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Keywords {🔍}

pubmed, google, scholar, disease, patients, crohns, colitis, bowel, cas, treatment, inflammatory, ulcerative, gastroenterol, remission, therapy, ibd, study, risk, metaanalysis, clinical, review, statements, central, gastroenterology, systematic, antitnfα, vedolizumab, agents, induction, efficacy, maintenance, endoscopic, reported, dis, clin, reference, diagnosis, statement, made, active, safety, evidence, guidelines, recommendation, studies, asa, hepatol, severe, combination, effective,

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hla-dqa1-hla-drb1 polymorphism anti-tnf-α antibody products availability/fda-approves-boxed-warning anti-tnf-α agents efficacious anti-tnf-α antibody agents anti-tnf-α agents prevent anti-tnf-α antibody therapy anti-tnf-α agents administered anti-tnf-α agent effective pre-illness isoflavone consumption anti-tnf-alpha agents anti-tnf-α agents anti-tnf α agents left-sided uc starting hepatosplenic t-cell lymphoma anti-tnf-α agent bacillus calmette–guérin vaccine anti-il-12/23p40 antibodies received anti-tnfα agents delayed-release oral mesalamine left-sided colitis type discontinuating anti-tnfα agents article download pdf meta-analytic study denied oral slow-release mesalazine european evidenced-based consensus blood-cell removal therapy ileo-anal pouch disorders nonsteroidal anti-inflammatory drug fewer anti-drug antibodies nonsteroidal anti-inflammatory drugs irritable bowel syndrome european evidence-based consensus high-definition white-light endoscopy ileal pouch-anal anastomosis received scholarship/research grant remitting/relapsing inflammatory diseases combination anti-tnfα agents international omed-ecco consensus global post-marketing data multicenter case-control study multicenter long-term follow long-term oral contraceptive meta-analytic study showed anti-tnfα agents effective sham-controlled clinical trial adalimumab-induced mucosal healing cross-sectional studies comparing nationwide case-control study potent anti-inflammatory effects

Questions {❓}

• Are 5-ASA suppositories useful for the induction of remission in mild to moderately active UC of the proctitis type?
• Are anti-TNF-α agents efficacious for pouchitis?
• Are anti-TNF-α agents useful for the treatment of internal fistulas in CD?
• Are anti-TNFα agents effective for patients refractory to vedolizumab?
• Are fecal calprotectin tests and fecal immunochemical tests (FITs) useful for assessing disease activity in UC patients in remission?
• Are oral and topical 5-ASA formulations useful for the induction of remission in mild to moderately active UC?
• Are random biopsies still useful for the detection of neoplasia in patients with IBD undergoing surveillance colonoscopy with chromoendoscopy?
• BQ 1 What is IBD?
• BQ 24 Are steroids (PSL, budesonide) useful for induction therapy for CD?
• CQ 11: Is tofacitinib effective for UC patients refractory to anti-TNFα agents?
• CQ 13: Who should receive surveillance colonoscopy for detecting CRC in UC?
• Can anti-TNF α agents be stopped?
• Can endoscopic balloon dilation (EBD) for intestinal stenosis in CD avoid surgical intervention?
• Do anti-TNF-α agents prevent the recurrence of CD after surgery?
• Does 5-ASA treatment reduce the risk of UC-associated colorectal cancer (CRC)?
• Does anti-tumor necrosis factor alpha prevent the recurrence of Crohn’s disease?
• How do you deal with elderly IBD patients?
• How do you deal with patients with IBD during pregnancy and lactation?
• How do you proceed with the diagnosis of IBD?
• How is cancer surveillance performed for CD?
• Is MRI useful for the evaluation of CD disease activity?
• Is SBCE useful for the assessment of small bowel disease activity in CD?
• Is an anti-TNF-α agent useful for CD with GI bleeding?
• Is budesonide foam useful for UC?
• Is concomitant use of immunomodulators and anti-TNF-α agents useful in the treatment of patients with IBD?
• Is endoscopic treatment recommended for colitis-associated cancer/dysplasia in patients with IBD?
• Is fecal calprotectin testing useful for the differential diagnosis of IBD?
• Is maintenance treatment with 5-ASA drugs for UC in remission useful in maintaining clinical and endoscopic remission?
• Is retreatment with the same anti-TNF-α agent effective and safe for the relapse after one discontinuation?
• Is tacrolimus treatment effective for CD?
• Is the NUDT15 gene R139C variant useful for predicting acute severe leukopenia induced by thiopurine?
• Is the combined use of 5-ASA with biologics or immunomodulators (IMs) for CD in remission useful?
• Is the concomitant use of an immunomodulator with ustekinumab more useful than ustekinumab monotherapy as an induction therapy for CD?
• Is the long-term combination of anti-TNF-α agents and immunomodulaors safe?
• Is there a difference in the effectiveness of Infliximab (originator) and biosimilars in introducing and maintaining remission?
• Is thiopurine associated with an increased incidence of lymphoma in Asian IBD patients?
• Is thiopurine effective for the prevention of postoperative recurrence of CD?
• Is thromboembolism prophylaxis necessary for hospitalized IBD patients?
• Is tofacitinib useful for refractory patients with moderate to severely active UC?
• Is ustekinumab safe for pregnant women with CD?
• Is ustekinumab useful for perianal lesions of CD?
• Is ustekinumab useful for preventing postoperative recurrence in CD?
• Is ustekinumab useful for treating CD?
• Is vedolizumab effective for CD?
• Is vedolizumab effective for IBD patients refractory to anti-TNFα agents?
• Is vedolizumab effective for UC?
• Is “complete” remission the new treatment paradigm?
• Should vedolizumab be used with immunomodulators in IBD patients?
• Should we use vedolizumab as mono or combo therapy in ulcerative colitis?
• What are imaging studies other than endoscopy are used to diagnose CD?
• What are nonendoscopic, noninvasive tests used in the diagnosis of UC?
• What are the benefits and cautions of Cytapheresis (CAP) in the treatment of IBD?
• What are the benefits and caveats of nutritional therapy in the treatment of IBD?
• What are the benefits and precautions for the use of 5-ASA drugs in the treatment of IBD?
• What are the benefits and precautions for the use of anti-TNF-α agents in the treatment of IBD?
• What are the benefits and precautions for the use of calcineurin inhibitors in the treatment of IBD?
• What are the diagnostic criteria for IBD?
• What are the extraintestinal complications observed in patients with IBD?
• What are the factors that contribute to and exacerbate IBD?
• What are the indications and precautions for the surgical treatment of IBD?
• What are the precautions to take when using immunosuppressive drugs?
• What are the precautions to take when using tofacitinib in UC treatment?
• What are the usefulness and precaution for the use of immunomodulators in the treatment of IBD?
• What is the appropriate maintenance dose of 5-ASA for treating UC?
• What is the epidemiology of IBD in Japan?
• What is the pathology, classification, and severity of CD?
• What is the pathology, classification, and severity of UC?
• What is the role of endoscopy in the diagnosis and treatment of CD?
• What is the role of endoscopy in the diagnosis and treatment of UC?
• What is the usefulness and precautions for the use of corticosteroids in IBD treatment?
• What is “Treat to Target” (T2T) in IBD treatment?
• What kind of biopsy method is recommended for UC-associated CRC surveillance?
• What should we consider in the safety of vedolizumab?

