
DOI . ORG {
}
Title[redir]:
KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells | Molecular and Cellular Biochemistry
Description:
Krüppel-like factor 5 (KLF5) plays an important role in cellular proliferation and differentiation. In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while human heart LIM protein (hhLIM) decreased neointimal formation following vascular injury. Interestingly, neointimal formation was significantly increased in the animals where both hhLIM and KLF5 were introduced, suggesting that KLF5 can reverse hhLIM function in cell proliferation on the coexpression with hhLIM. These results were also confirmed the cellular level. Further mechanistic studies suggested that PDGF-BB promoted the interaction between hhLIM and KLF5 through stimulating hhLIM binding to TGF-β control element (TCE) on the cyclin E promoter in a KLF5-dependent manner. Failure of KLF5 binding to the TCE, on the knockdown of KLF5 by transfecting siRNA, not only prevented the recruitment of hhLIM to the cyclin E promoter but also affected activation of the cyclin E promoter by KLF5. These data suggest that KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.
Matching Content Categories {📚}
- Education
- Science
- Health & Fitness
Content Management System {📝}
What CMS is doi.org built with?
Custom-built
No common CMS systems were detected on Doi.org, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of doi.org audience?
🏙️ Massive Traffic: 50M - 100M visitors per month
Based on our best estimate, this website will receive around 80,486,609 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Doi.org Make Money? {💸}
We don’t know how the website earns money.
Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.
Keywords {🔍}
article, pubmed, cas, google, scholar, klf, vascular, smooth, muscle, cells, hhlim, zheng, factor, cell, proliferation, growth, han, biol, access, chem, physiol, privacy, cookies, content, miao, liu, neointimal, formation, protein, interaction, cyclin, promoter, expression, transcription, zhang, data, publish, search, cellular, biochemistry, heart, pdgfbb, binding, inhibits, dong, function, information, log, journal, research,
Topics {✒️}
tgf-β control element nf-kappab regulating cell cycle month download article/chapter protein kinase c-delta p15 transcription factors erk-dependent rna turn yan liu & bin zheng pro-proliferative factor klf5 pdgf-bb promoted pdgf-bb represses cell-cell adhesion cell growth autocrine growth mechanisms full article pdf related subjects signaling-mediated modification privacy choices/manage cookies tgf-beta adenovirus-mediated overexpression klf1 impair expression matrix metalloproteinase expression embryonic stem cells cell proliferation article shi klf5-dependent manner c-jun leading actin cytoskeleton remodeling hebei medical university decreased neointimal formation check access instant access european economic area oncogenic regulator set dna-binding domain cis-dna elements drosophila double-parked zhongshan east road article molecular stimulating hhlim binding conditions privacy policy sm22{alpha} promoter reverse hhlim function sui-bing miao bin zheng accepting optional cookies jin-kun wen cellular biochemistry aims mechanistic studies suggested atra activates
Schema {🗺️}
WebPage:
mainEntity:
headline:KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells
description:Krüppel-like factor 5 (KLF5) plays an important role in cellular proliferation and differentiation. In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while human heart LIM protein (hhLIM) decreased neointimal formation following vascular injury. Interestingly, neointimal formation was significantly increased in the animals where both hhLIM and KLF5 were introduced, suggesting that KLF5 can reverse hhLIM function in cell proliferation on the coexpression with hhLIM. These results were also confirmed the cellular level. Further mechanistic studies suggested that PDGF-BB promoted the interaction between hhLIM and KLF5 through stimulating hhLIM binding to TGF-β control element (TCE) on the cyclin E promoter in a KLF5-dependent manner. Failure of KLF5 binding to the TCE, on the knockdown of KLF5 by transfecting siRNA, not only prevented the recruitment of hhLIM to the cyclin E promoter but also affected activation of the cyclin E promoter by KLF5. These data suggest that KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.
