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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s11523-022-00942-6, but it redirected us to https://link.springer.com/article/10.1007/s11523-022-00942-6. The analysis below is for the second page.

Title[redir]:
Optimizing Patient Pathways in Advanced Biliary Tract Cancers: Recent Advances and a French Perspective | Targeted Oncology
Description:
Biliary tract cancers (BTCs) are a heterogeneous group of tumors that are rare in Western countries and have a poor prognosis. Three subgroups are defined by their anatomical location (intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma and gallbladder carcinoma) and exhibit distinct clinical, molecular, and epidemiologic characteristics. Most patients are diagnosed at an advanced disease stage and are not eligible for curative-intent resection. In addition to first- and second-line chemotherapies (CisGem and FOLFOX, respectively), biologic therapies are now available that target specific genomic alterations identified in BTC. To date, targets include alterations in the genes for isocitrate dehydrogenase (IDH) 1, fibroblast growth factor receptor (FGFR) 2, v-raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2 or ERRB2), and neurotrophic tyrosine receptor kinase (NTRK), and for those leading to DNA mismatch repair deficiency. Therapies targeting these genomic alterations have demonstrated clinical benefit for patients with BTC. Despite these therapeutic advancements, genomic diagnostic modalities are not widely used in France, owing to a lack of clinician awareness, local availability of routine genomic testing, and difficulties in obtaining health insurance reimbursement. The addition of durvalumab, a monoclonal antibody targeting the immune checkpoint programmed cell death ligand-1, to CisGem in the first-line treatment of advanced BTC has shown an overall survival benefit in the TOPAZ-1 trial. Given the high mortality rates associated with BTC and the life-prolonging therapeutic options now available, it is hoped that the data presented here will support updates to the clinical management of BTC in France.

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

check SE Ranking
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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

patients, pubmed, article, google, scholar, cancer, cas, biliary, study, btc, phase, advanced, tract, cholangiocarcinoma, oncol, central, icca, trial, months, idh, treatment, fgfr, gemcitabine, clinical, median, chemotherapy, alterations, france, mutations, therapy, cisgem, cancers, therapies, genomic, group, cca, table, intrahepatic, disease, results, randomized, esmo, clin, french, tumor, response, firstline, httpsdoiorgs, targeted, molecular,

Topics {✒️}

fr/upload/docs/evamed/cnedimts-6082_therasphere_28_janvier_2020_ braf proto-oncogene b-raf patients receiving nal-iri-5-fu-lv nanoparticle albumin-bound–paclitaxel provided receiving nal-iri-5-fu-lv article  google scholar mitogen-activated protein kinase nal-iri-5-fu-lv arm nal-iri-5-fu-lv regimen agents targeting pd-1/pd-l1 advanced biliary-tract cancer formalin-fixed paraffin-embedded bispecific her2-targeted antibody anti-pd-1 monoclonal antibody ntrk fusion-positive cancers nal-iri-5-fu-lv adenocarcinoma/large duct type adenocarcinoma/small duct type atm ataxia-telangiectasia mutated jean-christophe sabourin ntrk gene fusion-positive trk fusion–positive cancers gov/drugsatfda_docs/label/2020/021492s016lbl gov/drugsatfda_docs/label/2021/211710s004lbl gov/drugsatfda_docs/label/2021/125514s096lbl gov/drugsatfda_docs/label/2021/211192_s008lbl gov/drugsatfda_docs/label/2019/212725s000lbl gov/drugsatfda_docs/label/2020/213736s000lbl gov/drugsatfda_docs/label/2021/214622s000lbl gov/drugsatfda_docs/label/2022/214801s000lbl trans-arterial embolisation therapies abou-alfa gk monoclonal antibody targeting université de paris population-based case-control study anti–pd-l1 antibody article download pdf curative-intent secondary resection antibody-drug conjugate consisting biliary tract cancers tyrosine kinase receptors paraffin-embedded tumor samples optimizing patient pathways dual anti-her2 regimen post-baseline tumor measurements mgmt methylguanine-dna methyltransferase broad-based tumor genotyping common bile duct durable anti-tumor activity actual long-term outcome

Questions {❓}

  • Is MGMT methylation a new therapeutic target for biliary tract cancer?
  • Oxaliplatin and ototoxicity: is it really safe for hearing?
  • Radiation therapy for liver tumors: ready for inclusion in guidelines?

