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writing—original draft preparation data availability statement pmc beta search driving cell-mediated immunity age/gender-matched healthy controls retinal vascular/neuronal degeneration endotoxin-induced inflammatory environment independent samples t-test increased anti-inflammatory activity post-golgi trafficking pathways low-grade cellular activation cross-sectional study design pg/mg total protein statistically significant differences post-fluorochrome staining cell ifn-γ production irregular ifn-γ expression gender-matched healthy controls pbmc-derived ifn-γ anti-inflammatory immune mechanisms defective il-6 trafficking/signaling il-6-producing myeloid cells impaired ifn-γ production dye-conjugated antibodies diminished ifn-γ observed elevated pbmc-released il-10 reduced ifn-γ expression locally produced il-17a ifn-γ expression compared publisher site pdf epidermal growth factor bone marrow microenvironment funding statement [google scholar] 24 considered statistically significant statistically significant difference pbmc flow cytometry data availability statements protein transport inhibitor functions including maturation activating il-1-mediated inflammation circulating leukocyte alterations leukocyte-derived cytokines il-6+cd11b+ cells alongside independent samples student increased il-1α secretion prevents cytokine secretion single cell suspension footnotes disclaimer/publisher ifn-γ+cd3+ cells

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