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article, jakstat, signalling, pathway, privacy, cookies, content, research, access, information, publish, search, biological, significance, knockout, data, log, journal, clinical, igaz, tóth, falus, immune, discover, springer, make, optional, personal, parties, policy, find, track, inflammation, lessons, mice, cite, explore, participate, system, institution, signaling, open, november, march, basic, chapter, related, subjects, cell, author,

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month download article/chapter jak/stat signaling pathway jak–stat signaling jak-stat pathway privacy choices/manage cookies signalling system full article pdf related subjects murine knockout models signal-transducing pathway european economic area knockout mice published scope submit manuscript conditions privacy policy accepting optional cookies journal finder publish check access instant access signalling immune mediators article log knockout mice review article privacy policy personal data article igaz books a article cite optional cookies manage preferences biological significance cell subscription content similar content data protection essential cookies cookies skip immune institution subscribe journal publish igaz department usage analysis social media varying standards clinical significance september 2001 volume 50 human diseases latest articles machine learning semmelweis university

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         headline:Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice
         description: Originally described as the signal-transducing pathway of interferons, the JAK-STAT pathway soon turned out to participate in the signalling of numerous other immune and even non-immune mediators. Several murine knockout models have been described that underline the biological significance of this signalling system. Some human diseases (mainly neoplastic) are also known where malfunctioning of the JAK-STAT pathway is considered to participate in the pathogenesis. In this brief review article we will try to make a synopsis of its biological and clinical significance.
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      headline:Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice
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