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Keywords {🔍}

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Topics {✒️}

cholera toxin genes cholera toxin structure gene regulation cholera toxin expression strong oral immunogenicity month download article/chapter cholera toxin intracellular transport multi-peptide vaccine site autoimmune privacy choices/manage cookies check access instant access full article pdf vaccine candidate generated additional perspectives european economic area scope submit manuscript remained essentially unaltered previously unsuspected condition related subjects author correspondence regulation conditions privacy policy heterologous expression system accepting optional cookies cell intoxication process article cellular journal finder publish 1007/s00018-008-7496-5 keywords article log molecular level life sci usage analysis privacy policy article sánchez personal data immunological aspects article cite books a information optional cookies manage preferences subscription content similar content data protection immunological field essential cookies cookies skip

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         description:Many notions regarding the function, structure and regulation of cholera toxin expression have remained essentially unaltered in the last 15 years. At the same time, recent findings have generated additional perspectives. For example, the cholera toxin genes are now known to be carried by a non-lytic bacteriophage, a previously unsuspected condition. Understanding of how the expression of cholera toxin genes is controlled by the bacterium at the molecular level has advanced significantly and relationships with cell-density-associated (quorum-sensing) responses have recently been discovered. Regarding the cell intoxication process, the mode of entry and intracellular transport of cholera toxin are becoming clearer. In the immunological field, the strong oral immunogenicity of the non-toxic B subunit of cholera toxin (CTB) has been exploited in the development of a now widely licensed oral cholera vaccine. Additionally, CTB has been shown to induce tolerance against co-administered (linked) foreign antigens in some autoimmune and allergic diseases.
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      headline:Cholera toxin structure, gene regulation and pathophysiological and immunological aspects
      description:Many notions regarding the function, structure and regulation of cholera toxin expression have remained essentially unaltered in the last 15 years. At the same time, recent findings have generated additional perspectives. For example, the cholera toxin genes are now known to be carried by a non-lytic bacteriophage, a previously unsuspected condition. Understanding of how the expression of cholera toxin genes is controlled by the bacterium at the molecular level has advanced significantly and relationships with cell-density-associated (quorum-sensing) responses have recently been discovered. Regarding the cell intoxication process, the mode of entry and intracellular transport of cholera toxin are becoming clearer. In the immunological field, the strong oral immunogenicity of the non-toxic B subunit of cholera toxin (CTB) has been exploited in the development of a now widely licensed oral cholera vaccine. Additionally, CTB has been shown to induce tolerance against co-administered (linked) foreign antigens in some autoimmune and allergic diseases.
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