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article, google, scholar, cas, ghaffari, foxo, transcription, cell, erythroid, protocol, liang, blood, erythropoiesis, saghi, york, privacy, cookies, content, information, publish, factors, biology, factor, biol, usa, springer, search, functions, raymond, cells, maturation, access, chapter, regulation, zhang, download, icahn, school, medicine, mount, sinai, usd, essential, analysis, personal, data, log, journal, research, menon,

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ScholarlyArticle:
      headline:Following Transcriptome to Uncover FOXO Biological Functions
      pageEnd:227
      pageStart:219
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-8900-3.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:FOXO Transcription Factors
         isbn:
            978-1-4939-8900-3
            978-1-4939-8899-0
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Raymond Liang
            affiliation:
                  name:Icahn School of Medicine at Mount Sinai
                  address:
                     name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Icahn School of Medicine at Mount Sinai
                  address:
                     name:Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vijay Menon
            affiliation:
                  name:Icahn School of Medicine at Mount Sinai
                  address:
                     name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Saghi Ghaffari
            affiliation:
                  name:Icahn School of Medicine at Mount Sinai
                  address:
                     name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Icahn School of Medicine at Mount Sinai
                  address:
                     name:Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Icahn School of Medicine at Mount Sinai
                  address:
                     name:Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Icahn School of Medicine at Mount Sinai
                  address:
                     name:Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Erythropoiesis, Red blood cell (RBC), Enucleation, Mitochondria, Mitophagy, FOXO, FOXO3, Transcriptome, RNA sequencing
      description:Two and half million red blood cells (RBC) are generated every second in a healthy adult. The process of RBC production known as erythropoiesis requires a meticulous synchrony between signaling processes and the activity of many transcription factor complexes. FOXO3 is a transcription factor that is responsive to signaling processes and essential for the erythroid proliferation and maturation, RBC formation, and lifespan. Here, we discuss how using an integrated computational and experimental systems biology approach new and unanticipated FOXO3 functions in terminal erythropoiesis were uncovered. These combinatory approaches identified FOXO3 as a key regulator of terminal erythropoiesis. As a result, a new mode of FOXO3 participation in erythroid transcription complex formation has been proposed.
      datePublished:2019
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      name:FOXO Transcription Factors
      isbn:
         978-1-4939-8900-3
         978-1-4939-8899-0
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      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Icahn School of Medicine at Mount Sinai
      address:
         name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
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      name:Icahn School of Medicine at Mount Sinai
      address:
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         type:PostalAddress
      name:Icahn School of Medicine at Mount Sinai
      address:
         name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
         type:PostalAddress
      name:Icahn School of Medicine at Mount Sinai
      address:
         name:Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, USA
         type:PostalAddress
      name:Icahn School of Medicine at Mount Sinai
      address:
         name:Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, USA
         type:PostalAddress
      name:Icahn School of Medicine at Mount Sinai
      address:
         name:Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Raymond Liang
      affiliation:
            name:Icahn School of Medicine at Mount Sinai
            address:
               name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
               type:PostalAddress
            type:Organization
            name:Icahn School of Medicine at Mount Sinai
            address:
               name:Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, USA
               type:PostalAddress
            type:Organization
      name:Vijay Menon
      affiliation:
            name:Icahn School of Medicine at Mount Sinai
            address:
               name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
               type:PostalAddress
            type:Organization
      name:Saghi Ghaffari
      affiliation:
            name:Icahn School of Medicine at Mount Sinai
            address:
               name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
               type:PostalAddress
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            name:Icahn School of Medicine at Mount Sinai
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               name:Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, USA
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      name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
      name:Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA
      name:Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, USA
      name:Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, USA
      name:Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA
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