DOI . ORG {
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Title[redir]:
Amyloid plaque imaging in vivo: current achievement and future prospects | European Journal of Nuclear Medicine and Molecular Imaging
Description:
Introduction Alzheimer’s disease (AD) is a very complex neurodegenerative disorder, the exact cause of which is still not known. The major histopathological features, amyloid plaques and neurofibrillary tangles, already described by Alois Alzheimer, have been the focus in research for decades. Despite a probable whole cascade of events in the brain leading to impairment of cognition, amyloid is still the target for diagnosis and treatment. Discussion The rapid development of molecular imaging techniques now allows imaging of amyloid plaques in vivo in Alzheimer patients by PET amyloid ligands such as Pittsburgh compound B (PIB). Studies so far have revealed high 11C-PIB retention in brain at prodromal stages of AD and a possibility to discriminate AD from other dementia disorders by 11C-PIB. Ongoing studies are focussing to understand the relationship between brain and CSF amyloid processes and cognitive processes. Conclusion In vivo imaging of amyloid will be important for early diagnosis and evaluation of new anti-amyloid therapies in AD.
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article, google, scholar, disease, imaging, amyloid, pubmed, alzheimers, cas, brain, pet, alzheimer, dementia, neurology, plaques, patients, neurol, vivo, nordberg, cpib, ann, binding, pittsburgh, cognitive, med, positron, emission, tomography, press, privacy, cookies, content, journal, research, access, nucl, βamyloid, publish, search, molecular, plaque, agneta, impairment, pib, burden, aging, abeta, kepe, klunk, engler,
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ec-fp5-project nci-mci month download article/chapter radiofluorinated 6-dialkylamino-2-naphtylethylidene derivatives dialkylamino-6-acylmalonnonitrile substituted naphthalenes 11c-pib pet imaging positron emission tomography beta-amyloid peptide fibrils imaging β-amyloid burden molecular imaging aims molecular imaging techniques article european journal amyloid plaque imaging full article pdf [11c]-pib imaging privacy choices/manage cookies related subjects nucl mol imaging [11c]sb-13 pet β-amyloid imaging swedish research council mol imaging biol alzheimer disease beta-amyloid european economic area amyloid-β peptide pet amyloid ligands alzheimer-related lesions potentional antecendent marker β-amyloid probe article nordberg beta-amyloid plaques a-beta deposition β-amyloid plaques β-amyloid burden imaging brain amyloid anti-amyloid therapies complex neurodegenerative disorder major histopathological features 2-[2-dimethylaminothiazol-5-yl] ethenyl transgenic mouse model parkinsonism relat disord novum 5th floor vivo amyloid imaging dense amyloid plaques conditions privacy policy csf amyloid processes cerebral amyloid angiopathy living mouse model voxel-based analysis frontotemporal lobar degeneration cerebral glucose metabolism
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headline:Amyloid plaque imaging in vivo: current achievement and future prospects
description:Alzheimer’s disease (AD) is a very complex neurodegenerative disorder, the exact cause of which is still not known. The major histopathological features, amyloid plaques and neurofibrillary tangles, already described by Alois Alzheimer, have been the focus in research for decades. Despite a probable whole cascade of events in the brain leading to impairment of cognition, amyloid is still the target for diagnosis and treatment. The rapid development of molecular imaging techniques now allows imaging of amyloid plaques in vivo in Alzheimer patients by PET amyloid ligands such as Pittsburgh compound B (PIB). Studies so far have revealed high 11C-PIB retention in brain at prodromal stages of AD and a possibility to discriminate AD from other dementia disorders by 11C-PIB. Ongoing studies are focussing to understand the relationship between brain and CSF amyloid processes and cognitive processes. In vivo imaging of amyloid will be important for early diagnosis and evaluation of new anti-amyloid therapies in AD.
datePublished:2008-01-11T00:00:00Z
dateModified:2008-01-11T00:00:00Z
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Positron emission tomography (PET)
Amyloid
PIB
Alzheimer’s disease
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Nuclear Medicine
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headline:Amyloid plaque imaging in vivo: current achievement and future prospects
description:Alzheimer’s disease (AD) is a very complex neurodegenerative disorder, the exact cause of which is still not known. The major histopathological features, amyloid plaques and neurofibrillary tangles, already described by Alois Alzheimer, have been the focus in research for decades. Despite a probable whole cascade of events in the brain leading to impairment of cognition, amyloid is still the target for diagnosis and treatment. The rapid development of molecular imaging techniques now allows imaging of amyloid plaques in vivo in Alzheimer patients by PET amyloid ligands such as Pittsburgh compound B (PIB). Studies so far have revealed high 11C-PIB retention in brain at prodromal stages of AD and a possibility to discriminate AD from other dementia disorders by 11C-PIB. Ongoing studies are focussing to understand the relationship between brain and CSF amyloid processes and cognitive processes. In vivo imaging of amyloid will be important for early diagnosis and evaluation of new anti-amyloid therapies in AD.
datePublished:2008-01-11T00:00:00Z
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PIB
Alzheimer’s disease
Diagnostic marker
Nuclear Medicine
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Cardiology
Oncology
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