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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
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We began analyzing https://link.springer.com/article/10.1007/s00401-012-1047-8, but it redirected us to https://link.springer.com/article/10.1007/s00401-012-1047-8. The analysis below is for the second page.

Title[redir]:
Amyloid plaque formation precedes dendritic spine loss | Acta Neuropathologica
Description:
Amyloid-beta plaque deposition represents a major neuropathological hallmark of Alzheimer’s disease. While numerous studies have described dendritic spine loss in proximity to plaques, much less is known about the kinetics of these processes. In particular, the question as to whether synapse loss precedes or follows plaque formation remains unanswered. To address this question, and to learn more about the underlying kinetics, we simultaneously imaged amyloid plaque deposition and dendritic spine loss by applying two-photon in vivo microscopy through a cranial window in double transgenic APPPS1 mice. As a result, we first observed that the rate of dendritic spine loss in proximity to plaques is the same in both young and aged animals. However, plaque size only increased significantly in the young cohort, indicating that spine loss persists even many months after initial plaque appearance. Tracking the fate of individual spines revealed that net spine loss is caused by increased spine elimination, with the rate of spine formation remaining constant. Imaging of dendritic spines before and during plaque formation demonstrated that spine loss around plaques commences at least 4 weeks after initial plaque formation. In conclusion, spine loss occurs, shortly but with a significant time delay, after the birth of new plaques, and persists in the vicinity of amyloid plaques over many months. These findings hence give further hope to the possibility that there is a therapeutic window between initial amyloid plaque deposition and the onset of structural damage at spines.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

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Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {💸}

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While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

spine, plaques, spines, plaque, dendritic, article, google, scholar, amyloid, mice, cas, pubmed, loss, disease, months, alzheimers, fig, density, age, time, test, kinetics, formation, imaging, growth, dendrites, model, mouse, control, neurosci, dendrite, vivo, weeks, significant, lost, vicinity, pathology, transgenic, synaptic, size, twophoton, germany, anova, elimination, brain, image, tukeykramer, post, hoc, analysis,

Topics {✒️}

avoid laser-induced phototoxicity article download pdf synapse loss precedes synapse-related protein synaptophysin experience-dependent synaptic plasticity wilcoxon signed-rank test toxic amyloid-β species multicolor time-stamp reveals large dense-core vesicles open-skull cranial window β-amyloid plaque deposition abeta42-driven cerebral amyloidosis open access spires-jones tl search search translational brain research clinical brain research direct optical access β-amyloid plaque appearance maximum intensity projected wild-type control animals single time-point analysis full size image privacy choices/manage cookies plaque formation demonstrated related subjects microglial/amyloid interaction full access scheff sw dzne-german center single transgenic yfp wegenast-braun bm original author amyloid plaque formation maximum intensity projections age-matched control animals initial plaque formation fibrillar amyloid deposits filament tracer module dendritic spine formation amyloid plaque size dendritic spine loss german federal ministry amyloid plaque load amyloid plaque staining cerebral β-amyloidosis amyloid-beta plaques neurofibrillary tangle formation spine loss occurs imaging abeta plaques

Questions {❓}

  • Fiala JC, Spacek J, Harris KM (2002) Dendritic spine pathology: cause or consequence of neurological disorders?
  • We were especially interested in the chronology: Which event comes first, dendritic spine loss or plaque formation?

