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Title[redir]:
Die neoadjuvante Immunchemotherapie des nichtkleinzelligen Lungenkarzinoms: Was Thoraxchirurginnen und -chirurgen wissen mĂŒssen | Zeitschrift fĂŒr Herz-,Thorax- und GefĂ€Ăchirurgie
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Die neoadjuvante Immuntherapie bietet ein vielversprechendes Behandlungsverfahren des nichtkleinzelligen Lungenkarzinoms (NSCLC), dessen Prognose in der Vergangenheit trotz enormer Anstrengungen nicht wesentlich verbessert werden konnte. Nun geben (Immunâ)Checkpoint-Inhibitoren Anlass zur Hoffnung. Nun kam es 2022 zur ersten Zulassung durch die EMA, sodass einige Patientinnen und Patienten mit NSCLC bereits auĂerhalb klinischer Studien eine neoadjuvante Therapie im Kontext einer multimodalen Behandlung erhalten können. Die Ergebnisse anderer Studien werden mit Spannung erwartet. In der Zwischenzeit werden klinisch relevante Aspekte der Immuntherapie im klinischen Alltag immer prĂ€senter. Nebenwirkungen der neoadjuvanten Therapie wie beispielswiese Pneumonie, Thyreoiditis oder Kolitis können zu einer Verzögerung der onkologischen Behandlung fĂŒhren. Weiterhin bleibt die Indikationsstellung im Spannungsfeld zwischen kompletter pathologischer Remission und primĂ€rer Resistenz eine Herausforderung, mit der wir uns vermehrt auseinandersetzen werden mĂŒssen, und die uns Kenntnisse ĂŒber Besonderheiten der neoadjuvanten Immuntherapie abverlangt. Die LektĂŒre dieser Publikation ermöglicht der chirurgisch tĂ€tigen Leserschaft ein ĂŒber die unmittelbar perioperative Episode hinausreichendes klinisch relevantes VerstĂ€ndnis der Möglichkeiten und Grenzen der Immuntherapie des NSCLC.
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pubmed, article, cancer, google, scholar, lung, neoadjuvant, cas, cell, nonsmall, central, immunotherapy, nsclc, oncol, med, resectable, nonsmallcell, httpsdoiorgs, checkpoint, clin, immune, inhibitors, lungenkarzinoms, treatment, surgical, therapy, chemotherapy, thorac, nivolumab, privacy, cookies, content, neoadjuvante, nichtkleinzelligen, dörrjerat, immuntherapie, therapie, perioperative, patients, review, engl, httpsdoiorgnejmoa, nat, information, publish, search, möller, schĂŒtte, studien, clinical,
Topics {âïž}
niels michael dörr-jerat gov/protocoldevelopment/electronic_applications/docs/ctcae_v5_quick_reference_5x7 krankenhaus martha-maria halle-dölau month download article/chapter related subjects perioperative episode immune-related adverse events treatment-related adverse events article dörr-jerat immune checkpoint inhibitors small-cell lung cancer complete pathological remission schĂŒtte und randomized phase iii study macroscopic stage iii melanoma full article pdf thoracic surgeons neoadjuvant checkpoint blockade scagliotti gv chaft je receive neoadjuvant treatment privacy choices/manage cookies resectable nsclc checkpoint inhibitors dörr-jerat neoadjuvant chemo-immunotherapy response evaluation criteria 1038/s41591-023-02627-7 cascone neoadjuvant pdâ1 blockade single-arm study neoadjuvant pdâ1 inhibitor resectable lung cancer revisiting neoadjuvant therapy article log everyday clinical practice check access ethics declarations interessenkonflikt instant access nsclc article cite european economic area european medicines agency pseudoprogression remain challenging clinically relevant understanding lace collaborative group tissue resident memory perioperative pembrolizumab 1056/nejmoa2302983 heymach jv perioperative durvalumab perioperative toripalimab
Questions {â}
- Li F, Chen Y, Wu J et al (2022) The earlier, the better?
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headline:Die neoadjuvante Immunchemotherapie des nichtkleinzelligen Lungenkarzinoms: Was Thoraxchirurginnen und -chirurgen wissen mĂŒssen
description:Die neoadjuvante Immuntherapie bietet ein vielversprechendes Behandlungsverfahren des nichtkleinzelligen Lungenkarzinoms (NSCLC), dessen Prognose in der Vergangenheit trotz enormer Anstrengungen nicht wesentlich verbessert werden konnte. Nun geben (Immunâ)Checkpoint-Inhibitoren Anlass zur Hoffnung. Nun kam es 2022 zur ersten Zulassung durch die EMA, sodass einige Patientinnen und Patienten mit NSCLC bereits auĂerhalb klinischer Studien eine neoadjuvante Therapie im Kontext einer multimodalen Behandlung erhalten können. Die Ergebnisse anderer Studien werden mit Spannung erwartet. In der Zwischenzeit werden klinisch relevante Aspekte der Immuntherapie im klinischen Alltag immer prĂ€senter. Nebenwirkungen der neoadjuvanten Therapie wie beispielswiese Pneumonie, Thyreoiditis oder Kolitis können zu einer Verzögerung der onkologischen Behandlung fĂŒhren. Weiterhin bleibt die Indikationsstellung im Spannungsfeld zwischen kompletter pathologischer Remission und primĂ€rer Resistenz eine Herausforderung, mit der wir uns vermehrt auseinandersetzen werden mĂŒssen, und die uns Kenntnisse ĂŒber Besonderheiten der neoadjuvanten Immuntherapie abverlangt. Die LektĂŒre dieser Publikation ermöglicht der chirurgisch tĂ€tigen Leserschaft ein ĂŒber die unmittelbar perioperative Episode hinausreichendes klinisch relevantes VerstĂ€ndnis der Möglichkeiten und Grenzen der Immuntherapie des NSCLC.
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description:Die neoadjuvante Immuntherapie bietet ein vielversprechendes Behandlungsverfahren des nichtkleinzelligen Lungenkarzinoms (NSCLC), dessen Prognose in der Vergangenheit trotz enormer Anstrengungen nicht wesentlich verbessert werden konnte. Nun geben (Immunâ)Checkpoint-Inhibitoren Anlass zur Hoffnung. Nun kam es 2022 zur ersten Zulassung durch die EMA, sodass einige Patientinnen und Patienten mit NSCLC bereits auĂerhalb klinischer Studien eine neoadjuvante Therapie im Kontext einer multimodalen Behandlung erhalten können. Die Ergebnisse anderer Studien werden mit Spannung erwartet. In der Zwischenzeit werden klinisch relevante Aspekte der Immuntherapie im klinischen Alltag immer prĂ€senter. Nebenwirkungen der neoadjuvanten Therapie wie beispielswiese Pneumonie, Thyreoiditis oder Kolitis können zu einer Verzögerung der onkologischen Behandlung fĂŒhren. Weiterhin bleibt die Indikationsstellung im Spannungsfeld zwischen kompletter pathologischer Remission und primĂ€rer Resistenz eine Herausforderung, mit der wir uns vermehrt auseinandersetzen werden mĂŒssen, und die uns Kenntnisse ĂŒber Besonderheiten der neoadjuvanten Immuntherapie abverlangt. Die LektĂŒre dieser Publikation ermöglicht der chirurgisch tĂ€tigen Leserschaft ein ĂŒber die unmittelbar perioperative Episode hinausreichendes klinisch relevantes VerstĂ€ndnis der Möglichkeiten und Grenzen der Immuntherapie des NSCLC.
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