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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s10620-012-2311-4, but it redirected us to https://link.springer.com/article/10.1007/s10620-012-2311-4. The analysis below is for the second page.

Title[redir]:
Inhibition of Nuclear Factor-κB Enhances the Antitumor Effect of Paclitaxel Against Gastric Cancer with Peritoneal Dissemination in Mice | Digestive Diseases and Sciences
Description:
Intraperitoneal (i.p.) administration of paclitaxel is useful for treating malignant tumors with peritoneal dissemination, but the therapeutic efficacy is limited. Chemoresistance due to paclitaxel-induced nuclear factor-kappa B (NF-κB) activation is an important cause of suboptimal therapeutic efficacy. The purpose of this study was to prove that addition of nafamostat mesilate (FUT-175), a synthetic serine protease inhibitor and an NF-κB inhibitor, to i.p. paclitaxel enhances antitumor effects of paclitaxel against gastric cancer with peritoneal dissemination. In vitro, we assessed NF-κB activity and apoptosis in response to treatment with FUT-175 alone, paclitaxel alone, or a combination of FUT-175 and paclitaxel in a human gastric cancer cell line (MKN-45). In vivo, we established peritoneal dissemination in nude mice by i.p. injection of MKN-45 cells. The animals received i.p. injections of FUT-175 alone three times a week (FUT-175 group), of paclitaxel alone once a week (paclitaxel group), or a combination of FUT-175 and paclitaxel (combination group) three times and once a week, respectively. In the combination group, paclitaxel-induced NF-κB activation was inhibited and apoptosis was enhanced in comparison with those in the other groups both in vitro and in vivo. In the combination group, number and weight of peritoneal nodules were significantly lower than those in the paclitaxel group (p = 0.0009 and p = 0.0417, respectively). In the survival analysis, the combination group had a significantly better survival than the paclitaxel group (p = 0.0048). FUT-175 enhances the antitumor effect of i.p. paclitaxel against gastric cancer with peritoneal dissemination by inhibiting NF-κB activation in mice.

Matching Content Categories {📚}

  • Education
  • Science
  • Social Networks

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

google, scholar, pubmed, article, cas, cancer, paclitaxel, gastric, nuclear, peritoneal, nfkappab, cell, fut, res, combination, human, pancreatic, inhibition, dissemination, intraperitoneal, activation, nafamostat, mesilate, group, carcinoma, antitumor, mice, inhibitor, apoptosis, cells, factor, enhances, uwagawa, access, chemotherapy, clin, privacy, cookies, content, haruki, fujiwara, furukawa, paclitaxelinduced, nfκb, study, vitro, resistance, taxol, oncol, factorkappab,

Topics {✒️}

paclitaxel-induced nuclear factor-kappa month download article/chapter inhibiting nf-κb activation paclitaxel-induced nf-κb activation nuclear factor-κb enhances tnf-alpha-induced apoptosis nuclear factor-kappab p65 ryota iwase & toya ohashi assessed nf-κb activity article digestive diseases gemcitabine-induced cell death constitutively active nf-kappab nuclear factor kappa nuclear factor-kappa nuclear factor-kappab nuclear factor kappab full article pdf enhanced anti-tumor therapy nf-kappab activation privacy choices/manage cookies cell growth regulation nf-κb inhibitor mediated cell death nf-kappab complexes nf-kappab antiapoptosis paclitaxel-induced apoptosis human breast cancer reveals cell cycle advanced gastric carcinoma pathological complete response breast cancer cells systemic combined chemotherapy intraperitoneal paclitaxel combined intraperitoneal antineoplastic agents suppress caspase-8 activation synthetic protease inhibitor taxol-induced polymerization inhibits lung metastasis taxol-induced apoptosis advanced gastric cancer anti-tumor effect established peritoneal dissemination check access instant access advanced pancreatic cancer rela transcription factor european economic area treating malignant tumors suboptimal therapeutic efficacy ikappabalpha super-repressor

