
NCBI . NLM . NIH . GOV {
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Title[redir]:
Targeting TGFβ signal transduction for cancer therapy - PMC
Description:
Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis. ...
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Keywords {🔍}
doi, tgfβ, google, scholar, pubmed, cancer, pmc, article, free, cell, cells, tumor, growth, patients, nct, signaling, phase, combination, transforming, therapy, advanced, receptor, clinical, tumors, immune, protein, kinase, factor, study, biol, antitumor, activation, smad, inhibitor, monotherapy, breast, metastatic, factorβ, treatment, expression, solid, res, targeting, antibody, pathway, tβri, recruiting, completed, clin, latent,
Topics {✒️}
anti-transforming growth factor-β breast/lung/hepatocellular/colorectal/pancreatic/renal cancer overcome chemo/targeted/radio-therapy resistance tgf-β-induced epithelial–mesenchymal transition tgf-β-induced epithelial-mesenchymal transition tgf-β-mediated epithelial-mesenchymal transition recurrent/refractory high-grade glioma chimeric erythropoietin-tgf-β receptors transforming growth factor-β anti-pd-l1 antibody mpdl3280a tgf-β-induced foxp3 inhibits tgf-β-driven program transforming growth factor-β1 latent tgf-β1-binding protein cross-species single-cell analysis platelet-derived growth factor pan anti-tgfβ-neutralizing antibody pan-tgfβ ligand-neutralizing antibody transforming growth factor-β3 tgfβ-regulated mad-related protein anti-pd-1 immunotherapy-resistant tumors pd-l1-mediated signaling pathways target anti-tgf-β therapies triple-negative breast cancer receptor kinase-independent manner her2-negative breast cancer tgf-β utilizes smad3 anti-tgf-β2 antisense pd-l1 expressing advanced tgf-β1 receptor type phosphatidylinositol 3-kinase/akt-dependent pathway tgfβ/smad-induced target genes tgf-β-induced rhoa single-molecule force spectroscopy negatively regulates tgf-β tgf-β responsive signature acute myeloid leukemia ph-responsive clustered nanoparticles distinct tgf-β type cutaneous squamous-cell carcinomas tgf-β antibody uptake latent tgf-β structure α-smooth muscle actin c-myc gene transcription mitogen-activated protein kinase tgf-β orchestrates fibrogenic transforming growth factor tgf-β receptor complex tgf-β receptor signaling small-molecule kinase inhibitors
Questions {❓}
- On-target anti-TGF-β therapies are not succeeding in clinical cancer treatments: what are remaining challenges?
- Transforming growth factor β: tumor suppressor or promoter?
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol.&title=Proteolytic%20activation%20of%20latent%20transforming%20growth%20factor-%CE%B2%20from%20fibroblast-conditioned%20medium&author=RM%20Lyons&author=J%20Keski-Oja&author=HL%20Moses&volume=106&publication_year=1988&pages=1659-1665&pmid=2967299&doi=10.1083/jcb.106.5.1659&
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- What's the income of https://scholar.google.com/scholar_lookup?journal=EMBO%20J.&title=GS%20domain%20mutations%20that%20constitutively%20activate%20T%CE%B2RI,%20the%20downstream%20signaling%20component%20in%20the%20TGF-%CE%B2%20receptor%20complex&author=R%20Wieser&author=JL%20Wrana&author=J%20Massagu%C3%A9&volume=14&publication_year=1995&pages=2199-2208&pmid=7774578&doi=10.1002/j.1460-2075.1995.tb07214.x&?
- What's the income of https://doi.org/10.1074/jbc.272.44.27678?
- Find out how much https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem.&title=T%CE%B2RI%20phosphorylation%20of%20Smad2%20on%20Ser465%20and%20Ser467%20is%20required%20for%20Smad2-Smad4%20complex%20formation%20and%20signaling&author=S%20Abdollah&volume=272&publication_year=1997&pages=27678-27685&pmid=9346908&doi=10.1074/jbc.272.44.27678& earns monthly
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Crit.%20Rev.%20Biochem.%20Mol.%20Biol.&title=Current%20perspectives%20on%20inhibitory%20SMAD7%20in%20health%20and%20disease&author=C%20de%20Ceuninck%20van%20Capelle&author=M%20Spit&author=P%20Ten%20Dijke&volume=55&publication_year=2020&pages=691-715&pmid=33081543&doi=10.1080/10409238.2020.1828260& generate?
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- How much does https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell&title=Smad7%20binds%20to%20Smurf2%20to%20form%20an%20E3%20ubiquitin%20ligase%20that%20targets%20the%20TGF%CE%B2%20receptor%20for%20degradation&author=P%20Kavsak&volume=6&publication_year=2000&pages=1365-1375&pmid=11163210&doi=10.1016/S1097-2765(00)00134-9& bring in each month?
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- https://doi.org/10.1101/cshperspect.a022145's financial summary
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- Income figures for https://doi.org/10.1038/35070086
- Profit of https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol.&title=TGF%CE%B2%20influences%20Myc,%20Miz-1%20and%20Smad%20to%20control%20the%20CDK%20inhibitor%20p15INK4b&author=J%20Seoane&volume=3&publication_year=2001&pages=400-408&pmid=11283614&doi=10.1038/35070086&
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- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Cancer%20Res.&title=TGF-%CE%B2%20and%20%CE%B1v%CE%B26%20integrin%20act%20in%20a%20common%20pathway%20to%20suppress%20pancreatic%20cancer%20progression&author=AF%20Hezel&volume=72&publication_year=2012&pages=4840-4845&pmid=22787119&doi=10.1158/0008-5472.CAN-12-0634&?
- What's the total monthly financial gain of https://doi.org/10.1200/JCO.2020.38.15_suppl.3587?
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