
      affiliation:
            name:KN Biomedical Research Institute
            address:
               name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
               type:PostalAddress
            type:Organization
      name:Lars Rönnstrand
      affiliation:
            name:Lund University
            address:
               name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
               type:PostalAddress
            type:Organization
      name:Julhash U. Kazi
      affiliation:
            name:KN Biomedical Research Institute
            address:
               name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
               type:PostalAddress
            type:Organization
            name:Lund University
            address:
               name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
      name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
      name:Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
      name:Experimental Clinical Chemistry, Department of Laboratory Medicine, Wallenberg Laboratory, Skåne University Hospital, Lund University, Malmö, Sweden
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(133)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Crossref

3.98s.