
NCBI . NLM . NIH . GOV {
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Title[redir]:
The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis - PMC
Description:
Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such as neuroprotection or induction of apoptosis and eryptosis. However, the effects of costunolide on pro-survival factors and enzymes in human erythrocytes, ...
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Keywords {🔍}
doi, google, scholar, pubmed, costunolide, erythrocytes, cell, gsh, human, chelerythrine, glutathione, eryptosis, cells, pmc, free, article, costunolideinduced, activity, fig, gpdh, protein, gssg, pkcα, erythrocyte, depletion, shrinkage, inhibition, kinase, inhibitor, treatment, cancer, concentration, data, annexin, biochem, apoptosis, hemolysis, treated, enzyme, induces, study, concentrationdependent, incubation, blood, biol, physiol, lang, intracellular, effect, synthesis,
Topics {✒️}
tgf-beta1/smad2/nrf2-nox4 signaling pathways gsh / l-γ-glutamyl-l-cysteineglycine pkc-alpha-rac1 signaling axis wnt/β-catenin signaling pathways pkc-erk1/2-mtor signaling pathway pma-stimulated pkc-α activation pkc-α-induced akt activation annexin-v-fluos working concentration costunolide-induced annexin v-binding subtype pkc-α translocates setrile-vaccum-filtration-system pkc-α inhibitor chelerythrine pkc-α enhances survival specific conventional pkc-α uplc-q-tof/ms required annexin-v-fluos irreversible dehydrogenase/decarboxylase system saussurea lappa roots annexin-binding buffer contained pmc beta search synthetic lethality-based approaches de la fuente-granada annexin-v-binding cells annexin v-binding cells anti-malarial therapeutic strategies treat anemia-related diseases anti-helicobacter pylori effect costunolide-induced slight decrease volume-sensitive transport pathways mitogen-activated protein kinases diluted annexin-v-fluos inhibit costunolide-induced eryptosis free radical metabolism pro-survival enzyme g6pdh ascorbate-glutathione antioxidant system costunolide dose-dependently enhanced counteracts tumor growth pentose phosphate pathway atp-dependent gsh synthesis red-cell enzyme analysis saussurea lappa costunolide-induced gsh depletion alpha-mediated phosphorylation affect costunolide-induced gsh phorbol ester stimulates publisher site pdf induces hair growth pkc-alpha inhibition dmso-treated cells served dependent pkc-α
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