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Title[redir]:
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations - PubMed
Description:
PIK3CA, one of the two most frequently mutated oncogenes in human tumors, codes for p110alpha, the catalytic subunit of a phosphatidylinositol 3-kinase, isoform alpha (PI3Kalpha, p110alpha/p85). Here, we report a 3.0 angstrom resolution structure of a complex between p110alpha and a polypeptide cont …
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Keywords {🔍}
doi, protein, pmid, structure, palpha, phosphatidylinositol, oncogenic, mutations, kinase, pmc, human, free, article, nih, kinases, states, articles, cited, mesh, dec, effects, gabelli, amzel, pikca, catalytic, domains, activity, oncotarget, subunits, hhsunited, main, access, ncbi, similar, data, resources, science, palphapalpha, pikalpha, subunit, domain, insights, pubmed, gene, epub, feb, mar, research, molecular, genetics,
Topics {✒️}
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