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We began analyzing https://link.springer.com/article/10.1007/s00401-014-1349-0, but it redirected us to https://link.springer.com/article/10.1007/s00401-014-1349-0. The analysis below is for the second page.

Title[redir]:
Primary age-related tauopathy (PART): a common pathology associated with human aging | Acta Neuropathologica
Description:
We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer’s disease (AD), in the absence of amyloid (Aβ) plaques. For these “NFT+/Aβ−” brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as “tangle-only dementia” and “tangle-predominant senile dementia”, are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.

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  • Education
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Content Management System {📝}

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Custom-built

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🏙️ Massive Traffic: 50M - 100M visitors per month


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We see no obvious way the site makes money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, google, scholar, cas, disease, alzheimers, neuropathol, pathology, dementia, neurol, neurofibrillary, central, usa, alzheimer, university, aging, acta, tau, department, neuropathology, senile, brain, tangles, neurobiol, cognitive, neurology, study, braak, exp, research, dois, jellinger, impairment, elderly, center, neuropathologic, tangle, patients, institute, article, tauopathy, cortex, mild, neuropathological, dis, arch, part, hof, brains, normal,

Topics {✒️}

month download article/chapter jack cr jr �primary age-related tauopathy” primary age-related tauopathy amyloid-beta peptide aggregation tau-based therapeutic approaches specifically identified pre-mortem alzheimer-related cortical destruction amyotrophic lateral sclerosis community-based autopsy series neurofibrillary tangle-predominant dementia temporal lobe atrophy medial temporal lobe late-onset amnestic dementias full article pdf frontotemporal lobar degeneration-tau guam parkinsonism-dementia complex �tangle-predominant senile dementia” privacy choices/manage cookies posterior cortical atrophy ismael santa-maria mild cognitive impairment hauw jj parkinsonism–dementia complex tangle predominant form medical research council author information authors disease-related lesions tau imaging neurofibrillary tangle densities vascular cognitive impairment human limbic system van hoesen gw van leeuwen fw transgenic mouse brain hippocampal amyloid-beta disease-related neurofibrillary va medical center middle-aged subjects harvard medical school genetic risk factors progressive supranuclear palsy paired helical filaments tangle-predominant dementia sanders-brown center elderly nondemented subjects neurofibrillary tangle type cortical visual pathways dunhill medical trust mckeel dw jr

Questions {❓}

  • A precocious onset?
  • Bancher C, Paulus W, Paukner K, Jellinger K (1997) Neuropathologic diagnosis of Alzheimer disease: consensus between practicing neuropathologists?
  • Braak H, Del Tredici K (2012) Where, when, and in what form does sporadic Alzheimer’s disease begin?
  • Josephs KA, Whitwell JL, Parisi JE et al (2008) Argyrophilic grains: a distinct disease or an additive pathology?
  • Simic G, Stanic G, Mladinov M et al (2009) Does Alzheimer’s disease begin in the brainstem?

