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ScholarlyArticle:
      headline:The Role of Inflammation in Skin Cancer
      pageEnd:469
      pageStart:437
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-0348-0837-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Inflammation and Cancer
         isbn:
            978-3-0348-0837-8
            978-3-0348-0836-1
         type:Book
      publisher:
         name:Springer Basel
         logo:
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            type:ImageObject
         type:Organization
      author:
            name:Girish B. Maru
            affiliation:
                  name:Tata Memorial Centre (TMC)
                  address:
                     name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Khushboo Gandhi
            affiliation:
                  name:Tata Memorial Centre (TMC)
                  address:
                     name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Asha Ramchandani
            affiliation:
                  name:Tata Memorial Centre (TMC)
                  address:
                     name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gaurav Kumar
            affiliation:
                  name:Tata Memorial Centre (TMC)
                  address:
                     name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Skin, Chronic inflammation, Causative agents, Risk factors, Skin cancer, Basal cell carcinoma, Squamous cell carcinoma, Melanoma, Molecular mechanism(s), Prevention, Treatment
      description:Cancer is an environmental disease and skin cancer (melanoma and non-melanoma) is the most common of all cancers. Epidemiological and experimental evidence suggest “chronic inflammation” to be one of the hallmarks in solar ultraviolet radiation and several other environmental agent-mediated skin cancers. The identification of transcription factors, mainly nuclear factor-kappa B (NF-κB), signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1 alpha (HIF-1α) and their gene products i.e. prostaglandins, cyclooxygenase-2 (COX-2), cytokines [tumor necrosis factor- alpha (TNF-α)], chemokines [CXC-chemokine ligand (CXCL)] and chemokine receptors suggest critical role of inflammation in skin carcinogenesis. Considering the potential role of inflammation in tumor initiation and its major role in promotion/progression, as well as tumor angiogenesis and metastasis; inflammatory pathways may become attractive targets for skin cancer prevention. Hence this review focuses on compiling available evidence and understanding the role of chronic inflammation in the development of skin cancer.
      datePublished:2014
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         name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
         type:PostalAddress
      name:Tata Memorial Centre (TMC)
      address:
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         type:PostalAddress
      name:Tata Memorial Centre (TMC)
      address:
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         type:PostalAddress
      name:Tata Memorial Centre (TMC)
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      name:Girish B. Maru
      affiliation:
            name:Tata Memorial Centre (TMC)
            address:
               name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Khushboo Gandhi
      affiliation:
            name:Tata Memorial Centre (TMC)
            address:
               name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
               type:PostalAddress
            type:Organization
      name:Asha Ramchandani
      affiliation:
            name:Tata Memorial Centre (TMC)
            address:
               name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
               type:PostalAddress
            type:Organization
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      affiliation:
            name:Tata Memorial Centre (TMC)
            address:
               name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
               type:PostalAddress
            type:Organization
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      name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
      name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
      name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
      name:Maru Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India
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