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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
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We began analyzing https://link.springer.com/article/10.1007/s00415-019-09688-0, but it redirected us to https://link.springer.com/article/10.1007/s00415-019-09688-0. The analysis below is for the second page.

Title[redir]:
Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy | Journal of Neurology
Description:
Amyloid transthyretin (ATTR) amyloidosis with polyneuropathy (PN) is a progressive, debilitating, systemic disease wherein transthyretin protein misfolds to form amyloid, which is deposited in the endoneurium. ATTR amyloidosis with PN is the most serious hereditary polyneuropathy of adult onset. It arises from a hereditary mutation in the TTR gene and may involve the heart as well as other organs. It is critical to identify and diagnose the disease earlier because treatments are available to help slow the progression of neuropathy. Early diagnosis is complicated, however, because presentation may vary and family history is not always known. Symptoms may be mistakenly attributed to other diseases such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), idiopathic axonal polyneuropathy, lumbar spinal stenosis, and, more rarely, diabetic neuropathy and AL amyloidosis. In endemic countries (e.g., Portugal, Japan, Sweden, Brazil), ATTR amyloidosis with PN should be suspected in any patient who has length-dependent small-fiber PN with autonomic dysfunction and a family history of ATTR amyloidosis, unexplained weight loss, heart rhythm disorders, vitreous opacities, or renal abnormalities. In nonendemic countries, the disease may present as idiopathic rapidly progressive sensory motor axonal neuropathy or atypical CIDP with any of the above symptoms or with bilateral carpal tunnel syndrome, gait disorders, or cardiac hypertrophy. Diagnosis should include DNA testing, biopsy, and amyloid typing. Patients should be followed up every 6–12 months, depending on the severity of the disease and response to therapy. This review outlines detailed recommendations to improve the diagnosis of ATTR amyloidosis with PN.

Matching Content Categories {📚}

  • Health & Fitness
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  • Science

Content Management System {📝}

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Custom-built

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Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

pubmed, amyloidosis, google, scholar, amyloid, polyneuropathy, cas, disease, transthyretin, familial, patients, neuropathy, diagnosis, attrv, adams, cardiac, attr, ttr, biopsy, hereditary, clinical, central, neurol, dysfunction, table, autonomic, ando, symptoms, onset, early, suhr, manifestations, coelho, areas, diagnostic, family, involvement, valmet, nerve, recommendations, merlini, heart, history, peripheral, review, gene, loss, include, type, research,

Topics {✒️}

nt-probnp n-terminal fragment immune-mediated peripheral neuropathies length-dependent small-fiber pn heart [n-terminal fragment hereditary transthyretin-related amyloidosis transthyretin-related hereditary amyloidosis article download pdf idiopathic axonal polyneuropathy transthyretin mis-sense mutation université paris-saclay aphp congo red-stained preparations emerging disease-modifying therapies ttr-related amyloid neuropathy full size table idiopathic progressive neuropathy transthyretin amyloid neuropathies pubmed central sensory motor neuropathy progressive myocardial infiltration mini-invasive biopsy reduced motor skills sensory-motor dysfunction full-length ttr joão melo beirão length-dependent polyneuropathy identifying amyloid neuropathy late-onset attr amyloidosis van rijswijk mh privacy choices/manage cookies include sensory problems hereditary transthyretin amyloidosis van doorn pa familial amyloidotic polyneuropathies familial transthyretin amyloidosis autonomic peripheral neuropathy full access diseases familial amyloid polyneuropathy familial amyloidotic polyneuropathy include dna testing attr amyloid transthyretin peripheral nervous system treatable hereditary neuropathy amyloid fibril composition progressive idiopathic early disease-modifying therapy idiopathic neuropathy expert working group bilateral carpal tunnel abdominal fat aspiration

Questions {❓}

  • Adams D, Beaudonnet G, Adam C, Lacroix C, Theaudin M, Cauquil C, Labeyrie C (2016) Familial amyloid polyneuropathy: when does it stop to be asymptomatic and need a treatment?
  • Chance or challenge, spoilt for choice?