Schema {🗺️}

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         headline:Amyloid plaque formation precedes dendritic spine loss
         description:Amyloid-beta plaque deposition represents a major neuropathological hallmark of Alzheimer’s disease. While numerous studies have described dendritic spine loss in proximity to plaques, much less is known about the kinetics of these processes. In particular, the question as to whether synapse loss precedes or follows plaque formation remains unanswered. To address this question, and to learn more about the underlying kinetics, we simultaneously imaged amyloid plaque deposition and dendritic spine loss by applying two-photon in vivo microscopy through a cranial window in double transgenic APPPS1 mice. As a result, we first observed that the rate of dendritic spine loss in proximity to plaques is the same in both young and aged animals. However, plaque size only increased significantly in the young cohort, indicating that spine loss persists even many months after initial plaque appearance. Tracking the fate of individual spines revealed that net spine loss is caused by increased spine elimination, with the rate of spine formation remaining constant. Imaging of dendritic spines before and during plaque formation demonstrated that spine loss around plaques commences at least 4 weeks after initial plaque formation. In conclusion, spine loss occurs, shortly but with a significant time delay, after the birth of new plaques, and persists in the vicinity of amyloid plaques over many months. These findings hence give further hope to the possibility that there is a therapeutic window between initial amyloid plaque deposition and the onset of structural damage at spines.
         datePublished:2012-09-21T00:00:00Z
         dateModified:2012-09-21T00:00:00Z
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            Dendritic spines
            Amyloid plaque
            Kinetics
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            Neurosciences
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      headline:Amyloid plaque formation precedes dendritic spine loss
      description:Amyloid-beta plaque deposition represents a major neuropathological hallmark of Alzheimer’s disease. While numerous studies have described dendritic spine loss in proximity to plaques, much less is known about the kinetics of these processes. In particular, the question as to whether synapse loss precedes or follows plaque formation remains unanswered. To address this question, and to learn more about the underlying kinetics, we simultaneously imaged amyloid plaque deposition and dendritic spine loss by applying two-photon in vivo microscopy through a cranial window in double transgenic APPPS1 mice. As a result, we first observed that the rate of dendritic spine loss in proximity to plaques is the same in both young and aged animals. However, plaque size only increased significantly in the young cohort, indicating that spine loss persists even many months after initial plaque appearance. Tracking the fate of individual spines revealed that net spine loss is caused by increased spine elimination, with the rate of spine formation remaining constant. Imaging of dendritic spines before and during plaque formation demonstrated that spine loss around plaques commences at least 4 weeks after initial plaque formation. In conclusion, spine loss occurs, shortly but with a significant time delay, after the birth of new plaques, and persists in the vicinity of amyloid plaques over many months. These findings hence give further hope to the possibility that there is a therapeutic window between initial amyloid plaque deposition and the onset of structural damage at spines.
      datePublished:2012-09-21T00:00:00Z
      dateModified:2012-09-21T00:00:00Z
      pageStart:797
      pageEnd:807
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      keywords:
         Alzheimer’s disease
         Two-photon in vivo imaging
         Dendritic spines
         Amyloid plaque
         Kinetics
         Structural plasticity
         Pathology
         Neurosciences
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               type:PostalAddress
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      name:Hans Kretzschmar
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            name:Ludwig-Maximilians-University
            address:
               name:Department of Translational Brain Research, DZNE-German Center for Neurodegenerative Diseases, Munich, Ludwig-Maximilians-University, Munich, Germany
               type:PostalAddress
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PostalAddress:
      name:Center for Neuropathology, Ludwig-Maximilians University, Munich, Germany
      name:Center for Neuropathology, Ludwig-Maximilians University, Munich, Germany
      name:Department of Translational Brain Research, DZNE-German Center for Neurodegenerative Diseases, Munich, Ludwig-Maximilians-University, Munich, Germany
      name:Center for Neuropathology, Ludwig-Maximilians University, Munich, Germany
      name:Department of Translational Brain Research, DZNE-German Center for Neurodegenerative Diseases, Munich, Ludwig-Maximilians-University, Munich, Germany
      name:DZNE-German Center for Neurodegenerative Diseases, Bonn, Bonn, Germany
      name:Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
      name:DZNE-German Center for Neurodegenerative Diseases, Tübingen, Tübingen, Germany
      name:Clemens Schoepf-Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany
      name:Center for Neuropathology, Ludwig-Maximilians University, Munich, Germany
      name:Department of Translational Brain Research, DZNE-German Center for Neurodegenerative Diseases, Munich, Ludwig-Maximilians-University, Munich, Germany

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