Schema {🗺️}

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         headline:Inhibition of Nuclear Factor-κB Enhances the Antitumor Effect of Paclitaxel Against Gastric Cancer with Peritoneal Dissemination in Mice
         description:Intraperitoneal (i.p.) administration of paclitaxel is useful for treating malignant tumors with peritoneal dissemination, but the therapeutic efficacy is limited. Chemoresistance due to paclitaxel-induced nuclear factor-kappa B (NF-κB) activation is an important cause of suboptimal therapeutic efficacy. The purpose of this study was to prove that addition of nafamostat mesilate (FUT-175), a synthetic serine protease inhibitor and an NF-κB inhibitor, to i.p. paclitaxel enhances antitumor effects of paclitaxel against gastric cancer with peritoneal dissemination. In vitro, we assessed NF-κB activity and apoptosis in response to treatment with FUT-175 alone, paclitaxel alone, or a combination of FUT-175 and paclitaxel in a human gastric cancer cell line (MKN-45). In vivo, we established peritoneal dissemination in nude mice by i.p. injection of MKN-45 cells. The animals received i.p. injections of FUT-175 alone three times a week (FUT-175 group), of paclitaxel alone once a week (paclitaxel group), or a combination of FUT-175 and paclitaxel (combination group) three times and once a week, respectively. In the combination group, paclitaxel-induced NF-κB activation was inhibited and apoptosis was enhanced in comparison with those in the other groups both in vitro and in vivo. In the combination group, number and weight of peritoneal nodules were significantly lower than those in the paclitaxel group (p = 0.0009 and p = 0.0417, respectively). In the survival analysis, the combination group had a significantly better survival than the paclitaxel group (p = 0.0048). FUT-175 enhances the antitumor effect of i.p. paclitaxel against gastric cancer with peritoneal dissemination by inhibiting NF-κB activation in mice.
         datePublished:2012-07-18T00:00:00Z
         dateModified:2012-07-18T00:00:00Z
         pageStart:123
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            Nafamostat mesilate
            Paclitaxel
            Gastric cancer
            Peritoneal dissemination
            Intraperitoneal chemotherapy
            Gastroenterology
            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
            general
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      headline:Inhibition of Nuclear Factor-κB Enhances the Antitumor Effect of Paclitaxel Against Gastric Cancer with Peritoneal Dissemination in Mice
      description:Intraperitoneal (i.p.) administration of paclitaxel is useful for treating malignant tumors with peritoneal dissemination, but the therapeutic efficacy is limited. Chemoresistance due to paclitaxel-induced nuclear factor-kappa B (NF-κB) activation is an important cause of suboptimal therapeutic efficacy. The purpose of this study was to prove that addition of nafamostat mesilate (FUT-175), a synthetic serine protease inhibitor and an NF-κB inhibitor, to i.p. paclitaxel enhances antitumor effects of paclitaxel against gastric cancer with peritoneal dissemination. In vitro, we assessed NF-κB activity and apoptosis in response to treatment with FUT-175 alone, paclitaxel alone, or a combination of FUT-175 and paclitaxel in a human gastric cancer cell line (MKN-45). In vivo, we established peritoneal dissemination in nude mice by i.p. injection of MKN-45 cells. The animals received i.p. injections of FUT-175 alone three times a week (FUT-175 group), of paclitaxel alone once a week (paclitaxel group), or a combination of FUT-175 and paclitaxel (combination group) three times and once a week, respectively. In the combination group, paclitaxel-induced NF-κB activation was inhibited and apoptosis was enhanced in comparison with those in the other groups both in vitro and in vivo. In the combination group, number and weight of peritoneal nodules were significantly lower than those in the paclitaxel group (p = 0.0009 and p = 0.0417, respectively). In the survival analysis, the combination group had a significantly better survival than the paclitaxel group (p = 0.0048). FUT-175 enhances the antitumor effect of i.p. paclitaxel against gastric cancer with peritoneal dissemination by inhibiting NF-κB activation in mice.
      datePublished:2012-07-18T00:00:00Z
      dateModified:2012-07-18T00:00:00Z
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      pageEnd:131
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         Nafamostat mesilate
         Paclitaxel
         Gastric cancer
         Peritoneal dissemination
         Intraperitoneal chemotherapy
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
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            name:Koichiro Haruki
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                     type:PostalAddress
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                  name:The Jikei University School of Medicine
                  address:
                     name:Department of Gene Therapy, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
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            type:Person
            name:Yuki Fujiwara
            affiliation:
                  name:The Jikei University School of Medicine
                  address:
                     name:Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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External Links {🔗}(234)

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Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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