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Title[redir]:
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes - PubMed
Description:
Tumor necrosis factor alpha (TNF-alpha), a major proinflammatory cytokine, induces arthritic joint inflammation and resorption of cartilage by matrix metalloproteinase-13 (MMP-13). RNA for MMP-13 is increased in human arthritic femoral cartilage. Mechanisms of this induction were investigated by pre …
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Keywords {🔍}
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Topics {✒️}
mitogen-activated protein kinases mitogen-activated protein jnk map kinases c-jun n-terminal kinase interleukin-1-stimulated map kinases nuclear factor kappa map kinases extracellular signal-regulated kinases nf-kappa nf-kappab transcription factors main page content mmp-13 rna/protein similar articles cited human articular chondrocytes activating protein-1 inducing matrix metalloproteinase-3 protein transcription factors ap-1 matrix metalloproteinase-13 articular chondrocytes mesh terms cartilage kinases literature sources femoral head chondrocytes tnf-alpha signal transduction target transcription factors jnk nf-kappab human chondrocytes primary chondrocytes blocking iκb degradation 14709335 interleukin-1 induction potential inhibitors proteasome inhibitors map aggrecanase gene expression matrix biol transcription factors mesh keyword tnf-stimulated expression reducing cartilage breakdown inhibitors tnf-alpha signaling cell physiol biochem mapk signaling pathway p38 united states government induction major proinflammatory cytokine cell mol med
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