datePublished:2012-05-15T00:00:00Z
dateModified:2012-05-15T00:00:00Z
pageStart:185
pageEnd:194
sameAs:https://doi.org/10.1007/s11010-012-1332-9
keywords:
KLF5
PDGF-BB
hhLIM
VSMC
TGF-β control element
Biochemistry
general
Cardiology
Cancer Research
Medical Biochemistry
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig5_HTML.gif
isPartOf:
name:Molecular and Cellular Biochemistry
issn:
1573-4919
0300-8177
volumeNumber:367
type:
Periodical
PublicationVolume
publisher:
name:Springer US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Hui-jing Shi
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Jin-kun Wen
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Sui-bing Miao
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Yan Liu
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Bin Zheng
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells
description:Krüppel-like factor 5 (KLF5) plays an important role in cellular proliferation and differentiation. In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while human heart LIM protein (hhLIM) decreased neointimal formation following vascular injury. Interestingly, neointimal formation was significantly increased in the animals where both hhLIM and KLF5 were introduced, suggesting that KLF5 can reverse hhLIM function in cell proliferation on the coexpression with hhLIM. These results were also confirmed the cellular level. Further mechanistic studies suggested that PDGF-BB promoted the interaction between hhLIM and KLF5 through stimulating hhLIM binding to TGF-β control element (TCE) on the cyclin E promoter in a KLF5-dependent manner. Failure of KLF5 binding to the TCE, on the knockdown of KLF5 by transfecting siRNA, not only prevented the recruitment of hhLIM to the cyclin E promoter but also affected activation of the cyclin E promoter by KLF5. These data suggest that KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.
datePublished:2012-05-15T00:00:00Z
dateModified:2012-05-15T00:00:00Z
pageStart:185
pageEnd:194
sameAs:https://doi.org/10.1007/s11010-012-1332-9
keywords:
KLF5
PDGF-BB
hhLIM
VSMC
TGF-β control element
Biochemistry
general
Cardiology
Cancer Research
Medical Biochemistry
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig5_HTML.gif
isPartOf:
name:Molecular and Cellular Biochemistry
issn:
1573-4919
0300-8177
volumeNumber:367
type:
Periodical
PublicationVolume
publisher:
name:Springer US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Hui-jing Shi
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Jin-kun Wen
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Sui-bing Miao
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Yan Liu
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
type:Person
name:Bin Zheng
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Molecular and Cellular Biochemistry
issn:
1573-4919
0300-8177
volumeNumber:367
Organization:
name:Springer US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Hui-jing Shi
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
name:Jin-kun Wen
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
name:Sui-bing Miao
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
name:Yan Liu
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
name:Bin Zheng
affiliation:
name:Hebei Medical University
address:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(155)
- https://link.springer.com/privacystatement's revenue stream
- How much income does https://link.springer.com/article/10.1007/s11010-012-1332-9/#main have?
- Income figures for https://link.springer.com
- https://idp.springer.com/auth/personal/springernature?redirect_uri=https://link.springer.com/article/10.1007/s11010-012-1332-9 income
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/#eds-c-header-nav pull in?
- How much does https://link.springer.com/journals/ pull in?
- What's the profit of https://www.springernature.com/gp/authors?
- What are the total earnings of https://link.springernature.com/home/?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/#eds-c-header-popup-search pull in monthly?
- What's the monthly income of https://order.springer.com/public/cart?
- How much money does https://link.springer.com/article/10.1007/s11010-012-1332-9/ generate?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/journal/11010 gross monthly?
- What's https://link.springer.com/article/10.1007/s11010-012-1332-9/#citeas's gross income?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/journal/11010/aims-and-scope bring in each month?
- How much does https://submission.nature.com/new-submission/11010/3 bring in each month?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/#auth-Hui_jing-Shi-Aff1 gross monthly?
- How profitable is https://link.springer.com/article/10.1007/s11010-012-1332-9/#Aff1?
- What's the total monthly financial gain of https://link.springer.com/article/10.1007/s11010-012-1332-9/#auth-Jin_kun-Wen-Aff1?
- What's the profit of https://link.springer.com/article/10.1007/s11010-012-1332-9/#auth-Sui_bing-Miao-Aff1?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/#auth-Yan-Liu-Aff1 pull in?
- What's the profit of https://link.springer.com/article/10.1007/s11010-012-1332-9/#auth-Bin-Zheng-Aff1?