Schema {🗺️}

WebPage:
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         headline:Optimizing Patient Pathways in Advanced Biliary Tract Cancers: Recent Advances and a French Perspective
         description:Biliary tract cancers (BTCs) are a heterogeneous group of tumors that are rare in Western countries and have a poor prognosis. Three subgroups are defined by their anatomical location (intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma and gallbladder carcinoma) and exhibit distinct clinical, molecular, and epidemiologic characteristics. Most patients are diagnosed at an advanced disease stage and are not eligible for curative-intent resection. In addition to first- and second-line chemotherapies (CisGem and FOLFOX, respectively), biologic therapies are now available that target specific genomic alterations identified in BTC. To date, targets include alterations in the genes for isocitrate dehydrogenase (IDH) 1, fibroblast growth factor receptor (FGFR) 2, v-raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2 or ERRB2), and neurotrophic tyrosine receptor kinase (NTRK), and for those leading to DNA mismatch repair deficiency. Therapies targeting these genomic alterations have demonstrated clinical benefit for patients with BTC. Despite these therapeutic advancements, genomic diagnostic modalities are not widely used in France, owing to a lack of clinician awareness, local availability of routine genomic testing, and difficulties in obtaining health insurance reimbursement. The addition of durvalumab, a monoclonal antibody targeting the immune checkpoint programmed cell death ligand-1, to CisGem in the first-line treatment of advanced BTC has shown an overall survival benefit in the TOPAZ-1 trial. Given the high mortality rates associated with BTC and the life-prolonging therapeutic options now available, it is hoped that the data presented here will support updates to the clinical management of BTC in France.
         datePublished:2023-02-06T00:00:00Z
         dateModified:2023-02-06T00:00:00Z
         pageStart:51
         pageEnd:76
         license:http://creativecommons.org/licenses/by-nc/4.0/
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                        name:Lille University Hospital, Lille, France
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                        name:CHU Cochin, Service de Gastroentérologie, Hôpital Cochin, Université de Paris, Paris, France
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                        name:Department of Medical Oncology, Institut Mutualiste Montsouris, Paris Cedex 14, France
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ScholarlyArticle:
      headline:Optimizing Patient Pathways in Advanced Biliary Tract Cancers: Recent Advances and a French Perspective
      description:Biliary tract cancers (BTCs) are a heterogeneous group of tumors that are rare in Western countries and have a poor prognosis. Three subgroups are defined by their anatomical location (intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma and gallbladder carcinoma) and exhibit distinct clinical, molecular, and epidemiologic characteristics. Most patients are diagnosed at an advanced disease stage and are not eligible for curative-intent resection. In addition to first- and second-line chemotherapies (CisGem and FOLFOX, respectively), biologic therapies are now available that target specific genomic alterations identified in BTC. To date, targets include alterations in the genes for isocitrate dehydrogenase (IDH) 1, fibroblast growth factor receptor (FGFR) 2, v-raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2 or ERRB2), and neurotrophic tyrosine receptor kinase (NTRK), and for those leading to DNA mismatch repair deficiency. Therapies targeting these genomic alterations have demonstrated clinical benefit for patients with BTC. Despite these therapeutic advancements, genomic diagnostic modalities are not widely used in France, owing to a lack of clinician awareness, local availability of routine genomic testing, and difficulties in obtaining health insurance reimbursement. The addition of durvalumab, a monoclonal antibody targeting the immune checkpoint programmed cell death ligand-1, to CisGem in the first-line treatment of advanced BTC has shown an overall survival benefit in the TOPAZ-1 trial. Given the high mortality rates associated with BTC and the life-prolonging therapeutic options now available, it is hoped that the data presented here will support updates to the clinical management of BTC in France.
      datePublished:2023-02-06T00:00:00Z
      dateModified:2023-02-06T00:00:00Z
      pageStart:51
      pageEnd:76
      license:http://creativecommons.org/licenses/by-nc/4.0/
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         Oncology
         Biomedicine
         general
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            type:ImageObject
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            affiliation:
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                  address:
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            affiliation:
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                  address:
                     name:CHU Montpellier, Montpellier, France
                     type:PostalAddress
                  type:Organization
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            name:Julien Edeline
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                  address:
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                     type:PostalAddress
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            type:Person
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                     type:PostalAddress
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                  address:
                     name:CHU Cochin, Service de Gastroentérologie, Hôpital Cochin, Université de Paris, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Malka
            url:http://orcid.org/0000-0002-7664-0130
            affiliation:
                  name:Institut Mutualiste Montsouris
                  address:
                     name:Department of Medical Oncology, Institut Mutualiste Montsouris, Paris Cedex 14, France
                     type:PostalAddress
                  type:Organization
                  name:Université Paris-Saclay
                  address:
                     name:Université Paris-Saclay, Villejuif, France
                     type:PostalAddress
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      name:Institut Mutualiste Montsouris
      address:
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            name:Jean Mermoz Hospital
            address:
               name:Jean Mermoz Hospital, Lyon, France
               type:PostalAddress
            type:Organization
      name:Eric Assenat
      affiliation:
            name:CHU Montpellier
            address:
               name:CHU Montpellier, Montpellier, France
               type:PostalAddress
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      name:Julien Edeline
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      affiliation:
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               type:PostalAddress
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      affiliation:
            name:Saint Joseph Hospital
            address:
               name:Saint Joseph Hospital, Marseille, France
               type:PostalAddress
            type:Organization
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            name:Rouen University Hospital, Normandie University
            address:
               name:Department of Pathology, Rouen University Hospital, Normandie University, Rouen, France
               type:PostalAddress
            type:Organization
      name:Anthony Turpin
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      affiliation:
            name:Lille University Hospital
            address:
               name:Lille University Hospital, Lille, France
               type:PostalAddress
            type:Organization
      name:Romain Coriat
      affiliation:
            name:CHU Cochin, Service de Gastroentérologie, Hôpital Cochin, Université de Paris
            address:
               name:CHU Cochin, Service de Gastroentérologie, Hôpital Cochin, Université de Paris, Paris, France
               type:PostalAddress
            type:Organization
      name:David Malka
      url:http://orcid.org/0000-0002-7664-0130
      affiliation:
            name:Institut Mutualiste Montsouris
            address:
               name:Department of Medical Oncology, Institut Mutualiste Montsouris, Paris Cedex 14, France
               type:PostalAddress
            type:Organization
            name:Université Paris-Saclay
            address:
               name:Université Paris-Saclay, Villejuif, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institut Curie, St Cloud, France
      name:Jean Mermoz Hospital, Lyon, France
      name:CHU Montpellier, Montpellier, France
      name:Centre Eugène Marquis, Rennes, France
      name:Saint Joseph Hospital, Marseille, France
      name:Department of Pathology, Rouen University Hospital, Normandie University, Rouen, France
      name:Lille University Hospital, Lille, France
      name:CHU Cochin, Service de Gastroentérologie, Hôpital Cochin, Université de Paris, Paris, France
      name:Department of Medical Oncology, Institut Mutualiste Montsouris, Paris Cedex 14, France
      name:Université Paris-Saclay, Villejuif, France

External Links {🔗}(750)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

6s.