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Title[redir]:
Hepatology
Description:
the BM-MSCs leading to unsatisfactory efficacy remains a major concern. Gender differences have been suggested in BM-MSCs therapeutic application, but the effect of the androgen receptor (AR), a key factor in male sexual phenotype, in this application is not clear. Using two liver cirrhosis mouse models induced by CCl4 or thioacetamide, we showed that targeting AR in the BM-MSCs improved their self-renewal and migration potentials and increased paracrine effects to exert anti-inflammatory and anti-fibrotic actions to enhance liver repair. Mechanism dissection studies suggested that knocking out AR in BM-MSCs led to improved self-renewal and migration by alteration of the signaling of epidermal growth factor receptor and matrix metalloproteinase 9 and resulted in suppression of infiltrating macrophages and hepatic stellate cell activation through modulation of interleukin (IL)1R/IL1Ra signaling. Therapeutic approaches using either AR/small interfering RNA or the AR degradation enhancer, ASC-J9®, to target AR in BM-MSCs all led to increased efficacy for liver repair.Conclusion: Targeting AR, a key factor in male sexual phenotype, in BM-MSCs improves transplantation therapeutic efficacy for treating liver fibrosis....
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Keywords {🔍}
liver, bmmscs, aasld, transplantation, log, journal, efficacy, access, hepatology, subscribe, issue, alerts, abstract, targeting, receptor, cirrhosis, therapeutic, factor, clinical, disease, register, member, logo, browse, submit, androgen, bone, marrow, mesenchymal, stem, cells, therapy, buy, suggested, application, key, male, sexual, phenotype, improved, selfrenewal, migration, increased, led, signaling, copyright, american, association, study, diseases,
Topics {✒️}
aasld members log ar/small interfering rna bm-mscs therapeutic application replacing liver transplantation treat liver cirrhosis open access policy transplantation therapy efficacy liver cancer development treating liver fibrosis androgen receptor enhance liver repair individual subscribers log bm-mscs leading unsatisfactory efficacy remains institutional users access low survival rate male sexual phenotype exert anti-inflammatory anti-fibrotic actions artificial intelligence training bm-mscs improved bm-mscs led clinical trials irreversible disease increased paracrine effects liver diseases full text access ar degradation enhancer 1r/il1ra signaling liver repair journal tables register subscribe bm-mscs service request 800-638-3030 targeting ar therapeutic approaches increased efficacy journal key factor website subscribe alternative therapy target ar chiung-kuei1 soo ok1 kuo-pao1 wen-lung1 tzu-hua1 meng-yin3 eventually lead major concern
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