- How much money does https://link.springer.com/article/10.1007/s11010-012-1332-9/article/10.1007/s11010-012-1332-9/metrics make?
- Explore the financials of https://wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs11010-012-1332-9
- Find out how much https://link.springer.com/product/springer-plus earns monthly
- What's the financial intake of https://www.springernature.com/gp/librarians/licensing/agc/journals?
- See how much https://link.springer.com/10.1038/s41467-024-50579-4?fromPaywallRec=true makes per month
- How much income does https://link.springer.com/10.1038/s41467-024-51747-2?fromPaywallRec=true have?
- Revenue of https://link.springer.com/10.1007/s12012-024-09911-z?fromPaywallRec=true
- https://link.springer.com/article/10.1007/s11010-012-1332-9/subjects/cell-cycle-proteins's total income per month
- What's the income generated by https://link.springer.com/article/10.1007/s11010-012-1332-9/subjects/haematopoietic-cell-growth-factor each month?
- How much money does https://link.springer.com/article/10.1007/s11010-012-1332-9/subjects/hepatocyte-growth-factor make?
- Profit of https://link.springer.com/article/10.1007/s11010-012-1332-9/subjects/nf-kappab
- https://link.springer.com/article/10.1007/s11010-012-1332-9/subjects/transcription-factors's total income per month
- Get to know what's the income of https://link.springer.com/article/10.1007/s11010-012-1332-9/subjects/ubiquitin-ligases
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21282300 make?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BC3MXosVOmtbc%3D gross monthly?
- Profit of http://scholar.google.com/scholar_lookup?&title=Vascularizing%20the%20heart&journal=Cardiovasc%20Res&doi=10.1093%2Fcvr%2Fcvr035&volume=91&pages=260-268&publication_year=2011&author=Riley%2CPR&author=Smart%2CN
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16317118
- Profit of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD2MXhtlalsL3J
- How much does http://scholar.google.com/scholar_lookup?&title=Resveratrol%20inhibits%20TNF-alpha-induced%20proliferation%20and%20matrix%20metalloproteinase%20expression%20in%20human%20vascular%20smooth%20muscle%20cells&journal=J%20Nutr&volume=135&pages=2767-2773&publication_year=2005&author=Lee%2CB&author=Moon%2CSK generate monthly?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19531492 generate?
- What is the earnings of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXpvFKitLw%3D?
- How much income is http://scholar.google.com/scholar_lookup?&title=Kruppel-like%20factor%204%20inhibits%20proliferation%20by%20platelet-derived%20growth%20factor%20receptor%20beta-mediated%2C%20not%20by%20retinoic%20acid%20receptor%20alpha-mediated%2C%20phosphatidylinositol%203-kinase%20and%20ERK%20signaling%20in%20vascular%20smooth%20muscle%20cells&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M109.026989&volume=284&issue=34&pages=22773-22785&publication_year=2009&author=Zheng%2CB&author=Han%2CM&author=Bernier%2CM&author=Zhang%2CXH&author=Meng%2CF&author=Miao%2CSB&author=He%2CM&author=Zhao%2CXM&author=Wen%2CJK earning monthly?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15894805 make?
- What's the total monthly financial gain of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD2MXlslyltbY%3D?
- Earnings of http://scholar.google.com/scholar_lookup?&title=PDGF-BB%20regulates%20p27%20expression%20through%20ERK-dependent%20RNA%20turn-over%20in%20vascular%20smooth%20muscle%20cells&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M502320200&volume=280&pages=25470-25477&publication_year=2005&author=Sakakibara%2CK&author=Kubota%2CK&author=Worku%2CB&author=Ryer%2CEJ&author=Miller%2CJP&author=Koff%2CA&author=Kent%2CKC&author=Liu%2CB
- What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19525370?
