DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Questions
Schema
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00441-010-1018-0, but it redirected us to https://link.springer.com/article/10.1007/s00441-010-1018-0. The analysis below is for the second page.

Title[redir]:
Pentraxins in innate immunity: lessons from PTX3 | Cell and Tissue Research
Description:
The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive immunity. The innate immune system is composed of a cellular arm and a humoral arm. Components of the humoral arm include members of the complement cascade and soluble pattern recognition molecules (PRMs). These fluid-phase PRMs represent the functional ancestors of antibodies and play a crucial role in the discrimination between self, non-self and modified-self. Moreover, evidence has been presented that these soluble PRMs participate in the regulation of inflammatory responses and interact with the cellular arm of the innate immune system. Pentraxins consist of a set of multimeric soluble proteins and represent the prototypic components of humoral innate immunity. Based on the primary structure of the protomer, pentraxins are divided into two groups: short pentraxins and long pentraxins. The short pentraxins C-reactive protein and serum amyloid P-component are produced by the liver and represent the main acute phase proteins in human and mouse, respectively. The long pentraxin PTX3 is produced by innate immunity cells (e.g. PMN, macrophages, dendritic cells), interacts with several ligands and plays an essential role in innate immunity, tuning inflammation and matrix deposition. PTX3 provides a paradigm for the mode of action of humoral innate immunity.

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 80,904,851 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

google, scholar, pubmed, cas, mantovani, pentraxin, ptx, protein, innate, long, creactive, bottazzi, immunol, immunity, garlanda, peri, cells, biol, complement, pentraxins, amyloid, doni, recognition, serum, immune, human, van, humoral, chem, component, activation, regulation, med, article, inflammation, cell, deban, role, jaillon, pattern, acute, exp, introna, expression, plasma, disease, bastone, salvatori, response, research,

Topics {✒️}

high-sensitivity c-reactive protein aids complement-mediated immunity month download article/chapter anti-aspergillus fumigatus efficacy sialic acid-binding lectin tumor necrosis factor-alpha pattern recognition receptors atherogenic lipid profile tnfalpha-induced secreted protein c-reactive protein collaborates ifn-gamma-inducible protein 10 human c-reactive protein c-reactive protein levels santos cc dos membrane-bound complement inhibitors c-reactive protein binds interferon-gamma inhibits expression humoral innate immunity innate immune system innate immune defense privacy choices/manage cookies tumor necrosis factor livija deban interleukin-1-inducible genes innate immunity cells integrated view serum amyloid p-component dos santos jl tissue research aims related subjects c-reactive protein fluid-phase prms represent late apoptotic neutrophils prevents antinuclear autoimmunity full article pdf boost immune response component prevents proteolysis mammalian scavenger receptors ischemic vascular disease alveolar epithelial cells anti-ptx3 autoantibodies persisting high levels fcgamma receptor ii acute myocardial infarction pathway activation cellular innate immunity elevated maternal levels european research council complement dependent amplification seizure-induced neurodegeneration

