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We began analyzing https://link.springer.com/protocol/10.1007/978-1-4939-1242-1_16, but it redirected us to https://link.springer.com/protocol/10.1007/978-1-4939-1242-1_16. The analysis below is for the second page.

Title[redir]:
SELEX-seq: A Method for Characterizing the Complete Repertoire of Binding Site Preferences for Transcription Factor Complexes | SpringerLink
Description:
The closely related members of the Hox family of homeodomain transcription factors have similar DNA-binding preferences as monomers, yet carry out distinct functions in vivo. Transcription factors often bind DNA as multiprotein complexes, raising the possibility that...

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Keywords {🔍}

pubmed, article, google, scholar, cas, hox, transcription, mann, factors, central, binding, specificities, protocol, specificity, selexseq, dna, usa, york, privacy, cookies, content, information, publish, genes, riley, slattery, bussemaker, dnabinding, dev, department, university, data, preferences, search, factor, complexes, chapter, biol, cell, taipale, download, columbia, springer, usd, site, analysis, personal, log, journal, research,

Topics {✒️}

basic helix-loop-helix proteins genome-wide tissue-specific occupancy month download article/chapter characterize dna-binding specificities estimating dna-binding specificities similar dna-binding preferences hox-based multiprotein complexes termed selex-seq hox cofactor homothorax privacy choices/manage cookies dna-binding specificities louvain-la-neuve device instant download selex-seq platform human transcription factors dna binding specificity editor information editors matthew slattery transcription factor complexes abdominal hox proteins monomeric hox factors hox protein mediated hox protein ultrabithorax minnesota medical school binding site preferences homeodomain transcription factors similar transcription factors ets transcription factors european economic area minor groove structure nih grants r01gm054510 conditions privacy policy box protein specificity hox gene function competing nuclear import bind specific ligands selex-seq journal finder publish accepting optional cookies closely related members limb primordia development main content log hox genes protocol usd 49 hox proteins transcription factor genes dev 13 genes dev 25 social media dahong liu & harmen

Schema {🗺️}

ScholarlyArticle:
      headline:SELEX-seq: A Method for Characterizing the Complete Repertoire of Binding Site Preferences for Transcription Factor Complexes
      pageEnd:278
      pageStart:255
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      genre:
         Springer Protocols
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         name:Hox Genes
         isbn:
            978-1-4939-1242-1
            978-1-4939-1241-4
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                     name:Department of Applied Physics and Applied Mathematics, Columbia University, New York, USA
                     type:PostalAddress
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      keywords:Hox proteins, Transcription factor specificity, Extradenticle, Pbx, SELEX, Next-generation sequencing, Computational analysis
      description:The closely related members of the Hox family of homeodomain transcription factors have similar DNA-binding preferences as monomers, yet carry out distinct functions in vivo. Transcription factors often bind DNA as multiprotein complexes, raising the possibility that complex formation might modify their DNA-binding specificities. To test this hypothesis we developed a new experimental and computational platform, termed SELEX-seq, to characterize DNA-binding specificities of Hox-based multiprotein complexes. We found that complex formation with the same cofactor reveals latent specificities that are not observed for monomeric Hox factors. The findings from this in vitro platform are consistent with in vivo data, and the “latent specificity” concept serves as a precedent for how the specificities of similar transcription factors might be distinguished in vivo. Importantly, the SELEX-seq platform is flexible and can be used to determine the relative affinities to any DNA sequence for any transcription factor or multiprotein complex.
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