
NCBI . NLM . NIH . GOV {
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Title[redir]:
IRF4 instructs effector Treg differentiation and immune suppression in human cancer - PMC
Description:
The molecular mechanisms responsible for the high immunosuppressive capacity of CD4+ Tregs in tumors are not well known. High-dimensional single-cell profiling of T cells from chemotherapy-naive individuals with non–small-cell lung cancer identified ...
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Keywords {🔍}
doi, tregs, irf, cells, pubmed, google, scholar, figure, expression, cell, data, pmc, treg, article, free, supplemental, effector, analysis, ccricos, tumor, cancer, patients, gene, table, mice, genes, lung, regulatory, batf, human, tumors, tumorinfiltrating, differentiation, version, transcriptional, subsets, signature, email, antitumor, ccr, identified, suppressive, immunity, clusters, nature, icos, flow, singlecell, function, performed,
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/luglilab/projectscripts_treg_irf4/blob/master/figure3s/mouse_immunepath_february_01_2019_symbol /luglilab/projectscripts_treg_irf4/blob/master/figure3s/immunosignaturedotplot kaplan-meier disease-free survival high-dimensional single-cell profiling high-throughput single-cell technologies high-dimensional single-cell analysis immune-specific ap-1-irf complexes published single-cell rna-sequencing high-dimensional flow cytometry org/web/packages/survminer/index org/web/packages/survival/index small-cell lung cancer–infiltrating adjacent tumor-free tissues ap-1/irf composite elements higher ccr8+icos+ treg/cd8+ nf-e2-related factor 1 quick-rna microprep kit facs-purified ccr8+icos+ pmc beta search facs-sorted ccr8+icos+ tumor-infiltrating tregs gated high-throughput sequencing data t-sne plots illustrating supplementary materials included human tumor-infiltrating tregs �treg-locking” transcription factors tumor-infiltrating treg signature single-cell flow cytometry kolmogorov-smirnov normality tests sequence alignment/map format k-rasg12d autochthonous model investigated disease-free survival irf4fl/flfoxp3egfp-cre-ert2 cd4+ tumor-infiltrating lymphocytes transcription factor lsirf/irf4 75-bp paired-end reads sorted intratumoral ccr8+icos+ vaccine-mediated antitumor immunity ccr8+icos+ intratumoral tregs tumor-infiltrating treg genes fluorochrome-conjugated antibodies providing ccr8+icos+ effector tregs supplemental data jci-130-130426-s013 single-cell rna-seq small-cell lung cancer small-cell lung cancer ccr8+icos+ tregs define gehan breslow-wilcoxon test cd25+foxp3+ tregs expressing polychromatic flow cytometry
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- https://scholar.google.com/scholar_lookup?journal=Immunity&title=The%20continuum%20of%20cancer%20immunosurveillance:%20prognostic,%20predictive,%20and%20mechanistic%20signatures&author=J%20Galon&author=HK%20Angell&author=D%20Bedognetti&author=FM%20Marincola&volume=39&issue=1&publication_year=2013&pages=11-26&pmid=23890060&doi=10.1016/j.immuni.2013.07.008&'s revenue stream
- What's the monthly income of https://doi.org/10.1038/nature13385?
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Nature&title=Comprehensive%20molecular%20profiling%20of%20lung%20adenocarcinoma&author=%20Cancer%20Genome%20Atlas%20Research%20Network&volume=511&issue=7511&publication_year=2014&pages=543-550&pmid=25079552&doi=10.1038/nature13385&
- How much revenue does https://doi.org/10.1016/j.cell.2017.05.046 bring in?
- How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=Electronic%20address:%[email protected],%20Cancer%20Genome%20Atlas%20Research%20Network.%20Comprehensive%20and%20Integrative%20Genomic%20Characterization%20of%20Hepatocellular%20Carcinoma&author=%20Cancer%20Genome%20Atlas%20Research%20Network&volume=169&issue=7&publication_year=2017&pages=1327-1341.e23&pmid=28622513&doi=10.1016/j.cell.2017.05.046& generate monthly?
- What's the financial outcome of https://doi.org/10.1038/ni.3004?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Continuous%20requirement%20for%20the%20TCR%20in%20regulatory%20T%20cell%20function&author=AG%20Levine&author=A%20Arvey&author=W%20Jin&author=AY%20Rudensky&volume=15&issue=11&publication_year=2014&pages=1070-1078&pmid=25263123&doi=10.1038/ni.3004&?
