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We began analyzing https://link.springer.com/article/10.1007/s11033-004-6941-2, but it redirected us to https://link.springer.com/article/10.1007/s11033-004-6941-2. The analysis below is for the second page.

Title[redir]:
Modulation of Lactate Dehydrogenase Isozymes by Modified Base Queuine | Molecular Biology Reports
Description:
The modified base queuine is a nutrient factor for lower and higher eukaryotes except yeast. It is synthesized in eubacteria and inserted into the wobble position of specific tRNAs (tRNAGUN) in exchange of guanine at position 34. The tRNAs of Q family are completely modified in terminally differentiated somatic cells. However, mainly free queuine is present in embryonic and fast proliferating cells, tRNA remains Q deficient. Lactate dehydrogenase (LDH) A mRNA and LDH A protein is known to increase when cells are grown in hypoxic conditions. In the present study, the level of LDH isozymes is analyzed in different tissues of normal and cancerous (DLA) mice and the effect of queuine treatment on LDH isozyme is observed. LDH A isozyme is shown to increase in serum and liver of DLA mice. The level and activity of LDH A decreases on queuine treatment. In skeletal muscle and heart, LDH A isozyme decreases while LDH B increases in DLA mice. Queuine administration leads to change back towards normal. In case of brain, LDH A increases but LDH B decreases in DLA mice. Queuine treatment leads to decrease in A4 anaerobic isozymes of LDH. The results suggest that queuine suppresses anaerobic glycolytic pathway, which leads to tumor suppression of DLA mice.

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google, scholar, article, ldh, queuine, pubmed, kersten, lactate, dehydrogenase, access, chem, privacy, cookies, content, molecular, dla, mice, cancer, res, publish, research, search, biology, isozymes, modified, vinayak, nishimura, langgut, data, information, log, journal, base, pathak, manjula, cells, study, treatment, isozyme, decreases, leads, open, discover, biochemistry, biol, reisser, biochem, okada, download, author,

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month download article/chapter nucleic acid research modified base queuine privacy choices/manage cookies pathak & manjula vinayak full article pdf tumor suppression molecular modeling lactate dehydrogenase isoforms lactate dehydrogenase isozymes a4 anaerobic isozymes queuine administration leads european economic area scope submit manuscript related subjects ochieng rw trewyn weber pa maubach inomata ms sakati banaras hindu university article pathak fast proliferating cells queuine treatment leads conditions privacy policy accepting optional cookies check access instant access main content log trna remains journal finder publish lactate dehydrogenase manjula vinayak article log author correspondence usage analysis article cite queuine treatment free queuine privacy policy personal data completely modified books a cancer res optional cookies manage preferences modulation data protection essential cookies cookies skip subscription content similar content

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