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Title[redir]:
Hepatology
Description:
e patients with HCC receive systemic therapies, traditionally sorafenib or lenvatinib, as a firstâline therapy. In the last few years, immuneâcheckpoint inhibitors (ICIs) have revolutionized cancer therapy and have gained an increased interest in the treatment of HCC. In 2020, the combination of atezolizumab (antiâprogrammed deathâligand 1) and bevacizumab (antiâvascular endothelial growth factor) improved overall survival over sorafenib, resulting in Food and Drug Administration (FDA) approval as a firstâline treatment for patients with advanced HCC. Despite these major advances, a better molecular and cellular characterization of the tumor microenvironment is still needed because it has a crucial role in the development and progression of HCC. Inflamed (hot) and noninflamed (cold) HCC tumors and genomic signatures have been associated with response to ICIs. However, there are no additional biomarkers to guide clinical decisionâmaking. Other immuneâtargeting strategies, such as adoptive Tâcell transfer, vaccination, and virotherapy, are currently under development. This review provides an overview on the HCC immune microenvironment, different cellular players, current available immunotherapies, and potential immunotherapy modalities....
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Keywords {đ}
cells, hcc, cell, tumor, patients, liver, cancer, expression, immune, tumors, monocytes, activation, growth, figure, macrophages, survival, dcs, clinical, sorafenib, combination, pdl, antitumor, treatment, tme, ccl, shown, high, tgfβ, mice, immunosuppressive, human, tams, advanced, progression, potential, tans, recruitment, factor, role, activity, nct, cytokines, therapies, receptor, targeting, blood, pathway, neutrophils, promote, recently,
Topics {âď¸}
mirâ146aâ5pâembedded exosomes secreted pmnâmdscâcd11b+cd33+hlaâdrâ ctnnb1âmutated subclasses g5âg6 granulocyteâmacrophage colonyâstimulating factor high ccrk/ilâ6/cd11b/cd33 expression chimeric receptor nkg2dâcd3Îśâdap10 gutâmicrobiotaâliver axis represents hif1a/nfâÎşb/cxcl5 pathway gpc3+asgr1+hcc xenograft models circulating cd14+hlaâdrhigh monocytes dcâmediated antigen crossâpresentation antiâpdâl1 showed reduced advanced tumorânodeâmetastasis stage tlr9/nfâÎşb pathway rafâmekâerk cascade hccâbearing mouse model induce cd4+cd25+foxp3+ tregs mirâ301bâ3p expression yolk sacâderived precursors guide clinical decisionâmaking antibodyâdependent cellular cytotoxicity patient tumorânodeâmetastasis stages cd33+cdâ11b+âmdscs tumorâsurrounding fibrotic livers humanized antiânkg2a antibody costimulatory molecule icoslâ41bb219 wnt/βâcatenin pathway immunodeficient tumorâbearing mice antiâprogrammed deathâligand 1 igdâigg+cd27âcd38â highâfat diet tissueâdraining lymph nodes120 peritumoral cd86+hlaâdr+ monocytes csfâ1r inhibitor plx3397 inhibitory immuneâcheckpoint receptors affecting cellâcycle control tumorâbearing immunocompromised mice nkâmediated therapeutic strategies longâterm side effects antiâilâ6 antibody siltuximab met/csf1r/src inhibitor aasld practice guideline castrationâresistant prostate cancer singleâcell rna sequencing inhibitory immuneâcheckpoint ligands lower diseaseâfree survival sdf1a/cxcr4/ilâ6 pathway interferon γ [ifnâÎł] nkâbased cik therapies gutâderived microbial metabolites
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