- How much income does https://doi.org/10.1126/science.1228309 have?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Science&title=A%20genomic%20regulatory%20element%20that%20directs%20assembly%20and%20function%20of%20immune-specific%20AP-1-IRF%20complexes&author=E%20Glasmacher&volume=338&issue=6109&publication_year=2012&pages=975-980&pmid=22983707&doi=10.1126/science.1228309&?
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- What's the profit of https://scholar.google.com/scholar_lookup?journal=Nat%20Commun&title=JunB%20regulates%20homeostasis%20and%20suppressive%20functions%20of%20effector%20regulatory%20T%20cells&author=SI%20Koizumi&volume=9&issue=1&publication_year=2018&pages=5344&pmid=30559442&doi=10.1038/s41467-018-07735-4&?
- https://doi.org/10.1073/pnas.92.20.9097 income
- Earnings of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20USA&title=Cooperative%20transcriptional%20activity%20of%20Jun%20and%20Stat3%20beta,%20a%20short%20form%20of%20Stat3&author=TS%20Schaefer&author=LK%20Sanders&author=D%20Nathans&volume=92&issue=20&publication_year=1995&pages=9097-9101&pmid=7568080&doi=10.1073/pnas.92.20.9097&
- Find out how much https://doi.org/10.1016/j.celrep.2019.10.120 earns monthly
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=IL-33%20signaling%20alters%20regulatory%20T%20cell%20diversity%20in%20support%20of%20tumor%20development&author=A%20Li&volume=29&issue=10&publication_year=2019&pages=2998-3008.e8&pmid=31801068&doi=10.1016/j.celrep.2019.10.120&?
- What is the earnings of https://doi.org/10.1038/s41590-019-0429-7?
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Connecting%20blood%20and%20intratumoral%20Treg%20cell%20activity%20in%20predicting%20future%20relapse%20in%20breast%20cancer&author=L%20Wang&volume=20&issue=9&publication_year=2019&pages=1220-1230&pmid=31285626&doi=10.1038/s41590-019-0429-7&?
- Revenue of https://doi.org/10.1158/2326-6066.CIR-18-0661
- Learn how profitable https://scholar.google.com/scholar_lookup?journal=Cancer%20Immunol%20Res&title=Combined%20low%20densities%20of%20FoxP3+%20and%20CD3+%20tumor-infiltrating%20lymphocytes%20identify%20stage%20II%20colorectal%20cancer%20at%20high%20risk%20of%20progression&author=T%20Cavalleri&volume=7&issue=5&publication_year=2019&pages=751-758&pmid=30804005&doi=10.1158/2326-6066.CIR-18-0661& is on a monthly basis
- How much profit does https://doi.org/10.1038/s41586-019-1215-2 make?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Nature&title=Targeting%20the%20CBM%20complex%20causes%20Treg%20cells%20to%20prime%20tumours%20for%20immune%20checkpoint%20therapy&author=M%20Di%20Pilato&volume=570&issue=7759&publication_year=2019&pages=112-116&pmid=31092922&doi=10.1038/s41586-019-1215-2& make?
- How profitable is https://doi.org/10.1007/978-1-4939-6548-9_3?
- Earnings of https://scholar.google.com/scholar_lookup?journal=Methods%20Mol%20Biol&title=FACS%20analysis%20of%20memory%20T%20lymphocytes&author=E%20Lugli&author=V%20Zanon&author=D%20Mavilio&author=A%20Roberto&volume=1514&publication_year=2017&pages=31-47&pmid=27787790&doi=10.1007/978-1-4939-6548-9_3&
- How much does https://doi.org/10.1038/nbt.3192 rake in every month?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Nat%20Biotechnol&title=Spatial%20reconstruction%20of%20single-cell%20gene%20expression%20data&author=R%20Satija&author=JA%20Farrell&author=D%20Gennert&author=AF%20Schier&author=A%20Regev&volume=33&issue=5&publication_year=2015&pages=495-502&pmid=25867923&doi=10.1038/nbt.3192&?
- How much money does https://doi.org/10.1126/science.275.5299.540 make?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Science&title=Requirement%20for%20the%20transcription%20factor%20LSIRF/IRF4%20for%20mature%20B%20and%20T%20lymphocyte%20function&author=HW%20Mittr%C3%BCcker&volume=275&issue=5299&publication_year=1997&pages=540-543&pmid=8999800&doi=10.1126/science.275.5299.540& generate?
- What's the monthly money flow for https://doi.org/10.1126/science.1191996?
