
DOI . ORG {
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Title[redir]:
Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease | Acta Neuropathologica
Description:
Acta Neuropathologica - In this report we quantitatively assess the numbers of intracellular and extracellular neurofibrillary tangles (NFT) in the brains of a series of individuals with...
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google, scholar, disease, neurofibrillary, alzheimer, perry, tangles, alzheimers, smith, usa, extracellular, protein, acad, article, neuronal, pathology, proc, natl, sci, richey, acta, cras, neuropathol, privacy, cookies, content, siedlak, nft, data, publish, search, loss, brain, access, tau, chapter, senile, cortex, springer, products, information, log, journal, research, evidence, extensive, crosslinking, patrick, mulvihill, demonstration,
Topics {βοΈ}
month download article/chapter extensive protein cross-linking anti-amyloid-beta therapy neurofibrillary tangle counts extracellular neurofibrillary tangles extensive cross-links privacy choices/manage cookies neuronal loss full article pdf paired helical filaments carbonyl-related modifications european economic area distinct mechanisms responsible 295-1-trypsin immunore-activity born-bunge foundation glycated tau protein conditions privacy policy temporal neocortex examined cerebral grey matter lamina-specific pathology article cras accepting optional cookies neurofibrillary tangles check access instant access main content log human telencephalic cortex neuronal counts journal finder publish alzheimer disease patients neuronal death neuronal antigen related subjects alzheimer disease pathology alzheimer cytoskeletal pathology mann dma alzheimer-type dementia acta neuropathol acta neuropathol 81 acta neuropathol 89 neurofibrillary pathology smith ma article log degenerating neurites protein tau privacy policy protein constituents astroglial reaction protein oxidation article cite
Questions {β}
- Perry G, Smith MA (1993) Senile plaques and neurofibrillary tangles: what role do they play in Alzheimer disease?
- Smith MA, Perry G (1994) Alzheimer disease: an imbalance of proteolytic regulation?
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headline:Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease
description:In this report we quantitatively assess the numbers of intracellular and extracellular neurofibrillary tangles (NFT) in the brains of a series of individuals with Alzheimer's disease and of controls and correlate these with neuronal loss. Our data indicate that in some cases, NFT are not removed from the brain throughout the disease process. This finding, together with our previous demonstration of carbonyl-related modifications in NFT, provides additional evidence that the protein constituents of NFT are resistant to proteolytic removal, possibly as a result of extensive cross-links. Additionally, correlation between the number of NFT and neuronal loss indicates that there are at least two distinct mechanisms responsible for neuronal death in Alzheimer's disease that are directly and indirectly related to the presence of neurofibrillary pathology.
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Protein cross-linking
Microglia
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Pathology
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description:In this report we quantitatively assess the numbers of intracellular and extracellular neurofibrillary tangles (NFT) in the brains of a series of individuals with Alzheimer's disease and of controls and correlate these with neuronal loss. Our data indicate that in some cases, NFT are not removed from the brain throughout the disease process. This finding, together with our previous demonstration of carbonyl-related modifications in NFT, provides additional evidence that the protein constituents of NFT are resistant to proteolytic removal, possibly as a result of extensive cross-links. Additionally, correlation between the number of NFT and neuronal loss indicates that there are at least two distinct mechanisms responsible for neuronal death in Alzheimer's disease that are directly and indirectly related to the presence of neurofibrillary pathology.
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