Schema {🗺️}

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         headline:Primary age-related tauopathy (PART): a common pathology associated with human aging
         description:We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer’s disease (AD), in the absence of amyloid (Aβ) plaques. For these “NFT+/Aβ−” brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as “tangle-only dementia” and “tangle-predominant senile dementia”, are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
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      headline:Primary age-related tauopathy (PART): a common pathology associated with human aging
      description:We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer’s disease (AD), in the absence of amyloid (Aβ) plaques. For these “NFT+/Aβ−” brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as “tangle-only dementia” and “tangle-predominant senile dementia”, are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
      datePublished:2014-10-28T00:00:00Z
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         TOD
         Braak
         Neuropathology
         Consensus
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         Neurosciences
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                  name:Columbia University Medical Center
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            name:Peter T. Nelson
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            name:University of British Columbia
            address:
               name:Department of Pathology, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Eliezer Masliah
      affiliation:
            name:University of California
            address:
               name:Departments of Neurosciences and Pathology, University of California, San Diego, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Ann McKee
      affiliation:
            name:Boston University
            address:
               name:Department of Pathology (Neuropathology), Boston University, Boston, USA
               type:PostalAddress
            type:Organization
      name:Thomas J. Montine
      affiliation:
            name:University of Washington
            address:
               name:Department of Pathology, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
      name:Melissa E. Murray
      affiliation:
            name:Mayo Clinic
            address:
               name:Department of Neuroscience, Mayo Clinic, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Janna H. Neltner
      affiliation:
            name:University of Kentucky
            address:
               name:Department of Pathology, University of Kentucky, Lexington, USA
               type:PostalAddress
            type:Organization
      name:Ismael Santa-Maria
      affiliation:
            name:Columbia University Medical Center
            address:
               name:Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
      name:William W. Seeley
      affiliation:
            name:University of California
            address:
               name:Departments of Neurology and Pathology, University of California, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Alberto Serrano-Pozo
      affiliation:
            name:University of Iowa Hospitals and Clinics
            address:
               name:Department of Neurology, University of Iowa Hospitals and Clinics, Iowa city, USA
               type:PostalAddress
            type:Organization
      name:Michael L. Shelanski
      affiliation:
            name:Columbia University Medical Center
            address:
               name:Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Thor Stein
      affiliation:
            name:VA Medical Center and Boston University School of Medicine
            address:
               name:Department of Pathology (Neuropathology), VA Medical Center and Boston University School of Medicine, Boston, USA
               type:PostalAddress
            type:Organization
      name:Masaki Takao
      affiliation:
            name:Tokyo Metropolitan Geriatric Hospital
            address:
               name:Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Dietmar R. Thal
      affiliation:
            name:University of Ulm
            address:
               name:Laboratory of Neuropathology, University of Ulm, Ulm, Germany
               type:PostalAddress
            type:Organization
      name:Jonathan B. Toledo
      affiliation:
            name:University of Pennsylvania
            address:
               name:Department of Pathology, Division of Neuropathology, University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Juan C. Troncoso
      affiliation:
            name:Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine
            address:
               name:Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Jean Paul Vonsattel
      affiliation:
            name:Columbia University Medical Center
            address:
               name:Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Charles L. White
      affiliation:
            name:University of Texas Southwestern Medical School
            address:
               name:Department of Pathology (Neuropathology), University of Texas Southwestern Medical School, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Thomas Wisniewski
      affiliation:
            name:New York University School of Medicine
            address:
               name:Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Randall L. Woltjer
      affiliation:
            name:Oregon Health Sciences University
            address:
               name:Department of Pathology L113, Oregon Health Sciences University, Portland, USA
               type:PostalAddress
            type:Organization
      name:Masahito Yamada
      affiliation:
            name:Kanazawa University Graduate School of Medical Sciences
            address:
               name:Departments of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
               type:PostalAddress
            type:Organization
      name:Peter T. Nelson
      affiliation:
            name:University of Kentucky
            address:
               name:Department of Pathology (Neuropathology) and Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, USA
      name:Department of Pathology, Division of Neuropathology, University of Pennsylvania, Philadelphia, USA
      name:Departments of Pathology (Neuropathology) and Neurological Sciences, Rush University Medical Center, Chicago, USA
      name:Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
      name:Department of Public Health and Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
      name:Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
      name:Departments of Psychiatry and Neurology, University of Pennsylvania, Philadelphia, USA
      name:Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
      name:Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, USA
      name:Department of Pathology (Neuropathology), Northwestern Cognitive Neurology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, USA
      name:Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, USA
      name:Department of Neuroscience, Mayo Clinic, Jacksonville, USA
      name:Department of Pathology and Laboratory Medicine (Neuropathology), Emory University School of Medicine, Atlanta, USA
      name:Departments of Neurology and Pathology, UC, San Francisco, USA
      name:Department of Pathology, University of Sao Paulo, Sao Paulo, Brazil
      name:Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA
      name:Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Charlestown, USA
      name:Institute of Clinical Neurobiology, Vienna, Austria
      name:Department of Neurology and the Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
      name:Institute of Neurology, Medical University Vienna, Vienna, Austria
      name:Department of Neurology, Mayo Clinic, Rochester, USA
      name:Department of Pathology (Neuropathology), University of Pittsburgh Medical Center, Pittsburgh, USA
      name:Department of Epidemiology, University of Washington, Seattle, USA
      name:Department of Pathology, University of British Columbia, Vancouver, Canada
      name:Departments of Neurosciences and Pathology, University of California, San Diego, La Jolla, USA
      name:Department of Pathology (Neuropathology), Boston University, Boston, USA
      name:Department of Pathology, University of Washington, Seattle, USA
      name:Department of Neuroscience, Mayo Clinic, Jacksonville, USA
      name:Department of Pathology, University of Kentucky, Lexington, USA
      name:Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, USA
      name:Departments of Neurology and Pathology, University of California, San Francisco, USA
      name:Department of Neurology, University of Iowa Hospitals and Clinics, Iowa city, USA
      name:Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, USA
      name:Department of Pathology (Neuropathology), VA Medical Center and Boston University School of Medicine, Boston, USA
      name:Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
      name:Laboratory of Neuropathology, University of Ulm, Ulm, Germany
      name:Department of Pathology, Division of Neuropathology, University of Pennsylvania, Philadelphia, USA
      name:Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA
      name:Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, USA
      name:Department of Pathology (Neuropathology), University of Texas Southwestern Medical School, Dallas, USA
      name:Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, New York, USA
      name:Department of Pathology L113, Oregon Health Sciences University, Portland, USA
      name:Departments of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
      name:Department of Pathology (Neuropathology) and Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
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