- https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXhtVahtrvN's total income per month
- http://scholar.google.com/scholar_lookup?&title=TGF-beta%20through%20Smad3%20signaling%20stimulates%20vascular%20smooth%20muscle%20cell%20proliferation%20and%20neointimal%20formation&journal=Am%20J%20Physiol%20Heart%20Circ%20Physiol&doi=10.1152%2Fajpheart.91478.2007&volume=297&pages=H540-H549&publication_year=2009&author=Tsai%2CS&author=Hollenbeck%2CST&author=Ryer%2CEJ&author=Edlin%2CR&author=Yamanouchi%2CD&author=Kundi%2CR&author=Wang%2CC&author=Liu%2CB&author=Kent%2CKC's total income per month
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14612398 generate monthly?
- https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD3sXptFaisLs%3D's total income per month
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Positive%20and%20negative%20regulation%20of%20the%20cardiovascular%20transcription%20factor%20KLF5%20by%20p300%20and%20the%20oncogenic%20regulator%20SET%20through%20interaction%20and%20acetylation%20on%20the%20DNA-binding%20domain&journal=Mol%20Cell%20Biol&doi=10.1128%2FMCB.23.23.8528-8541.2003&volume=23&pages=8528-8541&publication_year=2003&author=Miyamoto%2CS&author=Suzuki%2CT&author=Muto%2CS&author=Aizawa%2CK&author=Kimura%2CA&author=Mizuno%2CY&author=Nagino%2CT&author=Imai%2CY&author=Adachi%2CN&author=Horikoshi%2CM&author=Nagai%2CR?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19628677's total income per month
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXhtlyrt77O net monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Angiotensin%20II%20stimulates%20KLF5%20phosphorylation%20and%20its%20interaction%20with%20c-Jun%20leading%20to%20suppression%20of%20p21%20expression%20in%20vascular%20smooth%20muscle%20cells&journal=J%20Biochem&doi=10.1093%2Fjb%2Fmvp115&volume=146&pages=683-691&publication_year=2009&author=He%2CM&author=Han%2CM&author=Zheng%2CB&author=Shu%2CYN&author=Wen%2CJK make?
- What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19292987?
- https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXksVCktrc%3D's financial summary
- http://scholar.google.com/scholar_lookup?&title=Synthetic%20retinoid%20Am80%20inhibits%20interaction%20of%20KLF5%20with%20RAR%20alpha%20through%20inducing%20KLF5%20dephosphorylation%20mediated%20by%20the%20PI3%C2%A0K%2FAkt%20signaling%20in%20vascular%20smooth%20muscle%20cells&journal=FEBS%20Lett&doi=10.1016%2Fj.febslet.2009.03.016&volume=583&pages=1231-1236&publication_year=2009&author=Zhang%2CXH&author=Zheng%2CB&author=Han%2CM&author=Miao%2CSB&author=Wen%2CJK income
- What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19542014?
- How much revenue does https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXot1ektrc%3D generate?
- How much does http://scholar.google.com/scholar_lookup?&title=MicroRNA-145%2C%20a%20novel%20smooth%20muscle%20cell%20phenotypic%20marker%20and%20modulator%2C%20controls%20vascular%20neointimal%20lesion%20formation&journal=Circ%20Res&doi=10.1161%2FCIRCRESAHA.109.197517&volume=105&pages=158-166&publication_year=2009&author=Cheng%2CY&author=Liu%2CX&author=Yang%2CJ&author=Lin%2CY&author=Xu%2CDZ&author=Lu%2CQ&author=Deitch%2CEA&author=Huo%2CY&author=Delphin%2CES&author=Zhang%2CC bring in each month?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16956962 generate monthly?
- How profitable is https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD2sXisFCrtLk%3D?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Multiple%20repressor%20pathways%20contribute%20to%20phenotypic%20switching%20of%20vascular%20smooth%20muscle%20cells&journal=Am%20J%20Physiol%20Cell%20Physiol&doi=10.1152%2Fajpcell.00394.2006&volume=292&pages=C59-C69&publication_year=2007&author=Kawai-Kowase%2CK&author=Owens%2CGK?
