DOI . ORG {}

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We began analyzing https://link.springer.com/article/10.1007/s10555-024-10232-4, but it redirected us to https://link.springer.com/article/10.1007/s10555-024-10232-4. The analysis below is for the second page.

Title[redir]:
Correlative studies reveal factors contributing to successful CAR-T cell therapies in cancer | Cancer and Metastasis Reviews
Description:
Cellular and targeted immunotherapies have revolutionized cancer treatments in the last several decades. Successful cellular therapies require both effective and durable cytotoxic activity from the immune cells as well as an accessible and susceptible response from targeted cancer cells. Correlative studies from clinical trials as well as real-world data from FDA-approved therapies have revealed invaluable insights about immune cell factors and cancer cell factors that impact rates of response and relapse to cellular therapies. This review focuses on the flagship cellular therapy of engineered chimeric antigen receptor T-cells (CAR-T cells). Within the CAR-T cell compartment, we discuss discoveries about T-cell phenotype, transcriptome, epigenetics, cytokine signaling, and metabolism that inform the cell manufacturing process to produce the most effective and durable CAR-T cells. Within the cancer cell compartment, we discuss mechanisms of resistance and relapse caused by mutations, alternative splicing, post-transcriptional modifications, and cellular reprogramming. Continued correlative and mechanistic studies are required to help us further optimize cellular therapies in a variety of malignancies.

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Science
Health & Fitness
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🌠 Phenomenal Traffic: 5M - 10M visitors per month

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Keywords {🔍}

cell, car, cells, cancer, nature, cart, therapy, leukemia, journal, medicine, article, antigen, httpsdoiorgs, blood, tcell, acute, lymphoblastic, resistance, chimeric, receptor, immunotherapy, mackall, discovery, wang, pubmed, zhang, therapies, clinical, relapse, bcell, patients, chen, factors, cellular, oncology, lymphoma, shah, scholar, function, england, children, young, httpsdoiorgblood, sadelain, google, httpsdoiorgsz, ball, research, tisagenlecleucel, cas,

Topics {✒️}

/suv39h1-ablation-enhances-long-term-car-t-function weber suv39h1-mediated-h3k9-methylation lópez-cobo target-antigen-density-improves-car jacoby cd34+cd19−cd22+ b-cell progenitors 010/attachment/92e3fa39-8112-4573-a1f5-8d938b787c95/mmc3 cd19 car-t-cell therapy decade-long leukaemia remissions myeloid lineage switch anti-gd2 car t-cells genome-wide crispr screens acute lymphoblastic leukaemia month download article/chapter car t-cell cytotoxicity car t-cell therapy anti-cd19/cd3 bite kmt2a-rearranged acute leukemia long-duration complete remissions b-cell lymphoblastic leukemia refractory b-cell lymphoma cd19-negative myeloid phenotype unchecked batf3-induced car intraventricular b7-h3 car refractory high-risk neuroblastoma chimeric antigen receptor central memory cells anti-cd19-targeted immunotherapies long-term follow recurrent high-grade glioma cells targeting b7-h3 real-world data durable cytotoxic activity immune cell factors t-cell phenotype acute lymphoblastic leukemia nr4a transcription factors induces adaptive resistance t-cell therapies orthogonal crispr screens cd19-targeted car immunotherapy target antigen loss target tumor killing cd19 enables resistance generate receptor-engineered integrated drug profiling il-13rα2-targeting car cd19-directed therapies metastasis reviews aims car t-cells cancer cell factors vivo culture improves

Questions {❓}

Will CAR T cell therapy have a role in AML?

Schema {🗺️}

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