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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers

We began analyzing https://link.springer.com/chapter/10.1007/82_2015_478, but it redirected us to https://link.springer.com/chapter/10.1007/82_2015_478. The analysis below is for the second page.

Title[redir]:
BTK Signaling in B Cell Differentiation and Autoimmunity | SpringerLink
Description:
Since the original identification of Bruton’s tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we...

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 8,426,036 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't tell how the site generates income.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, google, scholar, cas, article, cell, kinase, tyrosine, immunol, central, mice, cells, brutons, btk, receptor, xlinked, med, exp, signaling, hendriks, xid, immunity, activation, preb, van, agammaglobulinemia, bcell, biol, immunodeficiency, antigen, arthritis, protein, domain, steinberg, witte, defect, sci, usa, nat, development, dingjan, rawlings, function, regulation, proc, natl, acad, immune, chapter, differentiation,

Topics {✒️}

lfm-a13 [alpha-cyano-beta-hydroxy-beta-methyl-n c-jun nh2-terminal kinase autoimmune c3h-gld/gld mice b-cell receptor-induced phosphorylation x-linked b-lymphocyte defect pre-b-cell receptor signalling x-linked agammaglobulinemia locus month download article/chapter defective il-5-receptor-mediated signaling enhancer-mediated chromatin interactions modified gamma-retrovirus vector restriction fragment-length polymorphism x-linked immunodeficiency phenotype extracellular signal-regulated kinase surrogate-light-chain silencing immunoglobulin subclass-specific immunodeficiency b-cell subpopulations identified congenic mrl-ipr/ipr immunoglobulin heavy-chain transcription cell receptor-mediated signaling x-linked immune defect retroviral-mediated gene transfer membrane-anchored adaptor protein synthetic double-stranded rna phospholipase c-gamma2 stabilizes b-cell receptor activation inhibits bcr-induced activation cell-activating factor receptor x-linked gene plays myeloid cell-mediated arthritis refractory mantle-cell lymphoma human x-linked agammaglobulinemia antigen receptor-intrinsic costimulation x-linked immunodeficient mice x-linked immunodeficiency genes influenza virus-infected mice grb2-btk signalling module antigen receptor-stimulated splenic systemic autoimmune disease b-cell differentiation pathway experimental murine filariosis–association beta gamma subunits de bruijn mf van loo pf tyrosine-kinase-deficient murine x-linked immunodeficient x-linked immunodeficiency tyrosine kinase induces surface immunoglobulin receptors igg-transgenic mouse line

Schema {🗺️}

ScholarlyArticle:
      headline:BTK Signaling in B Cell Differentiation and Autoimmunity
      pageEnd:105
      pageStart:67
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-26133-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:B Cell Receptor Signaling
         isbn:
            978-3-319-26133-1
            978-3-319-26131-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Odilia B. J. Corneth
            affiliation:
                  name:Erasmus MC Rotterdam
                  address:
                     name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roel G. J. Klein Wolterink
            affiliation:
                  name:Erasmus MC Rotterdam
                  address:
                     name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rudi W. Hendriks
            affiliation:
                  name:Erasmus MC Rotterdam
                  address:
                     name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:LPSLipopolysaccharide (LPS), SLE Systemic Lupus Erythematosus, Spleen Tyrosine Kinase, Collagen-induced Arthritis, influenzaInfluenza
      description:Since the original identification of Bruton’s tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial signal transducer of signals downstream of the IgM or IgG B cell antigen receptor (BCR) in mature B cells governing proliferation, survival, and differentiation. In particular, we highlight BTK function in B cells in the context of host defense and autoimmunity. Small-molecule inhibitors of BTK have very recently shown impressive anti-tumor activity in clinical studies in patients with various B cell malignancies. Since promising effects of BTK inhibition were also seen in experimental animal models for lupus and rheumatoid arthritis, BTK may be a good target for controlling autoreactive B cells in patients with systemic autoimmune disease.
      datePublished:2015
      isAccessibleForFree:
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Book:
      name:B Cell Receptor Signaling
      isbn:
         978-3-319-26133-1
         978-3-319-26131-7
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Erasmus MC Rotterdam
      address:
         name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
         type:PostalAddress
      name:Erasmus MC Rotterdam
      address:
         name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
         type:PostalAddress
      name:Erasmus MC Rotterdam
      address:
         name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Odilia B. J. Corneth
      affiliation:
            name:Erasmus MC Rotterdam
            address:
               name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Roel G. J. Klein Wolterink
      affiliation:
            name:Erasmus MC Rotterdam
            address:
               name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Rudi W. Hendriks
      affiliation:
            name:Erasmus MC Rotterdam
            address:
               name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
      name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
      name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(642)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com
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