DOI . ORG {
}
We began analyzing https://link.springer.com/article/10.1007/s00395-008-0733-0, but it redirected us to https://link.springer.com/article/10.1007/s00395-008-0733-0. The analysis below is for the second page.
Title[redir]:
The role of inflammatory cytokines in endothelial dysfunction | Basic Research in Cardiology
Description:
Clinical and experimental data support a link between endothelial dysfunction and inflammation. Inflammatory cytokines are important protagonists in formation of atherosclerotic plaque, eliciting effects throughout the atherosclerotic vessel. Importantly, the development of atherosclerotic lesions, regardless of the risk factor, e.g., diabetes, hypertension, obesity, is characterized by disruption in normal function of the endothelial cells. Endothelial cells, which line the internal lumen of the vasculature, are part of a complex system that regulates vasodilation and vasoconstriction, growth of vascular smooth muscle cells, inflammation, and hemostasis, maintaining a proper blood supply to tissues and regulating inflammation and coagulation. Current concepts suggest that the earliest event in atherogenesis is endothelial dysfunction, manifested by deficiencies in the production of nitric oxide (NO) and prostacyclin. The focus of this review is to summarize recent evidence showing the effects of inflammation on vascular dysfunction in ischemic-heart disease, which may prompt new directions for targeting inflammation in future therapies.
Title[redir]:
The role of inflammatory cytokines in endothelial dysfunction | Basic Research in Cardiology
Description:
Clinical and experimental data support a link between endothelial dysfunction and inflammation. Inflammatory cytokines are important protagonists in formation of atherosclerotic plaque, eliciting effects throughout the atherosclerotic vessel. Importantly, the development of atherosclerotic lesions, regardless of the risk factor, e.g., diabetes, hypertension, obesity, is characterized by disruption in normal function of the endothelial cells. Endothelial cells, which line the internal lumen of the vasculature, are part of a complex system that regulates vasodilation and vasoconstriction, growth of vascular smooth muscle cells, inflammation, and hemostasis, maintaining a proper blood supply to tissues and regulating inflammation and coagulation. Current concepts suggest that the earliest event in atherogenesis is endothelial dysfunction, manifested by deficiencies in the production of nitric oxide (NO) and prostacyclin. The focus of this review is to summarize recent evidence showing the effects of inflammation on vascular dysfunction in ischemic-heart disease, which may prompt new directions for targeting inflammation in future therapies.
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Keywords {๐}
google, scholar, pubmed, article, cas, endothelial, res, dysfunction, vascular, cells, cell, basic, role, circ, tumor, necrosis, zhang, inflammation, expression, heart, cardiol, oxidase, physiol, biol, diabetes, nitric, factor, oxide, human, coronary, tnfalpha, superoxide, cytokines, production, circulation, activation, function, research, effects, disease, heusch, schulz, injury, factoralpha, mol, arterioscler, thromb, vasc, nadph, products,
Topics {โ๏ธ}
month download article/chapter tnf-alpha induces interleukin-8 tumor necrosis factor-alpha tumor necrosis factor-{alpha} tnf-ฮฑ-induced impairment stz-induced diabetic rats transcription factor nf-kappa tnf-alpha potentiates oxidant nf-kappab induced tnf-induced oxidative stress angiotensin ii-mediated hypertension ischemic-heart disease nuclear factor-kappa tnf-alpha-dependent expression article basic research chronic vascular inflammation tumor necrosis factor tumor-necrosis factor cardiac ischemia-reperfusion injury superoxide-generating nadh/nad human diabetes mellitus tnf-alpha contributes full article pdf flow-mediated dilation tnf-alpha antibodies chronic heart failure cuihua zhang md vascular superoxide production de almeida jr vascular cell function endothelium-dependent vasodilation human endothelial cells vascular endothelial cells privacy choices/manage cookies coronary heart disease nitric oxide nf-kappab alcohol-induced defect specific nf-kappa stress-activated protein kinase reactive oxygen species endothelial cell activation free radical production advanced heart failure van de sand ushio-fukai oxygen free radicals endothelial cells exposed microvascular endothelial cells superoxide generation
Questions {โ}
- Garcia SC, Pomblum V, Gams E, Langenbach MR, Schipke JD (2007) Independency of myocardial stunning of endothelial stunning?
- Stenvinkel P (2001) Endothelial dysfunction and inflammationโis there a link?
- Yudkin GS, Stehouwer CD, Emeis JJEA (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?
Schema {๐บ๏ธ}
WebPage:
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headline:The role of inflammatory cytokines in endothelial dysfunction
description:Clinical and experimental data support a link between endothelial dysfunction and inflammation. Inflammatory cytokines are important protagonists in formation of atherosclerotic plaque, eliciting effects throughout the atherosclerotic vessel. Importantly, the development of atherosclerotic lesions, regardless of the risk factor, e.g., diabetes, hypertension, obesity, is characterized by disruption in normal function of the endothelial cells. Endothelial cells, which line the internal lumen of the vasculature, are part of a complex system that regulates vasodilation and vasoconstriction, growth of vascular smooth muscle cells, inflammation, and hemostasis, maintaining a proper blood supply to tissues and regulating inflammation and coagulation. Current concepts suggest that the earliest event in atherogenesis is endothelial dysfunction, manifested by deficiencies in the production of nitric oxide (NO) and prostacyclin. The focus of this review is to summarize recent evidence showing the effects of inflammation on vascular dysfunction in ischemic-heart disease, which may prompt new directions for targeting inflammation in future therapies.
datePublished:2008-07-03T00:00:00Z
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headline:The role of inflammatory cytokines in endothelial dysfunction
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vascular dysfunction
cytokines
ischemic-heart disease
nitric oxide
vasodilation
Cardiology
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