Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s10522-018-9762-8, but it redirected us to https://link.springer.com/article/10.1007/s10522-018-9762-8. The analysis below is for the second page.

Title[redir]:
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence | Biogerontology
Description:
The aging process is associated with a low-grade chronic inflammation and the accumulation of senescent cells into tissues. Diverse stresses can trigger cellular senescence, a cell fate characterized by cell-cycle arrest and flat morphology. Oncogenic signaling can also induce cellular senescence which has been termed oncogene-induced senescence (OIS). Senescent cells display a pro-inflammatory phenotype which has been called the senescence-associated secretory phenotype (SASP). The secretomes associated with SASP contain colony-stimulating factors and chemokines which stimulate the generation of myeloid-derived suppressor cells (MDSC) by enhancing myelopoiesis in bone marrow and spleen. Enhanced myelopoiesis and increased level of MDSCs have been observed in bone marrow, spleen, and blood in both tumor-bearing and aged mice. Immunosuppressive MDSCs are recruited via chemotaxis into inflamed tissues where they proliferate and consequently suppress acute inflammatory reactions by inhibiting the functions of distinct components of innate and adaptive immunity. For instance, MDSCs stimulate the activity of immunosuppressive regulatory T-cells (Tregs). They also increase the expression of amino acid catabolizing enzymes and the secretion of anti-inflammatory cytokines, e.g. IL-10 and TGF-β, and reactive oxygen species (ROS). On the other hand, the accumulation of MDSCs into tissues exerts harmful effects in chronic pathological disorders, e.g. tumors and many age-related diseases, since the immunosuppression induced by MDSCs impairs the clearance of senescent and cancer cells and also disturbs the maintenance of energy metabolism and tissue proteostasis. The co-operation between senescent cells and immunosuppressive MDSCs regulates not only tumorigenesis and chronic inflammatory disorders but it also might promote inflammaging during the aging process.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We don’t know how the website earns money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cas, cells, central, suppressor, myeloidderived, cell, senescence, cancer, aging, immunol, cellular, senescent, tumor, biol, myeloid, ageing, wang, res, rev, campisi, inflammation, mdscs, human, role, liu, inflammatory, nat, immune, regulatory, phenotype, secretory, macrophages, van, zhang, bone, marrow, mice, stem, disease, trends, chen, yang, finland, function, accumulation, signaling,

Topics {✒️}

hematopoietic stem cells cxcl2/mif-cxcr2 signaling promotes muscle-derived nitric oxide myeloid-derived suppressor cells month download article/chapter cell surface-bound il-1α human dendritic cells decreased tnf-α synthesis cell-mediated liver injury myeloid-derived cells myeloid suppressor cells immunosuppressive regulatory t-cells immature myeloid cells molecular structure-functional activity /ebpβ enhances nf-κb pge2-induced cxcl12 production termed oncogene-induced senescence oncogene-induced senescence relayed interleukin-dependent inflammatory network low-grade chronic inflammation nf-κb-dependent mechanism /ebpβ transcription factor de keizer plj article biogerontology aims full article pdf dendritic cells il-6/il-8 cytokine network pleiotropic-inflamed monocytes/macrophages age-related degenerative disease davalos ar promote macrophage migration induce cellular senescence reactive oxygen species alternately activated macrophages induces cellular senescence morales-rosales sl retinoblastoma tumor suppressor van deursen jm privacy choices/manage cookies dna damage response immune-suppressive cells article salminen childs bg burton dg limits tumor progression van de sluis senescent cells display targeting senescent cells p53 tumor suppressor impair antitumor immunity