- Check the income stats for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16487072
- See how much https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD28XislSlurs%3D makes per month
- Find out how much http://scholar.google.com/scholar_lookup?&title=hhLIM%20is%20involved%20in%20cardiomyogenesis%20of%20embryonic%20stem%20cells&journal=Biochemistry&volume=71&issue=Suppl%201&pages=S71-S76&publication_year=2006&author=Zheng%2CB&author=Wen%2CJK&author=Han%2CM earns monthly
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18387947's revenue stream
- Check the income stats for https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1cXmtlynt7s%3D
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Transforming%20growth%20factor%20beta%20up-regulates%20cysteine-rich%20protein%202%20in%20vascular%20smooth%20muscle%20cells%20via%20activating%20transcription%20factor%202&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M801621200&volume=283&pages=15003-15014&publication_year=2008&author=Lin%2CDW&author=Chang%2CIC&author=Tseng%2CA&author=Wu%2CML&author=Chen%2CCH&author=Patenaude%2CCA&author=Layne%2CMD&author=Yet%2CSF
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17927564's revenue stream
- What's the monthly income of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1cXls1KhtA%3D%3D?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Human%20heart%20LIM%20protein%20activates%20atrial-natriuretic-factor%20gene%20expression%20by%20interacting%20with%20the%20cardiac-restricted%20transcription%20factor%20Nkx2.5&journal=Biochem%20J&doi=10.1042%2FBJ20070977&volume=409&pages=683-690&publication_year=2008&author=Zheng%2CB&author=Han%2CM&author=Wen%2CJK&author=Zhang%2CR have monthly?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18083124 produce monthly?
- Find out how much https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1cXpsF2nsA%3D%3D earns monthly
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Roscovitine%20inhibits%20ERK1%2F2%20activation%20induced%20by%20angiotensin%20II%20in%20vascular%20smooth%20muscle%20cells&journal=FEBS%20Lett&doi=10.1016%2Fj.febslet.2007.12.011&volume=582&pages=243-248&publication_year=2008&author=Li%2CAY&author=Han%2CM&author=Zheng%2CB&author=Wen%2CJK is on a monthly basis
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18331358's financial summary
- How much money does https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1cXksFehu78%3D make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=hhLIM%20is%20a%20novel%20F-actin%20binding%20protein%20involved%20in%20actin%20cytoskeleton%20remodeling&journal=FEBS%20J&doi=10.1111%2Fj.1742-4658.2008.06315.x&volume=275&pages=1568-1578&publication_year=2008&author=Zheng%2CB&author=Wen%2CJK&author=Han%2CM bring in?
- What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19056724?
- How much revenue does https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXisVSksb4%3D produce monthly?
- What's http://scholar.google.com/scholar_lookup?&title=Pro-proliferative%20factor%20KLF5%20becomes%20anti-proliferative%20in%20epithelial%20homeostasis%20upon%20signaling-mediated%20modification&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M806270200&volume=284&pages=6071-6078&publication_year=2009&author=Guo%2CP&author=Dong%2CXY&author=Zhang%2CX&author=Zhao%2CKW&author=Sun%2CX&author=Li%2CQ&author=Dong%2CJT's gross income?
- Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19419955's earnings
- Financial intake of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXnslegtL4%3D
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Acetylation%20of%20KLF5%20alters%20the%20assembly%20of%20p15%20transcription%20factors%20in%20transforming%20growth%20factor-beta-mediated%20induction%20in%20epithelial%20cells&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M109.007096&volume=284&pages=18184-18193&publication_year=2009&author=Guo%2CP&author=Zhao%2CKW&author=Dong%2CXY&author=Sun%2CX&author=Dong%2CJT have monthly?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15345514's total income per month
- What's the monthly income of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD2cXptV2isrk%3D?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Altered%20PDGF-BB-induced%20p38%20MAP%20kinase%20activation%20in%20diabetic%20vascular%20smooth%20muscle%20cells%3A%20roles%20of%20protein%20kinase%20C-delta&journal=Arterioscler%20Thromb%20Vasc%20Biol&doi=10.1161%2F01.ATV.0000144009.35400.65&volume=24&pages=2095-2101&publication_year=2004&author=Yamaguchi%2CH&author=Igarashi%2CM&author=Hirata%2CA&author=Sugae%2CN&author=Tsuchiya%2CH&author=Jimbu%2CY&author=Tominaga%2CM&author=Kato%2CT?
- Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21252119
- Profit of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BC3MXmsVOltLg%3D
- How profitable is http://scholar.google.com/scholar_lookup?&title=ATRA%20activates%20and%20PDGF-BB%20represses%20the%20SM22%7Balpha%7D%20promoter%20through%20KLF4%20binding%20to%2C%20or%20dissociating%20from%2C%20its%20cis-DNA%20elements&journal=Cardiovasc%20Res&doi=10.1093%2Fcvr%2Fcvr017&volume=90&pages=464-474&publication_year=2011&author=Yu%2CK&author=Zheng%2CB&author=Han%2CM&author=Wen%2CJK?
- What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11427690?
- How much profit is https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD3MXlt1Oiu7c%3D making per month?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Vascular%20smooth%20muscle%20growth%3A%20autocrine%20growth%20mechanisms&journal=Physiol%20Rev&volume=81&pages=999-1030&publication_year=2001&author=Berk%2CBC
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20458445?
- What's the income generated by https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BC3cXlsFGrsLk%3D each month?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Leptin-induced%20vascular%20smooth%20muscle%20cell%20proliferation%20via%20regulating%20cell%20cycle%2C%20activating%20ERK1%2F2%20and%20NF-kappaB&journal=Acta%20Biochim%20Biophys%20Sin&doi=10.1093%2Fabbs%2Fgmq025&volume=42&pages=325-331&publication_year=2010&author=Huang%2CF&author=Xiong%2CX&author=Wang%2CH&author=You%2CS&author=Zeng%2CH earns monthly
- Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19903826
- How much profit does https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BC3cXhsFeitb4%3D make?
- How much profit does http://scholar.google.com/scholar_lookup?&title=A%20novel%20roscovitine%20derivative%20potently%20induces%20G1-phase%20arrest%20in%20platelet-derived%20growth%20factor-BB-activated%20vascular%20smooth%20muscle%20cells&journal=Mol%20Pharmacol&doi=10.1124%2Fmol.109.060327&volume=77&pages=255-261&publication_year=2010&author=Sroka%2CIM&author=Heiss%2CEH&author=Havlicek%2CL&author=Totzke%2CF&author=Aristei%2CY&author=Pechan%2CP&author=Kubbutat%2CMH&author=Strnad%2CM&author=Dirsch%2CVM generate?
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15342466
- Monthly income for https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD2cXptVOlu7c%3D
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Drosophila%20double-parked%20is%20sufficient%20to%20induce%20re-replication%20during%20development%20and%20is%20regulated%20by%20cyclin%20E%2FCDK2&journal=Development&doi=10.1242%2Fdev.01348&volume=131&pages=4807-4818&publication_year=2004&author=Thomer%2CM&author=May%2CNR&author=Aggarwal%2CBD&author=Kwok%2CG&author=Calvi%2CBR
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20959618's revenue stream
- What's the total monthly financial gain of https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BC3cXhsFSqtbjM?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Mammalian%20Kruppel-like%20factors%20in%20health%20and%20diseases&journal=Physiol%20Rev&doi=10.1152%2Fphysrev.00058.2009&volume=90&pages=1337-1381&publication_year=2010&author=McConnell%2CBB&author=Yang%2CVW earns monthly
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19189969 make?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/articles/cas-redirect/1:CAS:528:DC%2BD1MXjs1ymsbc%3D generate monthly?
- See how much http://scholar.google.com/scholar_lookup?&title=Kruppel-like%20factor%205%20shows%20proliferation-specific%20roles%20in%20vascular%20remodeling%2C%20direct%20stimulation%20of%20cell%20growth%2C%20and%20inhibition%20of%20apoptosis&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M806230200&volume=284&pages=9549-9557&publication_year=2009&author=Suzuki%2CT&author=Sawaki%2CD&author=Aizawa%2CK&author=Munemasa%2CY&author=Matsumura%2CT&author=Ishida%2CJ&author=Nagai%2CR makes per month
- How much income does https://citation-needed.springer.com/v2/references/10.1007/s11010-012-1332-9?format=refman&flavour=references have?