Schema {🗺️}

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      headline:Evidence-based clinical practice guidelines for inflammatory bowel disease 2020
      description:Inflammatory bowel disease (IBD) is a general term for chronic or remitting/relapsing inflammatory diseases of the intestinal tract and generally refers to ulcerative colitis (UC) and Crohn’s disease (CD). Since 1950, the number of patients with IBD in Japan has been increasing. The etiology of IBD remains unclear; however, recent research data indicate that the pathophysiology of IBD involves abnormalities in disease susceptibility genes, environmental factors and intestinal bacteria. The elucidation of the mechanism of IBD has facilitated therapeutic development. UC and CD display heterogeneity in inflammatory and symptomatic burden between patients and within individuals over time. Optimal management depends on the understanding and tailoring of evidence-based interventions by physicians. In 2020, seventeen IBD experts of the Japanese Society of Gastroenterology revised the previous guidelines for IBD management published in 2016. This English version was produced and modified based on the existing updated guidelines in Japanese. The Clinical Questions (CQs) of the previous guidelines were completely revised and categorized as follows: Background Questions (BQs), CQs, and Future Research Questions (FRQs). The guideline was composed of a total of 69 questions: 39 BQs, 15 CQs, and 15 FRQs. The overall quality of the evidence for each CQ was determined by assessing it with reference to the Grading of Recommendations Assessment, Development and Evaluation approach, and the strength of the recommendation was determined by the Delphi consensus process. Comprehensive up-to-date guidance for on-site physicians is provided regarding indications for proceeding with the diagnosis and treatment.
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      dateModified:2021-04-22T00:00:00Z
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         Inflammatory bowel disease
         Steroid
         Immunomodulators
         Biologics
         Gastroenterology
         Hepatology
         Abdominal Surgery
         Colorectal Surgery
         Surgical Oncology
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         name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
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      address:
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            name:The Japanese Society of Gastroenterology
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            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
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            type:Organization
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            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
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               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
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            name:The Japanese Society of Gastroenterology
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               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
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            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
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            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
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      name:Nagamu Inoue
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
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      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Makoto Naganuma
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Tadakazu Hisamatsu
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Mamoru Watanabe
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Hiroto Miwa
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Nobuyuki Enomoto
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Tooru Shimosegawa
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Kazuhiko Koike
      affiliation:
            name:The Japanese Society of Gastroenterology
            address:
               name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan
      name:Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease”, The Japanese Society of Gastroenterology, Tokyo, Japan

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