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month download article/chapter gene encoding alpha-synuclein alpha-synuclein locus duplication alpha-synuclein gene duplication alpha-synuclein gene identified alpha-synuclein mrna expression full length alpha-synuclein plasma alpha-synuclein levels plasma α-synuclein levels plasma amyloid-beta efflux full article pdf kilford aj lees leroy se ide dc%2bd3cxjsloqs7k%3d 10 dc%2bd2cxnvvoiu7y%3d 10 dc%2bd38xitlgkt7g%3d 10 dc%2bd3sxks1alsrw%3d 10 dc%2bd3sxkvvkqt7w%3d 10 dc%2bd2cxnvvoiu7c%3d 10 dc%2bd2cxhs1sgtb0%3d 10 hardy mr cookson privacy choices/manage cookies overt neurodegeneration back ikeda mr cookson alpha-synuclein structure alpha-synuclein implicated dyak1cznvf2htw%3d%3d 10 dyak1cxosfcnta%3d%3d 10 beta-amyloid peptide42 α-synuclein level article journal multiple system atrophy multiple-system atrophy multiple system atrophy yew ml teoh α-synuclein disease article log european economic area scope submit manuscript barbieri vl buchman van der putten extracellular biological fluids przuntek jt epplen boyer es stenroos lazzarini rc duvoisin ajou university school article lee brain amyloid burden conditions privacy policy neural transmission aims

Questions {❓}

• WP Gai JH Power PC Blumbergs WW Blessing (1998) Multiple-system atrophy: a new α-synuclein disease?
• α-Synuclein in Parkinson’s disease: causal or bystander?

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         headline:The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy
         description:α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson’s disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.
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