
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer - PMC
Description:
Though the gut microbiome has been associated with efficacy of immunotherapy (ICI) in certain cancers, similar findings have not been identified for microbiomes from other body sites and their correlation to treatment response and immune related ...
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Keywords {๐}
doi, patients, microbiome, pubmed, google, scholar, samples, cancer, response, gut, pmc, immunotherapy, article, free, study, analysis, nasal, buccal, iraes, lung, patient, ici, development, data, microbiota, toxicity, fig, phylum, relative, firmicutes, sample, fecal, treatment, responders, identified, baseline, ฮฑdiversity, abundance, disease, therapy, bifidobacterium, enrichment, resolution, bacteria, zhang, findings, sites, immune, cohort, prior,
Topics {โ๏ธ}
false discovery rate short-chain fatty acids methylazoxymethanol-b-d-glucosiduronic acid squares-discriminant analysis immune-related adverse effects iciโ=โimmune checkpoint inhibitor platinum-etoposide versus platinum-etoposide anti-pd-l1 agent durvalumab facilitates anti-pd-l1 efficacy principal coordinate analysis small-cell lung cancer immune-mediated adverse effects advanced/metastatic lc planned develop immune-related toxicities checkpoint inhibitor status event single-center academic institution experienced complete response anti-pd-l1 therapy [17โ19] immune-related colitis g-protein coupled receptors immune checkpoint inhibition immune checkpoint inhibitors germfree sprague-dawley rats bray-curtis indices showed reduce pro-inflammatory cytokines single-agent regimen log-adjusted relative abundances foster anti-tumor effects fine-tuning cancer immunotherapy pmc beta search small sample size pair-end reads remaining cr o'connell pr median progression-free survival patient/parent/guardian/ relative pls-da higher baseline ฮฑ-diversity ae/irae severity immune checkpoint complete recovery healthy control pulmonary-intestinal cross-talk undergo immunotherapy-based treatment pd-l1 therapy [20] existing regulatory t-cells developing life-threatening iraes 34256732 abstract background funding bodies played
Questions {โ}
- The impact of tumor and gut microbiotas on cancer therapy: Beneficial or detrimental?
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