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Title[redir]:
Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma - PubMed
Description:
The p27 tumor suppressor negatively regulates G1 cell cycle progression. However, human malignancies rarely select for deletion/inactivation of p27, a hallmark of tumor suppressor genes. Instead, p27 is degraded or relocalized to the cytoplasm in aggressive malignancies, supporting the notion that p β¦
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Keywords {π}
doi, pmid, cancer, melanoma, cell, cytoplasmic, pkip, kinase, inhibitor, pmc, cyclindependent, epub, free, article, articles, res, tumor, suppressor, oncotarget, genetics, main, ncbi, similar, cited, mesh, information, resources, metastatic, human, pubmed, jan, metabolism, experimental, hhs, page, content, homepage, navigation, search, full, text, abstract, publication, types, terms, substances, related, linkout, oct, relocalized,
Topics {βοΈ}
cyclin-dependent kinase tumor suppressor genes cdk inhibitor p27 main page content interferon-Ξ³-induced p27kip1 binds similar articles cited pi3k-akt-p27 axis basement membrane-confined melanoma bcr-abl1 promotes leukemia selectively dephosphorylating phospho-thr157 nuclear cyclin cytoplasm cyclin melanoma catherine denicourtΒ 1 find cytoplasmic p27 cdk-binding p27 cell cycle cdk-independent cytoplasmic function resources cancer res literature sources cell migration targeted cytoplasmic expression cytoplasmic p27 united states government xian-shu cui 07-1375 abstract morse hc 3rd hydrogen peroxide modulation b56Ξ³3 regulatory subunit proteasome-mediated degradation von der lehr cancer cell p27 sequestration cytosolic p27 converting p27 cell lymphomas late oncogenic role mere nuclear loss nat rev cancer cytoplasmic metastatic oncogene cited p27 16122798 p27 cancer cells subcellular localization p27kip1 regulated aggressive malignancies human cancer pubmed wordmark pubmed logo
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