
NCBI . NLM . NIH . GOV {
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Title[redir]:
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells - PMC
Description:
Recent studies have demonstrated that acquisition of cancer stem-like properties plays an essential role in promoting epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistance in non-small cell lung cancer (NSCLC); however, ...
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Keywords {🔍}
cells, irx, gefitinib, nanog, cancer, expression, doi, pcgr, cell, fig, resistance, pubmed, google, scholar, properties, lung, western, ohd, treatment, china, stem, blotting, pmc, stemlike, protein, tumor, nsclc, article, combination, signaling, results, free, group, tgfβ, cytotoxicity, egfrtki, increased, inhibited, analysis, experiments, transfected, usa, sirna, growth, celllike, stemness, treated, significantly, levels, assay,
Topics {✒️}
beta-catenin-mediated epithelial-mesenchymal transition vdr/plc-gamma1/tgf-beta1/pathway tgf-β/smad signaling-induced irx4 serum‐free opti‐mem media tgf-β/smad signaling pathway28 small-molecule multi-kinase inhibitor20 tgf-β1/smad3 signaling pathway erk1/2-mzf1 signaling pathway pmc beta search tgf-β1/smad3 signaling 2d3 signaling-induced decreases egfr-tyrosine kinase inhibitors egfr-tki resistant cells poor egfr-tki sensitivity small-cell lung cancer irx4-expressing cell lines inhibit egfr-tki resistance cd44+cd133+ pc-9/gr cells regulating egfr-tki resistance irx4-mediated cancer stem increase egfr-tki resistance nanog-mediated stem cell high tgf-β1 levels irx-family genes participate pre-clinical models support contract number hh20190622lhy-lv03 multi-directional differentiation potential pnanog-luc reporter activity ventricular-specific progenitor cell tgf-β1 induced egfr-mutant nsclc cells9 irx4+mouse embryonic cells sirna/plasmid‐lipid complexes tyrosine kinase inhibitors 20 ng/ml tgf-β1 receptor signaling downregulates xenograft mouse model tgf-β1 increased ultra low-attachment plates lung cancer progression cell death dis cell signaling technology license information pmcid publisher site pdf increased growth suppression irx4-induced nanog expression inhibit xenograft growth egfr-tki resistance inhibiting cancer stem egfr-tyrosine kinase3
Questions {❓}
- How IRX4 controls gefitinib cytotoxicity?
- How to regulate IRX4-mediated cancer stem-like properties and gefitinib resistance?
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- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi