DOI . ORG {}

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We began analyzing https://link.springer.com/chapter/10.1007/978-1-4615-2996-5_33, but it redirected us to https://link.springer.com/chapter/10.1007/978-1-4615-2996-5_33. The analysis below is for the second page.

Title[redir]:
A Novel Glycoprotein of Feline Infectious Peritonitis Coronavirus Contains a KDEL-like Endoplasmic Reticulum Retention Signal | SpringerLink
Description:
A new protein of the feline infectious peritonitis virus (FIPV) was discovered in lysates of infected cells. Expression of the gene encoding open reading frame (ORF) 6b of FIPV in recombinant vaccinia virus infected cells was used to identify it as the 6b protein. It...

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🌠 Phenomenal Traffic: 5M - 10M visitors per month

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Keywords {🔍}

google, scholar, article, chapter, spaan, protein, cas, feline, horzinek, virus, pubmed, privacy, cookies, information, publish, coronaviruses, infectious, peritonitis, vennema, heijnen, content, research, search, glycoprotein, signal, rottier, medicine, open, cell, sequence, wjm, virology, springer, data, journal, kdellike, experimental, fipv, download, access, keywords, laude, nature, biol, function, optional, media, personal, parties, policy,

Topics {✒️}

c-terminal sequence ktev endo-ß-n-acetylglucosaminidase amino acid sequence sequence kdel consensus kdel-signal soluble protein contained privacy choices/manage cookies er-retention signal main content log mutant 6b protein cell tropisms fipv 6b protein viral glycoprotein references groot keywords feline pract chapter cite cell biol european economic area reverse genetics systems receptor binding sites learning algorithm improves van der zeijst jouy-en-josas journal finder publish conditions privacy policy accepting optional cookies book series 6b protein chapter coronaviruses functional kdel cell viral protein glycoprotein chapter vennema infected cells social media affiliations department permissions reprints journal publish kdel protein privacy policy personal data ma books a optional cookies manage preferences c-terminus authors

Schema {🗺️}

ScholarlyArticle:
      headline:A Novel Glycoprotein of Feline Infectious Peritonitis Coronavirus Contains a KDEL-like Endoplasmic Reticulum Retention Signal
      pageEnd:214
      pageStart:209
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4615-2996-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Coronaviruses
         isbn:
            978-1-4615-2996-5
            978-1-4613-6305-7
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:H. Vennema
            affiliation:
                  name:University of Utrecht
                  address:
                     name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:L. Heijnen
            affiliation:
                  name:University of Leiden
                  address:
                     name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:P. J. M. Rottier
            affiliation:
                  name:University of Utrecht
                  address:
                     name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. C. Horzinek
            affiliation:
                  name:University of Utrecht
                  address:
                     name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:W. J. M. Spaan
            affiliation:
                  name:University of Leiden
                  address:
                     name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Recombinant Vaccinia Virus, Radio Immunoprecipitation Assay, Feline Infectious Peritonitis Virus, Sequence KDEL, Protein Produce Cell
      description:A new protein of the feline infectious peritonitis virus (FIPV) was discovered in lysates of infected cells. Expression of the gene encoding open reading frame (ORF) 6b of FIPV in recombinant vaccinia virus infected cells was used to identify it as the 6b protein. It is a novel type of viral glycoprotein whose function is not clear. It is a soluble protein contained in microsomes; its slow export from the cell is caused by the presence of an ER-retention signal at the C-terminus. This amino acid sequence, KTEL, closely resembles the consensus KDEL-signal of soluble resident ER proteins. A mutant 6b protein with the C-terminal sequence KTEV became resistant to digestion by endo-ß-N-acetylglucosaminidase H with a half-time that was reduced threefold. In contrast, a mutant with the sequence KDEL was completely retained in the ER. The FIPV 6b protein is the first example of a viral protein with a functional KDEL-like ER-retention signal.
      datePublished:1994
      isAccessibleForFree:1
      context:https://schema.org
Book:
      name:Coronaviruses
      isbn:
         978-1-4615-2996-5
         978-1-4613-6305-7
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Utrecht
      address:
         name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
         type:PostalAddress
      name:University of Leiden
      address:
         name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands
         type:PostalAddress
      name:University of Utrecht
      address:
         name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
         type:PostalAddress
      name:University of Utrecht
      address:
         name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
         type:PostalAddress
      name:University of Leiden
      address:
         name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:H. Vennema
      affiliation:
            name:University of Utrecht
            address:
               name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:L. Heijnen
      affiliation:
            name:University of Leiden
            address:
               name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:P. J. M. Rottier
      affiliation:
            name:University of Utrecht
            address:
               name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:M. C. Horzinek
      affiliation:
            name:University of Utrecht
            address:
               name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:W. J. M. Spaan
      affiliation:
            name:University of Leiden
            address:
               name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
      name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands
      name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
      name:Department of Virology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
      name:Department of Virology, Faculty of Medicine, University of Leiden, The Netherlands

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