- Financial intake of https://link.springer.com/article/10.1007/s11010-012-1332-9/search?sortBy=newestFirst&dc.creator=Hui-jing%20Shi
- What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hui-jing%20Shi?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hui-jing%20Shi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
- How much money does https://link.springer.com/article/10.1007/s11010-012-1332-9/search?sortBy=newestFirst&dc.creator=Jin-kun%20Wen generate?
- What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jin-kun%20Wen's gross income?
- What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jin-kun%20Wen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Discover the revenue of https://link.springer.com/article/10.1007/s11010-012-1332-9/search?sortBy=newestFirst&dc.creator=Sui-bing%20Miao
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sui-bing%20Miao is on a monthly basis
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sui-bing%20Miao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
- How much income is https://link.springer.com/article/10.1007/s11010-012-1332-9/search?sortBy=newestFirst&dc.creator=Yan%20Liu earning monthly?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yan%20Liu's total income per month
- Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yan%20Liu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/search?sortBy=newestFirst&dc.creator=Bin%20Zheng pull in?
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bin%20Zheng
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bin%20Zheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- How much profit is https://link.springer.com/article/10.1007/s11010-012-1332-9/mailto:[email protected] making per month?
- What are the total earnings of https://s100.copyright.com/AppDispatchServlet?title=KLF5%20and%20hhLIM%20cooperatively%20promote%20proliferation%20of%20vascular%20smooth%20muscle%20cells&author=Hui-jing%20Shi%20et%20al&contentID=10.1007%2Fs11010-012-1332-9©right=Springer%20Science%2BBusiness%20Media%2C%20LLC.&publication=0300-8177&publicationDate=2012-05-15&publisherName=SpringerNature&orderBeanReset=true?
- How much profit does https://citation-needed.springer.com/v2/references/10.1007/s11010-012-1332-9?format=refman&flavour=citation make?
- What's the financial gain of https://link.springer.com/article/10.1007/s11010-012-1332-9/search?query=KLF5&facet-discipline="Life%20Sciences"?
- What are the earnings of https://link.springer.com/article/10.1007/s11010-012-1332-9/search?query=PDGF-BB&facet-discipline="Life%20Sciences"?
- How much does https://link.springer.com/article/10.1007/s11010-012-1332-9/search?query=hhLIM&facet-discipline="Life%20Sciences" pull in monthly?
- Discover the revenue of https://link.springer.com/article/10.1007/s11010-012-1332-9/search?query=VSMC&facet-discipline="Life%20Sciences"
- What's https://link.springer.com/article/10.1007/s11010-012-1332-9/search?query=TGF-%CE%B2%20control%20element&facet-discipline="Life%20Sciences"'s gross income?
- How much does https://link.springer.com/journals/a/1 pull in?
- Check the income stats for https://link.springer.com/books/a/1
- How much cash flow does https://link.springer.com/journals have monthly?
- https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral's total income per month
- Get to know https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research's earnings
- What's the financial outcome of https://www.springernature.com/gp/products?
- See how much https://www.springernature.com/gp/librarians makes per month
- How much does https://www.springernature.com/gp/societies gross monthly?
- What's the profit of https://www.springernature.com/gp/partners?
- Learn how profitable https://www.springer.com/ is on a monthly basis
- How much money does https://www.nature.com/ generate?
- What's the income of https://www.biomedcentral.com/?
- What's the income of https://www.palgrave.com/?
- Get to know https://www.apress.com/'s earnings
- Profit of https://link.springer.com/brands/discover
- Income figures for https://www.springernature.com/gp/legal/ccpa
- What's the revenue for https://www.springernature.com/gp/info/accessibility?
- Get to know https://link.springer.com/termsandconditions's earnings
- How much cash flow does https://support.springernature.com/en/support/home have monthly?
- How much income does https://link.springer.com/legal-notice have?
- How much money does https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations generate?
- What is the earnings of https://www.springernature.com/?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
Emails and Hosting {✉️}
Mail Servers:
- mx.zoho.eu
- mx2.zoho.eu
- mx3.zoho.eu
Name Servers:
- josh.ns.cloudflare.com
- zita.ns.cloudflare.com
CDN Services {📦}
- Crossref