
NCBI . NLM . NIH . GOV {
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Title[redir]:
Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment - PMC
Description:
Tumor microenvironment (TME) provides the essential prerequisite niche for promoting cancer progression and metastasis. Calebin A, a component of Curcuma longa, has long been investigated as a safe multitargeted agent with antitumor and ...
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Keywords {🔍}
doi, cells, tme, proinflammatory, cancer, calebin, pubmed, google, scholar, multicellular, tumor, crc, hct, cultures, cell, article, pmc, free, nfκb, tnfβ, control, proliferation, activation, fibroblasts, role, microenvironment, results, tlymphocytes, tnfβtme, alginate, culture, figure, dalginate, aggarwal, colorectal, basal, stem, cscs, inflammation, invasion, experiments, potential, similar, growth, compared, progression, survival, cytokines, performed, stromal,
Topics {✒️}
nf-κb-regulated gene end-products positively labeled p65-nf-κb-nuclei nf-κb-induced gene products nf-κb-regulated gene products nf-kappab-regulated gene products tnf-β-tme-induced rigorous upregulation tnf-alpha-induced mitochondrial alterations transcription factor p65-nf-κb phospho-specific p65-nf-κb anti-phospho-p65-nf-κb nf-κb-dependent transcription factors tnf-β-tme-induced crc proliferation nf-κb-promoting proinflammatory mediators blocks tnf-β-induced activation proinflammatory cytokine tnf-β-tme tnf-β-tme-induced phosphorylation t-lymphocytes activated nf-κb transcription factor nf-κb inhibit tnf-β-induced survival tnf-β-tme cultures compared chitosan-alginate 3d scaffolds nf-κb signaling pathway proinflammatory monocellular-tme culture pmc beta search nf-κb signaling pathways 5-bromo-4-chloro-3-indoyl-phosphate wilcoxon–mann–whitney test multicellular-tme-induced phosphorylation suppresses nf-kappab activation alkaline phosphatase-linked antibodies p65-nf-κb subunits maintaining nf-κb phosphorylation anti-p65-nf-kb proinflammatory cytokine tnf-β alginate hct116 3d-alginate tnf-β induced tme multicellular-tme-induced malignancy nf-κb-promoted proteins conventional 2d-tumor cultures 3d-alginate tumor cultures �tnf-β-tme” culture multicellular tme-induced inflammation multicellular pro-inflammatory tme nuclear factor-kappab p65 including plant-derived compounds tnf-β-tme-enhanced secondary rhodamine-coupled antibodies pbs/bovine serum albumin �tnf-β-tme” cultures tnf-β-tme cultures
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