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We began analyzing https://link.springer.com/article/10.1007/s00198-009-1119-3, but it redirected us to https://link.springer.com/article/10.1007/s00198-009-1119-3. The analysis below is for the second page.

Title[redir]:
Benefit–risk assessment of vitamin D supplementation | Osteoporosis International
Description:
Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D. This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk. Based on double-blind randomized control trials (RCTs), eight for falls (n = 2426) and 12 for non-vertebral fractures (n = 42,279), there was a significant dose–response relationship between higher-dose and higher achieved 25(OH)D and greater fall and fracture prevention. Optimal benefits were observed at the highest dose tested to date for 700 to 1000 IU vitamin D per day or mean 25(OH)D between 75 and 110 nmol/l (30–44 ng/ml). Prospective cohort data on cardiovascular health and colorectal cancer prevention suggested increased benefits with the highest categories of 25(OH)D evaluated (median between 75 and 110 nmol/l). In 25 RCTs, mean serum calcium levels were not related to oral vitamin D up to 100,000 IU per day or achieved 25(OH)D up to 643 nmol/l. Mean levels of 75 to 110 nmol/l were reached in most RCTs with 1,800 to 4,000 IU vitamin D per day without risk. Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.

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  • Education
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Custom-built

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🏙️ Massive Traffic: 50M - 100M visitors per month


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Keywords {🔍}

google, scholar, vitamin, pubmed, cas, supplementation, clin, calcium, nutr, serum, med, elderly, bone, women, study, levels, risk, randomized, trial, bischoffferrari, hydroxyvitamin, endocrinol, effect, effects, article, cancer, oral, intoxication, intern, metab, ohd, fractures, health, treatment, patients, int, cholecalciferol, intake, prevention, controlled, men, adults, disease, dose, prospective, older, arch, miner, res, dietary,

Topics {✒️}

month download article/chapter bischoff-ferrari ha randomised placebo-controlled trial article bischoff-ferrari benefit–risk assessment nursing home residents randomized double-blind trial placebo-controlled clinical trial bischoff-ferrari council community-dwelling older individuals bischoff-ferrari department significant dose–response relationship chronic kidney disease high-dose ergocalciferol supplementation full article pdf privacy choices/manage cookies dietary supplement-induced vitamin home-delivery dairy daily low-dose vitamin placebo-controlled trial bischoff-ferrari bischoff-ferrari  randomized controlled trials placebo-controlled study randomized controlled trial high-dose ergocalciferol colorectal cancer prevention risk assessment unrestricted grant provided increased bone resorption corticosteroid-induced osteopenia quantitative meta analysis dawson-hughes department parathyroid hormone levels provide optimal benefits randomized clinical trial cardiovascular disease mortality low-trauma fractures european economic area scope submit manuscript nutrition examination survey beta cell dysfunction anti-tumor activity negative endocrine regulator renin-angiotensin system middle-aged norwegians congestive heart failure supplements extended oral dosing graded oral dosing

Questions {❓}

  • Flicker L et al (2004) Should all older people in residential care receive vitamin D to prevent falls?
  • Meyer HE et al (2002) Can vitamin D supplementation reduce the risk of fracture in the elderly?

Schema {🗺️}

WebPage:
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         headline:Benefit–risk assessment of vitamin D supplementation
         description:Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D. This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk. Based on double-blind randomized control trials (RCTs), eight for falls (n = 2426) and 12 for non-vertebral fractures (n = 42,279), there was a significant dose–response relationship between higher-dose and higher achieved 25(OH)D and greater fall and fracture prevention. Optimal benefits were observed at the highest dose tested to date for 700 to 1000 IU vitamin D per day or mean 25(OH)D between 75 and 110 nmol/l (30–44 ng/ml). Prospective cohort data on cardiovascular health and colorectal cancer prevention suggested increased benefits with the highest categories of 25(OH)D evaluated (median between 75 and 110 nmol/l). In 25 RCTs, mean serum calcium levels were not related to oral vitamin D up to 100,000 IU per day or achieved 25(OH)D up to 643 nmol/l. Mean levels of 75 to 110 nmol/l were reached in most RCTs with 1,800 to 4,000 IU vitamin D per day without risk. Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
         datePublished:2009-12-03T00:00:00Z
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      headline:Benefit–risk assessment of vitamin D supplementation
      description:Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D. This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk. Based on double-blind randomized control trials (RCTs), eight for falls (n = 2426) and 12 for non-vertebral fractures (n = 42,279), there was a significant dose–response relationship between higher-dose and higher achieved 25(OH)D and greater fall and fracture prevention. Optimal benefits were observed at the highest dose tested to date for 700 to 1000 IU vitamin D per day or mean 25(OH)D between 75 and 110 nmol/l (30–44 ng/ml). Prospective cohort data on cardiovascular health and colorectal cancer prevention suggested increased benefits with the highest categories of 25(OH)D evaluated (median between 75 and 110 nmol/l). In 25 RCTs, mean serum calcium levels were not related to oral vitamin D up to 100,000 IU per day or achieved 25(OH)D up to 643 nmol/l. Mean levels of 75 to 110 nmol/l were reached in most RCTs with 1,800 to 4,000 IU vitamin D per day without risk. Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
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      name:Council for Responsible Nutrition, Washington, USA
      name:USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA
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      name:Department of Nutrition, Harvard School of Public Health, Boston, USA
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External Links {🔗}(436)

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