Schema {🗺️}

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         headline:Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy
         description:Amyloid transthyretin (ATTR) amyloidosis with polyneuropathy (PN) is a progressive, debilitating, systemic disease wherein transthyretin protein misfolds to form amyloid, which is deposited in the endoneurium. ATTR amyloidosis with PN is the most serious hereditary polyneuropathy of adult onset. It arises from a hereditary mutation in the TTR gene and may involve the heart as well as other organs. It is critical to identify and diagnose the disease earlier because treatments are available to help slow the progression of neuropathy. Early diagnosis is complicated, however, because presentation may vary and family history is not always known. Symptoms may be mistakenly attributed to other diseases such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), idiopathic axonal polyneuropathy, lumbar spinal stenosis, and, more rarely, diabetic neuropathy and AL amyloidosis. In endemic countries (e.g., Portugal, Japan, Sweden, Brazil), ATTR amyloidosis with PN should be suspected in any patient who has length-dependent small-fiber PN with autonomic dysfunction and a family history of ATTR amyloidosis, unexplained weight loss, heart rhythm disorders, vitreous opacities, or renal abnormalities. In nonendemic countries, the disease may present as idiopathic rapidly progressive sensory motor axonal neuropathy or atypical CIDP with any of the above symptoms or with bilateral carpal tunnel syndrome, gait disorders, or cardiac hypertrophy. Diagnosis should include DNA testing, biopsy, and amyloid typing. Patients should be followed up every 6–12 months, depending on the severity of the disease and response to therapy. This review outlines detailed recommendations to improve the diagnosis of ATTR amyloidosis with PN.
         datePublished:2020-01-06T00:00:00Z
         dateModified:2020-01-06T00:00:00Z
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            ATTRv
            Diagnosis
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            Peripheral neuropathy
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      headline:Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy
      description:Amyloid transthyretin (ATTR) amyloidosis with polyneuropathy (PN) is a progressive, debilitating, systemic disease wherein transthyretin protein misfolds to form amyloid, which is deposited in the endoneurium. ATTR amyloidosis with PN is the most serious hereditary polyneuropathy of adult onset. It arises from a hereditary mutation in the TTR gene and may involve the heart as well as other organs. It is critical to identify and diagnose the disease earlier because treatments are available to help slow the progression of neuropathy. Early diagnosis is complicated, however, because presentation may vary and family history is not always known. Symptoms may be mistakenly attributed to other diseases such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), idiopathic axonal polyneuropathy, lumbar spinal stenosis, and, more rarely, diabetic neuropathy and AL amyloidosis. In endemic countries (e.g., Portugal, Japan, Sweden, Brazil), ATTR amyloidosis with PN should be suspected in any patient who has length-dependent small-fiber PN with autonomic dysfunction and a family history of ATTR amyloidosis, unexplained weight loss, heart rhythm disorders, vitreous opacities, or renal abnormalities. In nonendemic countries, the disease may present as idiopathic rapidly progressive sensory motor axonal neuropathy or atypical CIDP with any of the above symptoms or with bilateral carpal tunnel syndrome, gait disorders, or cardiac hypertrophy. Diagnosis should include DNA testing, biopsy, and amyloid typing. Patients should be followed up every 6–12 months, depending on the severity of the disease and response to therapy. This review outlines detailed recommendations to improve the diagnosis of ATTR amyloidosis with PN.
      datePublished:2020-01-06T00:00:00Z
      dateModified:2020-01-06T00:00:00Z
      pageStart:2109
      pageEnd:2122
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         ATTR amyloidosis
         ATTRv
         Diagnosis
         hATTR
         Peripheral neuropathy
         Transthyretin amyloidosis
         Neurology
         Neurosciences
         Neuroradiology
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                  address:
                     name:Department of Neurology, French National Reference Centre for Familial Amyloidotic Polyneuropathy, CHU Bicêtre, Université Paris-Saclay APHP, INSERM U1195, Le Kremlin-Bicêtre, France
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               name:Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
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      name:Giampaolo Merlini
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            name:IRCCS Policlinico San Matteo
            address:
               name:Amyloidosis Center Foundation, IRCCS Policlinico San Matteo, San Matteo, Italy
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            name:University of Pavia
            address:
               name:Department of Molecular Medicine, University of Pavia, Pavia, Italy
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      name:Department of Neurology, French National Reference Centre for Familial Amyloidotic Polyneuropathy, CHU Bicêtre, Université Paris-Saclay APHP, INSERM U1195, Le Kremlin-Bicêtre, France
      name:Department of Neurology, Graduate School of Medical Sciences, Kumamoto, Japan
      name:Ophthalmology Service, Hospital de Santo António, Porto, Portugal
      name:Centro Hospitalar Do Porto, Porto, Portugal
      name:Mayo Clinic, Rochester, USA
      name:National Amyloidosis Centre, University College London, London, UK
      name:National Amyloidosis Centre, University College London, London, UK
      name:Amyloidosis Research Consortium, Boston, USA
      name:Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
      name:Amyloidosis Center Foundation, IRCCS Policlinico San Matteo, San Matteo, Italy
      name:Department of Molecular Medicine, University of Pavia, Pavia, Italy

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