Questions {❓}

Gillmore JD, Hutchinson WL, Herbert J, Bybee A, Mitchell DA, Hasserjian RP, Yamamura K, Suzuki M, Sabin CA, Pepys MB (2004) Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?
Miyaki A, Maeda S, Yoshizawa M, Misono M, Sasai H, Shimojo N, Tanaka K, Ajisaka R (2010) Is pentraxin 3 involved in obesity-induced decrease in arterial distensibility?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Pentraxins in innate immunity: lessons from PTX3
         description:The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive immunity. The innate immune system is composed of a cellular arm and a humoral arm. Components of the humoral arm include members of the complement cascade and soluble pattern recognition molecules (PRMs). These fluid-phase PRMs represent the functional ancestors of antibodies and play a crucial role in the discrimination between self, non-self and modified-self. Moreover, evidence has been presented that these soluble PRMs participate in the regulation of inflammatory responses and interact with the cellular arm of the innate immune system. Pentraxins consist of a set of multimeric soluble proteins and represent the prototypic components of humoral innate immunity. Based on the primary structure of the protomer, pentraxins are divided into two groups: short pentraxins and long pentraxins. The short pentraxins C-reactive protein and serum amyloid P-component are produced by the liver and represent the main acute phase proteins in human and mouse, respectively. The long pentraxin PTX3 is produced by innate immunity cells (e.g. PMN, macrophages, dendritic cells), interacts with several ligands and plays an essential role in innate immunity, tuning inflammation and matrix deposition. PTX3 provides a paradigm for the mode of action of humoral innate immunity.
         datePublished:2010-08-04T00:00:00Z
         dateModified:2010-08-04T00:00:00Z
         pageStart:237
         pageEnd:249
         sameAs:https://doi.org/10.1007/s00441-010-1018-0
         keywords:
            Innate immunity
            Inflammation
            Pattern recognition
            Pentraxins
            PTX3
            Human Genetics
            Proteomics
            Molecular Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00441-010-1018-0/MediaObjects/441_2010_1018_Fig1_HTML.gif
         isPartOf:
            name:Cell and Tissue Research
            issn:
               1432-0878
               0302-766X
            volumeNumber:343
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Livija Deban
               affiliation:
                     name:Istituto Clinico Humanitas IRCCS
                     address:
                        name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sebastien Jaillon
               affiliation:
                     name:Istituto Clinico Humanitas IRCCS
                     address:
                        name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cecilia Garlanda
               affiliation:
                     name:Istituto Clinico Humanitas IRCCS
                     address:
                        name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Barbara Bottazzi
               affiliation:
                     name:Istituto Clinico Humanitas IRCCS
                     address:
                        name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alberto Mantovani
               affiliation:
                     name:Istituto Clinico Humanitas IRCCS
                     address:
                        name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                        type:PostalAddress
                     type:Organization
                     name:University of Milan
                     address:
                        name:Department of Translational Medicine, University of Milan, Rozzano, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Pentraxins in innate immunity: lessons from PTX3
      description:The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive immunity. The innate immune system is composed of a cellular arm and a humoral arm. Components of the humoral arm include members of the complement cascade and soluble pattern recognition molecules (PRMs). These fluid-phase PRMs represent the functional ancestors of antibodies and play a crucial role in the discrimination between self, non-self and modified-self. Moreover, evidence has been presented that these soluble PRMs participate in the regulation of inflammatory responses and interact with the cellular arm of the innate immune system. Pentraxins consist of a set of multimeric soluble proteins and represent the prototypic components of humoral innate immunity. Based on the primary structure of the protomer, pentraxins are divided into two groups: short pentraxins and long pentraxins. The short pentraxins C-reactive protein and serum amyloid P-component are produced by the liver and represent the main acute phase proteins in human and mouse, respectively. The long pentraxin PTX3 is produced by innate immunity cells (e.g. PMN, macrophages, dendritic cells), interacts with several ligands and plays an essential role in innate immunity, tuning inflammation and matrix deposition. PTX3 provides a paradigm for the mode of action of humoral innate immunity.
      datePublished:2010-08-04T00:00:00Z
      dateModified:2010-08-04T00:00:00Z
      pageStart:237
      pageEnd:249
      sameAs:https://doi.org/10.1007/s00441-010-1018-0
      keywords:
         Innate immunity
         Inflammation
         Pattern recognition
         Pentraxins
         PTX3
         Human Genetics
         Proteomics
         Molecular Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00441-010-1018-0/MediaObjects/441_2010_1018_Fig1_HTML.gif
      isPartOf:
         name:Cell and Tissue Research
         issn:
            1432-0878
            0302-766X
         volumeNumber:343
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Livija Deban
            affiliation:
                  name:Istituto Clinico Humanitas IRCCS
                  address:
                     name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sebastien Jaillon
            affiliation:
                  name:Istituto Clinico Humanitas IRCCS
                  address:
                     name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cecilia Garlanda
            affiliation:
                  name:Istituto Clinico Humanitas IRCCS
                  address:
                     name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Barbara Bottazzi
            affiliation:
                  name:Istituto Clinico Humanitas IRCCS
                  address:
                     name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alberto Mantovani
            affiliation:
                  name:Istituto Clinico Humanitas IRCCS
                  address:
                     name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
                     type:PostalAddress
                  type:Organization
                  name:University of Milan
                  address:
                     name:Department of Translational Medicine, University of Milan, Rozzano, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cell and Tissue Research
      issn:
         1432-0878
         0302-766X
      volumeNumber:343
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Istituto Clinico Humanitas IRCCS
      address:
         name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
         type:PostalAddress
      name:Istituto Clinico Humanitas IRCCS
      address:
         name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
         type:PostalAddress
      name:Istituto Clinico Humanitas IRCCS
      address:
         name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
         type:PostalAddress
      name:Istituto Clinico Humanitas IRCCS
      address:
         name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
         type:PostalAddress
      name:Istituto Clinico Humanitas IRCCS
      address:
         name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
         type:PostalAddress
      name:University of Milan
      address:
         name:Department of Translational Medicine, University of Milan, Rozzano, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Livija Deban
      affiliation:
            name:Istituto Clinico Humanitas IRCCS
            address:
               name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
               type:PostalAddress
            type:Organization
      name:Sebastien Jaillon
      affiliation:
            name:Istituto Clinico Humanitas IRCCS
            address:
               name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
               type:PostalAddress
            type:Organization
      name:Cecilia Garlanda
      affiliation:
            name:Istituto Clinico Humanitas IRCCS
            address:
               name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
               type:PostalAddress
            type:Organization
      name:Barbara Bottazzi
      affiliation:
            name:Istituto Clinico Humanitas IRCCS
            address:
               name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
               type:PostalAddress
            type:Organization
      name:Alberto Mantovani
      affiliation:
            name:Istituto Clinico Humanitas IRCCS
            address:
               name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
               type:PostalAddress
            type:Organization
            name:University of Milan
            address:
               name:Department of Translational Medicine, University of Milan, Rozzano, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
      name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
      name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
      name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
      name:Istituto Clinico Humanitas IRCCS, Rozzano, Italy
      name:Department of Translational Medicine, University of Milan, Rozzano, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(406)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Crossref

4.76s.