
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma - PMC
Description:
Glioma-associated myeloid cells generate polyamines to survive and function within the acidic tumor microenvironment.
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Keywords {🔍}
cells, tamcs, dfmo, google, scholar, doi, pubmed, mice, tumor, fig, pmc, article, free, myeloid, analysis, polyamine, cell, performed, survival, polyamines, days, cancer, data, metabolic, tumors, treatment, intracellular, glioma, analyzed, vivo, flux, immunosuppression, expression, generated, gbm, brain, glioblastoma, generation, isolated, metabolism, putrescine, hours, acidic, immune, arginine, cta, dfmotreated, min, ornithine, samples,
Topics {✒️}
org/cgi/content/full/7/8/eabc8929/dc1 references org/cgi/content/full/7/8/eabc8929/dc1 articles / tosyl-l-lysyl-chloromethane hydrochloride cd45+cd3+cd4+cd8−foxp3+cd25+ melittin-based pro-apoptotic peptide antigen-specific t-cell responses anti–tgf-β–lap bv711 inhibits mdsc-mediated suppression cd45+cd3+cd4+cd8−foxp3− ct-2a tumor–bearing animals transforming growth factor–β assessed 13c-glucose flux ct-2a glioma–bearing mice anti-c11b pacific blue lc-ms/ms analysis revealed anti-biotin magnetic beads anti-cd4 pe-cy7 anti-cd3 pe-cy7 pmc beta search long-term antitumor immunity immune-stimulatory gene therapy myeloid-derived suppressor cells 13c-arginine silac medium mouse tail illuminator/restrainer large-scale “omics” approaches oxidative phosphorylation-driven immunosuppression cell necrosis/apoptotic measurement cell–driven antitumor immunity hif-1α regulates function vivo 13c-glucose flux anti-cd11b–alexa fluor 488 1-ml luer-lock syringes ph-low insertion peptide urea cycle/inos pathway glioma-infiltrating cellular subsets single-cell transcriptome analysis anti–pd-l1 pe restore anti-tumor immunity ct-2a tumor line influence antigen-specific responses anti-tumor immune response adaptive immune responses pd–pd-l1 pathway lc-ms/ms analyses arginine-ornithine-polyamine axis specifically target m-mdscs anti–pd-l1 treatment ct-2a tumor implantation pd-1/pd-l1 mechanism publisher site pdf
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