
DOI . ORG {
}
Title[redir]:
Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K+ efflux - Rühl - 2015 - European Journal of Immunology - Wiley Online Library
Description:
Recognition of microbe-associated molecular patterns or endogenous danger signals by a subset of cytosolic PRRs results in the assembly of multiprotein signaling complexes, the so-called inflammasome...
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Keywords {🔍}
nlrp, caspase, cells, activation, fig, asc, lps, inflammasome, release, bmdms, ilβ, cell, ros, mitochondrial, medium, transfection, death, formation, levels, analysis, efflux, results, speck, ldh, nigericin, transfected, staining, canonical, noncanonical, independent, intracellular, reduced, experiments, data, flow, information, pathway, nac, stimulation, pbfi, pamcskprimed, figure, cytometry, production, sufficient, measured, supporting, mitotempo, kcl, danger,
Topics {✒️}
ros scavenger n-acetyl-cysteine casp11−/− bm-derived macrophages dss-cross-linked nonsoluble fractions card domain 17 alexa-568 conjugated anti-rat-antibodies nlrp3-induced il-1β production lsm700-upright confocal microscope cocultured pam3csk4-primed wt/wt goat-anti-rabbit-hrp rabbit-anti-hmgb-1 rabbit-anti-mouse-hrp goat-anti-il-1β pyhin protein family cell-autonomous level independently rat-anti-asc antibodies dss cross-linking kantonales veterinäramt basel-stadt rabbit-anti-caspase-1 p10 rabbit-anti-alpha-tubulin caspase-11-induced cell death additional studies aimed fluorescent indicator pbfi caspase-11-mediated nlrp3 activation pam3csk4-primed wt bmdms caspase-11-induced nlrp3 activation casp-11-deficient macrophages article information search caspase-11-driven nlrp3 activation caspase-11-triggered nlrp3 activation infrared live–dead marker nlrp3–asc speck formation figure viewer powerpoint cocultured casp11-deficient cells il-1β production rabbit-anti-goat mitochondrial ros indicator pyhin family members lps-transfected wt bmdms wt macrophages stimulated il-1β secretion processed il-1β/-18 cell-autonomous level reduce mitochondrial ros recruitment mitochondrial ros production fortessa flow cytometer cell-autonomous manner active caspase-11 triggers hin-domain mouse-anti-nlrp3
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