Questions {❓}

  • Campisi J, Andersen JK, Kapahi P, Melov S (2011) Cellular senescence: a link between cancer and age-related degenerative disease?
  • Goh C, Narayanan S, Hahn YS (2013) Myeloid-derived suppressor cells: the dark knight or the joker in viral infections?
  • De Keizer PL (2017) The fountain of youth by targeting senescent cells?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
         description:The aging process is associated with a low-grade chronic inflammation and the accumulation of senescent cells into tissues. Diverse stresses can trigger cellular senescence, a cell fate characterized by cell-cycle arrest and flat morphology. Oncogenic signaling can also induce cellular senescence which has been termed oncogene-induced senescence (OIS). Senescent cells display a pro-inflammatory phenotype which has been called the senescence-associated secretory phenotype (SASP). The secretomes associated with SASP contain colony-stimulating factors and chemokines which stimulate the generation of myeloid-derived suppressor cells (MDSC) by enhancing myelopoiesis in bone marrow and spleen. Enhanced myelopoiesis and increased level of MDSCs have been observed in bone marrow, spleen, and blood in both tumor-bearing and aged mice. Immunosuppressive MDSCs are recruited via chemotaxis into inflamed tissues where they proliferate and consequently suppress acute inflammatory reactions by inhibiting the functions of distinct components of innate and adaptive immunity. For instance, MDSCs stimulate the activity of immunosuppressive regulatory T-cells (Tregs). They also increase the expression of amino acid catabolizing enzymes and the secretion of anti-inflammatory cytokines, e.g. IL-10 and TGF-β, and reactive oxygen species (ROS). On the other hand, the accumulation of MDSCs into tissues exerts harmful effects in chronic pathological disorders, e.g. tumors and many age-related diseases, since the immunosuppression induced by MDSCs impairs the clearance of senescent and cancer cells and also disturbs the maintenance of energy metabolism and tissue proteostasis. The co-operation between senescent cells and immunosuppressive MDSCs regulates not only tumorigenesis and chronic inflammatory disorders but it also might promote inflammaging during the aging process.
         datePublished:2018-06-29T00:00:00Z
         dateModified:2018-06-29T00:00:00Z
         pageStart:325
         pageEnd:339
         sameAs:https://doi.org/10.1007/s10522-018-9762-8
         keywords:
            Ageing
            Cancer
            Immunosenescence
            Inflammaging
            Longevity
            Oxidative stress
            Cell Biology
            Geriatrics/Gerontology
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-018-9762-8/MediaObjects/10522_2018_9762_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-018-9762-8/MediaObjects/10522_2018_9762_Fig2_HTML.png
         isPartOf:
            name:Biogerontology
            issn:
               1573-6768
               1389-5729
            volumeNumber:19
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Antero Salminen
               affiliation:
                     name:University of Eastern Finland
                     address:
                        name:Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Anu Kauppinen
               affiliation:
                     name:University of Eastern Finland
                     address:
                        name:School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kai Kaarniranta
               affiliation:
                     name:University of Eastern Finland
                     address:
                        name:Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
                        type:PostalAddress
                     type:Organization
                     name:Kuopio University Hospital (KYS)
                     address:
                        name:Department of Ophthalmology, Kuopio University Hospital (KYS), Kuopio, Finland
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
      description:The aging process is associated with a low-grade chronic inflammation and the accumulation of senescent cells into tissues. Diverse stresses can trigger cellular senescence, a cell fate characterized by cell-cycle arrest and flat morphology. Oncogenic signaling can also induce cellular senescence which has been termed oncogene-induced senescence (OIS). Senescent cells display a pro-inflammatory phenotype which has been called the senescence-associated secretory phenotype (SASP). The secretomes associated with SASP contain colony-stimulating factors and chemokines which stimulate the generation of myeloid-derived suppressor cells (MDSC) by enhancing myelopoiesis in bone marrow and spleen. Enhanced myelopoiesis and increased level of MDSCs have been observed in bone marrow, spleen, and blood in both tumor-bearing and aged mice. Immunosuppressive MDSCs are recruited via chemotaxis into inflamed tissues where they proliferate and consequently suppress acute inflammatory reactions by inhibiting the functions of distinct components of innate and adaptive immunity. For instance, MDSCs stimulate the activity of immunosuppressive regulatory T-cells (Tregs). They also increase the expression of amino acid catabolizing enzymes and the secretion of anti-inflammatory cytokines, e.g. IL-10 and TGF-β, and reactive oxygen species (ROS). On the other hand, the accumulation of MDSCs into tissues exerts harmful effects in chronic pathological disorders, e.g. tumors and many age-related diseases, since the immunosuppression induced by MDSCs impairs the clearance of senescent and cancer cells and also disturbs the maintenance of energy metabolism and tissue proteostasis. The co-operation between senescent cells and immunosuppressive MDSCs regulates not only tumorigenesis and chronic inflammatory disorders but it also might promote inflammaging during the aging process.
      datePublished:2018-06-29T00:00:00Z
      dateModified:2018-06-29T00:00:00Z
      pageStart:325
      pageEnd:339
      sameAs:https://doi.org/10.1007/s10522-018-9762-8
      keywords:
         Ageing
         Cancer
         Immunosenescence
         Inflammaging
         Longevity
         Oxidative stress
         Cell Biology
         Geriatrics/Gerontology
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-018-9762-8/MediaObjects/10522_2018_9762_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-018-9762-8/MediaObjects/10522_2018_9762_Fig2_HTML.png
      isPartOf:
         name:Biogerontology
         issn:
            1573-6768
            1389-5729
         volumeNumber:19
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Antero Salminen
            affiliation:
                  name:University of Eastern Finland
                  address:
                     name:Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Anu Kauppinen
            affiliation:
                  name:University of Eastern Finland
                  address:
                     name:School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kai Kaarniranta
            affiliation:
                  name:University of Eastern Finland
                  address:
                     name:Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
                     type:PostalAddress
                  type:Organization
                  name:Kuopio University Hospital (KYS)
                  address:
                     name:Department of Ophthalmology, Kuopio University Hospital (KYS), Kuopio, Finland
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Biogerontology
      issn:
         1573-6768
         1389-5729
      volumeNumber:19
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Eastern Finland
      address:
         name:Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
         type:PostalAddress
      name:University of Eastern Finland
      address:
         name:School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
         type:PostalAddress
      name:University of Eastern Finland
      address:
         name:Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
         type:PostalAddress
      name:Kuopio University Hospital (KYS)
      address:
         name:Department of Ophthalmology, Kuopio University Hospital (KYS), Kuopio, Finland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Antero Salminen
      affiliation:
            name:University of Eastern Finland
            address:
               name:Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Anu Kauppinen
      affiliation:
            name:University of Eastern Finland
            address:
               name:School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
               type:PostalAddress
            type:Organization
      name:Kai Kaarniranta
      affiliation:
            name:University of Eastern Finland
            address:
               name:Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
               type:PostalAddress
            type:Organization
            name:Kuopio University Hospital (KYS)
            address:
               name:Department of Ophthalmology, Kuopio University Hospital (KYS), Kuopio, Finland
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
      name:School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
      name:Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
      name:Department of Ophthalmology, Kuopio University Hospital (KYS), Kuopio, Finland
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(577)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Foundation
  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

4.8s.