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Title[redir]:
CDK4/6 inhibitors in advanced hormone receptor-positive/HER2-negative breast cancer: a systematic review and meta-analysis of randomized trials | Breast Cancer Research and Treatment
Description:
Purpose Combining CDK4/6 inhibitors and endocrine therapy (ET) improved outcomes for the treatment of metastatic HR+/HER2β breast cancers. Here, we performed a meta-analysis of randomized clinical trials (RCTs) to better define the benefit and the risk of CDK4/6 inhibitors plus ET for endocrine-sensitive or endocrine-resistant population in metastatic HR+/HER2β breast cancer. Method A systematic literature search of Pubmed, Embase, and the Cochrane Library was carried out up to 30 June 2018. Hazard ratios (HRs) and 95% confidence intervals (CIs) for progression-free survival (PFS), as well as odds ratios (ORs) for objective response rates, β₯βG3βG4 adverse events (AEs), and G3βG4 neutropenia were calculated for each trial. A meta-analysis was carried out using the random-effects model. Results Eight RCTs were eligible including 4578 breast cancer patients. Adding CDK4/6 inhibitors to ET in endocrine-sensitive (HR 0.55, 95% CI 0.50β0.62) or endocrine-resistant setting (HR 0.51, 95% CI 0.43β0.61) significantly improved the PFS of metastatic HR+/HER2β breast cancers regardless of menopausal status and site of metastasis. Moreover, CDK4/6 inhibitors plus ET meaningfully improved objective response rate in endocrine-sensitive (ORs 0.62, 95% CI 0.52β0.73) or endocrine-resistant setting (ORs 0.33, 95% CI 0.24β0.47). The use of these drugs was characterized by a significant increase of G3βG4 AEs (OR 10.88, 95% CI 6.53β18.14). Conclusion Emerging data provide a new standard treatment for advanced HR+/HER2β breast cancer, regardless of menopausal status, prior hormonal/chemotherapy treatments delivered, sites of metastasis. However, benefits should be balanced with longer treatment duration, toxicities, and costs.
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Keywords {π}
cancer, breast, article, google, scholar, cas, advanced, oncol, hormone, therapy, endocrine, metastatic, palbociclib, receptorpositive, metaanalysis, treatment, phase, cdk, inhibitors, carlo, receptor, clin, letrozole, harbeck, fulvestrant, systematic, review, randomized, messina, trial, patients, res, study, paloma, women, analysis, data, trials, hrher, clinical, pubmed, access, human, rugo, hernegative, iwata, ann, privacy, cookies, content,
Topics {βοΈ}
anti-cancer therapies patient-reported health-related quality hr+/her2β breast cancer metastatic breast cancer advanced breast cancer month download article/chapter hormone receptor-positive hormone-receptor-positive prior endocrine therapy-safety breast cancer statistics breast cancer markers de la cruz-merino randomized clinical trials oestrogen receptor-positive endocrine resistance οΏ½οΏ½βg3βg4 adverse events her2-negative related subjects targeted agents full article pdf cyclin-dependent kinase 4 privacy choices/manage cookies objective response rates breast cancer phase iii trial phase iii study cyclin-dependent kinases patient-reported outcomes author information authors versus endocrine therapy previous endocrine therapy receiving endocrine therapy randomized trials g3βg4 neutropenia check access instant access clinical trials carlo cattrini finn rs systematic literature search initial endocrine therapy cost-utility analysis endocrine-resistant population endocrine-resistant setting van kampen rj van den berkmortel initial palliative therapy conditions privacy policy adding cdk4/6 inhibitors random-effects model
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headline:CDK4/6 inhibitors in advanced hormone receptor-positive/HER2-negative breast cancer: a systematic review and meta-analysis of randomized trials
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