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We began analyzing https://link.springer.com/protocol/10.1007/978-1-4939-7138-1_10, but it redirected us to https://link.springer.com/protocol/10.1007/978-1-4939-7138-1_10. The analysis below is for the second page.

Title[redir]:
X-Aptamer Selection and Validation | SpringerLink
Description:
Aptamers and second generation analogs, such as X-Aptamers (XAs), SOMAmers, locked nucleic acids (LNAs), and others are increasingly being used for molecular pathway targeting, biomarker discovery, or disease diagnosis by interacting with protein targets on the...

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Keywords {🔍}

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Schema {🗺️}

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      headline:X-Aptamer Selection and Validation
      pageEnd:174
      pageStart:151
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      genre:
         Springer Protocols
      isPartOf:
         name:RNA Nanostructures
         isbn:
            978-1-4939-7138-1
            978-1-4939-7137-4
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         name:Springer New York
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            affiliation:
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                  address:
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                     type:PostalAddress
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                  name:The University of Texas Health Science Center
                  address:
                     name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongyu Wang
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                  name:The University of Texas Health Science Center
                  address:
                     name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
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                     type:PostalAddress
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                     type:PostalAddress
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                  name:The University of Texas Health Science Center
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      keywords:Aptamer, X-Aptamer, Molecular targeting, Biotin labeling, Dye labeling, Bead-based selection, Split-pool synthesis, Drug aptamer conjugation, Aptamer nanoparticle conjugation, Aptamer siRNA chimeras, Chemical cross-linking, Proteomics
      description:Aptamers and second generation analogs, such as X-Aptamers (XAs), SOMAmers, locked nucleic acids (LNAs), and others are increasingly being used for molecular pathway targeting, biomarker discovery, or disease diagnosis by interacting with protein targets on the surface of cells or in solution. Such targeting is being used for imaging, diagnostic evaluation, interference of protein function, or delivery of therapeutic agents. Selection of aptamers using the original SELEX method is cumbersome and time-consuming, often requiring 10–15 rounds of selection, and provides aptamers with a limited number of functional groups, namely four bases of DNA or RNA, although newer SELEX methods have increased this diversity. In contrast, X-Aptamers provide an unlimited number of functional groups and thus are superior targeting agents. Here, we discuss the X-Aptamer selection process.
      datePublished:2017
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      name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
      name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
      name:AM Biotechnologies, LLC, Houston, USA
      name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
      name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
      name:AM Biotechnologies, LLC, Houston, USA
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      name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
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