
DOI . ORG {
}
Title[redir]:
The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation | Journal of Biomedical Science
Description:
Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
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google, scholar, pubmed, cas, article, cell, kinase, cancer, dapkinase, protein, biol, deathassociated, kimchi, death, apoptosis, chen, res, hypermethylation, promoter, dap, gene, expression, tumor, regulation, role, cohen, methylation, science, suppressor, kuo, integrin, dapk, genes, privacy, cookies, function, journal, wang, signaling, activity, carcinoma, oncogene, clin, anoikis, content, publish, search, download, feinstein, embo,
Topics {โ๏ธ}
won-jing wangย &ย jean-cheng kuo p19arf/p53-mediated apoptotic checkpoint involve myosin-ii phosphorylation brain hypoxic-ischemic injury tgf-beta induces apoptosis adhesion-mediated signaling dapkโerk interaction promote dap-kinase induces apoptosis dap-kinase-mediated morphological dap-kinase cpg island serine/threonine kinase dap kinase links cell death-inducing functions dap-kinase protein function privacy choices/manage cookies tumor suppressor gene related subjects bidirectional signals transduced suppress oncogenic transformation fas-induced apoptosis trail-induced apoptosis ceramide- induced apoptosis ceramide-induced apoptosis ruey-hwa chen b-cell malignancies smad-mediated expression programmed cell death kinase cpg island dap kinase activates integrin beta tails final common step protein-kinase gene tyrosine kinase-dependent key regulatory element cpg island methylation bak-mcl1 complex national taiwan university protein kinase mrnas ca2+/calmodulin-dependent gene promoter methylation dap-kinase elicits dap kinase family modulating integrin inside european economic area pro-apoptotic proteins invasive pituitary tumours cultured hippocampal neurons atg7-beclin 1 program squamous cell cancer pro-apoptotic function
Questions {โ}
- , To die or not to die: how does p53 decide?
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mainEntity:
headline:The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation
description:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
datePublished:2006-02-03T00:00:00Z
dateModified:2006-02-03T00:00:00Z
pageStart:193
pageEnd:199
sameAs:https://doi.org/10.1007/s11373-005-9063-5
keywords:
anoikis, cell death, cytoskeleton, DAP-kinase, tumor suppressor
Biomedicine
general
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1423-0127
1021-7770
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ScholarlyArticle:
headline:The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation
description:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
datePublished:2006-02-03T00:00:00Z
dateModified:2006-02-03T00:00:00Z
pageStart:193
pageEnd:199
sameAs:https://doi.org/10.1007/s11373-005-9063-5
keywords:
anoikis, cell death, cytoskeleton, DAP-kinase, tumor suppressor
Biomedicine
general
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1423-0127
1021-7770
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