Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://journals.lww.com/hep/abstract/2008/11000/translocation_of_iron_from_lysosomes_into.33.aspx, but it redirected us to https://journals.lww.com/hep/abstract/2008/11000/translocation_of_iron_from_lysosomes_into.33.aspx. The analysis below is for the second page.

Title[redir]:
Hepatology
Description:
ovement of chelatable iron in oxidative stress-induced killing to cultured hepatocytes from C3Heb mice and Sprague-Dawley rats. Mitochondrial polarization and chelatable iron were visualized by confocal microscopy of tetramethylrhodamine methylester (TMRM) and quenching of calcein, respectively. Cell viability and hydroperoxide formation (a measure of lipid peroxidation) were measured fluorometrically using propidium iodide and chloromethyl dihydrodichlorofluorescein, respectively. After collapse of lysosomal/endosomal acidic pH gradients with bafilomycin (50 nM), an inhibitor of the vacuolar proton-pumping adenosine triphosphatase, cytosolic calcein fluorescence became quenched. Deferoxamine mesylate and starch-deferoxamine (1 mM) prevented bafilomycin-induced calcein quenching, indicating that bafilomycin induced release of chelatable iron from lysosomes/endosomes. Bafilomycin also quenched calcein fluorescence in mitochondria, which was blocked by 20 μM Ru360, an inhibitor of the mitochondrial calcium uniporter, consistent with mitochondrial iron uptake by the uniporter. Bafilomycin alone was not sufficient to induce mitochondrial depolarization and cell killing, but in the presence of low-dosetert-butylhydroperoxide (25 μM), bafilomycin enhanced hydroperoxide generation, leading to mitochondrial depolarization and subsequent cell death.Conclusion:Taken together, the results are consistent with the conclusion that bafilomycin induces release of chelatable iron from lysosomes/endosomes, which is taken up by mitochondria. Oxidative stress and chelatable iron thus act as two “hits” synergistically promoting toxic radical formation, mitochondrial dysfunction, and cell death. This pathway of intracellular iron translocation is a potential therapeutic target against oxidative stress–mediated hepatotoxicity. (Hepatology 2008.) Abbreviations: cmDCF, chloromethyldichlorofluorescein; cmH2DCF-DA, chloromethyldihydrodichlorofluorescein diacetate; HEPES, 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid; MPT, mitochondrial permeability transition; O2•−, superoxide; OH•, hydroxyl radical; PI, propidium iodide; ROS, reactive oxygen species; t-BuOOH, tert-butylhydroperoxide; TMRM, tetramethylrhodamine methylester....

Matching Content Categories {📚}

  • Telecommunications
  • Health & Fitness
  • Games

Content Management System {📝}

What CMS is doi.org built with?


Doi.org operates using MYBB.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 91,705,781 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We're unsure how the site profits.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

iron, liver, mitochondrial, bafilomycin, aasld, chelatable, hepatology, log, journal, oxidative, calcein, cell, access, subscribe, issue, alerts, abstract, mitochondria, diseases, register, member, logo, browse, submit, article, translocation, lysosomes, stressinduced, hepatocellular, injury, buy, hepatocytes, role, intracellular, killing, mice, tetramethylrhodamine, methylester, tmrm, quenching, hydroperoxide, formation, propidium, iodide, inhibitor, fluorescence, quenched, release, lysosomesendosomes, uniporter,

Topics {✒️}

acetaminophen–induced hepatotoxicity back oxidative stress–mediated hepatotoxicity oxidative stress-induced killing aasld members log cholestatic liver open access policy individual subscribers log bafilomycin induced release lysosomal iron participates institutional users access sprague-dawley rats cytosolic calcein fluorescence potential therapeutic target 1-piperazine ethanesulfonic acid reactive oxygen species bile acid homeostasis artificial intelligence training intracellular iron translocation bafilomycin induces release mitochondrial permeability transition low-dosetert-butylhydroperoxide liver diseases full text access induce mitochondrial depolarization mitochondrial iron uptake quenched calcein fluorescence oxidative stress subsequent cell death mitochondrial calcium uniporter hydroperoxide formation journal tables register subscribe hepatology 2008 service request 800-638-3030 hydroxyl radical cell killing mitochondrial depolarization journal cell death website subscribe mitochondrial polarization mitochondrial dysfunction intracellular movement tert-butylhydroperoxide heme iron chelatable iron cell viability key event jae-sung3 precise mechanisms

Questions {❓}

  • AASLD Member?
  • Not a Subscriber?

External Links {🔗}(73)

Analytics and Tracking {📊}

  • Comscore
  • Google Analytics
  • Google Tag Manager
  • Mouseflow

Libraries {📚}

  • Bootstrap
  • FontAwesome
  • jQuery
  • Video.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cookielaw
  • Jsdelivr
  • Mouseflow
  • Scite
  • Wolterskluwer

5.9s.