
DOI . ORG {
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Title[redir]:
Optimal Treatment for Metastatic Bladder Cancer | Current Oncology Reports
Description:
Metastatic bladder cancer is a lethal disease. Cisplatin-based chemotherapy, including the combination regimens gemcitabine–cisplatin and methotrexate–vinblastine–doxorubicin–cisplatin, are the standard first-line therapies. Second-line therapies have modest activity and no significant improvement in patient outcomes. Agents targeting growth, survival, and proliferation pathways have been added to cytotoxic therapy with limited added benefit to date. Modulating host immune response to cancer-associated antigens appears promising, with multiple new therapeutic approaches being pursued. Next-generation sequencing of invasive urothelial carcinoma has provided insights into the biology of this disease and potential actionable targets. Alterations in the receptor tyrosine kinase/Ras pathway and the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway represent potential therapeutic targets in advanced disease, and novel agents are in development. Recent data from the Cancer Genome Atlas Research Network bladder cancer cohort and other efforts suggest that mutations in chromatin-regulatory genes are very common in invasive bladder tumors, and are more frequent than in other studied tumors. The discovery of new genomic alterations challenges drug development to change the course of this disease.
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Keywords {🔍}
cancer, google, scholar, pubmed, article, urothelial, oncol, cas, phase, bladder, clin, carcinoma, advanced, metastatic, trial, patients, study, cisplatin, gemcitabine, treatment, chemotherapy, results, suppl, central, transitional, cell, paclitaxel, randomized, oncology, rosenberg, growth, therapy, factor, doxorubicin, iii, tract, group, everolimus, research, alterations, receptor, mvac, methotrexate, vinblastine, clinical, urol, carboplatin, privacy, cookies, content,
Topics {✒️}
month download article/chapter muscle-invasive bladder cancer targeted therapies von der maase muscle-invasive urothelial carcinoma high-risk urothelial cancer high-dose-intensity methotrexate advanced/metastatic bladder cancer high-grade bladder cancer platinum-resistant urothelial cancer metastatic transitional-cell carcinoma phosphatidylinositol 3-kinase/protein kinase fixed dose-rate gemcitabine nanoparticle albumin-bound paclitaxel cancer genome atlas long-term survival results full article pdf metastatic bladder cancer urothelial bladder cancer receive cisplatin-based chemotherapy siefker-radtke ao phase iii trial invasive bladder tumors invasive urothelial carcinoma metastatic urothelial cancer urothelial bladder carcinoma transitional cell cancer advanced bladder cancer bladder cancer cells recurrent molecular alterations metastatic urothelial carcinoma anderson cancer center transitional cell carcinoma privacy choices/manage cookies advanced urothelial cancer potential actionable targets comprehensive molecular characterization phase iii study actionable genomic alterations phase ii trial advanced urothelial carcinoma combination regimens gemcitabine–cisplatin agents targeting growth therapeutic approaches predictive markers bladder tumor history phase ii study supportive care versus garcia-grossman ir sternberg cn
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headline:Optimal Treatment for Metastatic Bladder Cancer
description:Metastatic bladder cancer is a lethal disease. Cisplatin-based chemotherapy, including the combination regimens gemcitabine–cisplatin and methotrexate–vinblastine–doxorubicin–cisplatin, are the standard first-line therapies. Second-line therapies have modest activity and no significant improvement in patient outcomes. Agents targeting growth, survival, and proliferation pathways have been added to cytotoxic therapy with limited added benefit to date. Modulating host immune response to cancer-associated antigens appears promising, with multiple new therapeutic approaches being pursued. Next-generation sequencing of invasive urothelial carcinoma has provided insights into the biology of this disease and potential actionable targets. Alterations in the receptor tyrosine kinase/Ras pathway and the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway represent potential therapeutic targets in advanced disease, and novel agents are in development. Recent data from the Cancer Genome Atlas Research Network bladder cancer cohort and other efforts suggest that mutations in chromatin-regulatory genes are very common in invasive bladder tumors, and are more frequent than in other studied tumors. The discovery of new genomic alterations challenges drug development to change the course of this disease.
datePublished:2014-07-24T00:00:00Z
dateModified:2014-07-24T00:00:00Z
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Metastatic bladder cancer
Urothelial carcinoma
Immunotherapeutics
Molecular markers
Targeted therapies
Oncology
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headline:Optimal Treatment for Metastatic Bladder Cancer
description:Metastatic bladder cancer is a lethal disease. Cisplatin-based chemotherapy, including the combination regimens gemcitabine–cisplatin and methotrexate–vinblastine–doxorubicin–cisplatin, are the standard first-line therapies. Second-line therapies have modest activity and no significant improvement in patient outcomes. Agents targeting growth, survival, and proliferation pathways have been added to cytotoxic therapy with limited added benefit to date. Modulating host immune response to cancer-associated antigens appears promising, with multiple new therapeutic approaches being pursued. Next-generation sequencing of invasive urothelial carcinoma has provided insights into the biology of this disease and potential actionable targets. Alterations in the receptor tyrosine kinase/Ras pathway and the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway represent potential therapeutic targets in advanced disease, and novel agents are in development. Recent data from the Cancer Genome Atlas Research Network bladder cancer cohort and other efforts suggest that mutations in chromatin-regulatory genes are very common in invasive bladder tumors, and are more frequent than in other studied tumors. The discovery of new genomic alterations challenges drug development to change the course of this disease.
datePublished:2014-07-24T00:00:00Z
dateModified:2014-07-24T00:00:00Z
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Metastatic bladder cancer
Urothelial carcinoma
Immunotherapeutics
Molecular markers
Targeted therapies
Oncology
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Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
Emails and Hosting {✉️}
Mail Servers:
- mx.zoho.eu
- mx2.zoho.eu
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Name Servers:
- josh.ns.cloudflare.com
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CDN Services {📦}
- Crossref