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We began analyzing https://link.springer.com/article/10.1007/s004360000242, but it redirected us to https://link.springer.com/article/10.1007/s004360000242. The analysis below is for the second page.

Title[redir]:
Growth-inhibitory effects of interferon-γ on Neospora caninum in murine macrophages by a nitric oxide mechanism | Parasitology Research
Description:
To clarify the effector pathway of Neospora caninum growth-inhibitory activity induced by interferon-γ (IFN-γ) in murine macrophages we examined the relationship between IFN-γ and nitric oxide (NO). Production of NO was enhanced in cultures of macrophages supplemented with IFN-γ, and dose-dependent growth inhibition was observed. These findings suggest that the inhibitory activity induced in macrophages by IFN-γ is mediated NO molecules. A competitive inhibitor of the L-arginine-dependent effector pathway, N G-monomethyl-L-arginine, virtually abolished the inhibitory effects induced by IFN-γ. From this finding it appears that the inhibitory effects induced by IFN-γ in macrophages may be mediated by an L-arginine-dependent effector pathway that involves NO production. In vivo, mice with a targeted disruption of the inducible NO synthase gene (iNOS−/−) were more susceptible than wild-type mice to N. caninum. Therefore, the production of NO in macrophages induced by IFN-γ is an important mechanism for the killing of intracellular N. caninum.

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Keywords {🔍}

article, macrophages, ifnγ, oxide, access, research, nitric, privacy, cookies, content, caninum, induced, information, publish, search, effects, murine, mechanism, activity, inhibition, inhibitory, open, data, log, journal, growthinhibitory, interferonγ, neospora, tanaka, nagasawa, fujisaki, effector, pathway, production, discover, springer, optional, personal, parties, policy, find, track, parasitology, cite, tetsuya, hideyuki, kozo, naoyoshi, suzuki, takeshi,

Topics {✒️}

interferon-gamma-stimulated melanoma progression l-arginine-dependent effector pathway dose-dependent growth inhibition growth-inhibitory effects g-monomethyl-l-arginine month download article/chapter inhibitory activity induced nitric oxide mechanism competitive inhibitor bovine monocyte-derived macrophages inhibitory effects induced ifn-γ producing cells related subjects privacy choices/manage cookies full article pdf nitric oxide european economic area protozoan molecular immunology japan e-mail conditions privacy policy check access instant access accepting optional cookies effector pathway wild-type mice article tanaka main content log journal finder publish article log article cite important mechanism neospora caninum privacy policy personal data synthase gene inhibition books a macrophages induced optional cookies manage preferences interferon-γ data protection essential cookies cookies skip subscription content similar content interferon-ɣ murine macrophages jp tel institution subscribe

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      headline:Growth-inhibitory effects of interferon-γ on Neospora caninum in murine macrophages by a nitric oxide mechanism
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