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Science&title=Stability%20of%20the%20regulatory%20T%20cell%20lineage%20in%20vivo&author=YP%20Rubtsov&volume=329&issue=5999&publication_year=2010&pages=1667-1671&pmid=20929851&doi=10.1126/science.1191996&
- Income figures for https://doi.org/10.1038/ni1357
- Earnings of https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Transcription%20factor%20IRF4%20controls%20plasma%20cell%20differentiation%20and%20class-switch%20recombination&author=U%20Klein&volume=7&issue=7&publication_year=2006&pages=773-782&pmid=16767092&doi=10.1038/ni1357&
- How much does https://doi.org/10.1093/bioinformatics/bts635 rake in every month?
- Earnings of https://scholar.google.com/scholar_lookup?journal=Bioinformatics&title=STAR:%20ultrafast%20universal%20RNA-seq%20aligner&author=A%20Dobin&volume=29&issue=1&publication_year=2013&pages=15-21&pmid=23104886&doi=10.1093/bioinformatics/bts635&
- Monthly income for https://doi.org/10.1093/bioinformatics/btu638
- Profit of https://scholar.google.com/scholar_lookup?journal=Bioinformatics&title=HTSeq--a%20Python%20framework%20to%20work%20with%20high-throughput%20sequencing%20data&author=S%20Anders&author=PT%20Pyl&author=W%20Huber&volume=31&issue=2&publication_year=2015&pages=166-169&pmid=25260700&doi=10.1093/bioinformatics/btu638&
- How much revenue does https://doi.org/10.1093/nar/gky955 bring in?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=GENCODE%20reference%20annotation%20for%20the%20human%20and%20mouse%20genomes&author=A%20Frankish&volume=47&issue=D1&publication_year=2019&pages=D766-D773&pmid=30357393&doi=10.1093/nar/gky955&?
- Explore the financials of https://doi.org/10.1093/bioinformatics/btp616
- https://scholar.google.com/scholar_lookup?journal=Bioinformatics&title=edgeR:%20a%20Bioconductor%20package%20for%20differential%20expression%20analysis%20of%20digital%20gene%20expression%20data&author=MD%20Robinson&author=DJ%20McCarthy&author=GK%20Smyth&volume=26&issue=1&publication_year=2010&pages=139-140&pmid=19910308&doi=10.1093/bioinformatics/btp616&'s revenue stream
- How much money does https://doi.org/10.1186/gb-2010-11-3-r25 make?
- How much does https://scholar.google.com/scholar_lookup?journal=Genome%20Biol&title=A%20scaling%20normalization%20method%20for%20differential%20expression%20analysis%20of%20RNA-seq%20data&author=MD%20Robinson&author=A%20Oshlack&volume=11&issue=3&publication_year=2010&pages=R25&pmid=20196867&doi=10.1186/gb-2010-11-3-r25& net monthly?
- How much revenue does https://doi.org/10.1093/nar/gkp464 generate?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=Pscan:%20finding%20over-represented%20transcription%20factor%20binding%20site%20motifs%20in%20sequences%20from%20co-regulated%20or%20co-expressed%20genes&author=F%20Zambelli&author=G%20Pesole&author=G%20Pavesi&volume=37&issue=Web%20Server%20issue&publication_year=2009&pages=W247-W252&pmid=19487240&doi=10.1093/nar/gkp464&?
- How much profit does https://doi.org/10.1093/nar/gkx1126 generate?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=JASPAR%202018:%20update%20of%20the%20open-access%20database%20of%20transcription%20factor%20binding%20profiles%20and%20its%20web%20framework&author=A%20Khan&volume=46&issue=D1&publication_year=2018&pages=D260-D266&pmid=29140473&doi=10.1093/nar/gkx1126&
- How much income does https://doi.org/10.1093/biostatistics/4.2.249 have?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Biostatistics&title=Exploration,%20normalization,%20and%20summaries%20of%20high%20density%20oligonucleotide%20array%20probe%20level%20data&author=RA%20Irizarry&volume=4&issue=2&publication_year=2003&pages=249-264&pmid=12925520&doi=10.1093/biostatistics/4.2.249&?
- What are the total earnings of https://doi.org/10.1093/nar/gkv007?
- How much does https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=limma%20powers%20differential%20expression%20analyses%20for%20RNA-sequencing%20and%20microarray%20studies&author=ME%20Ritchie&volume=43&issue=7&publication_year=2015&pages=e47&pmid=25605792&doi=10.1093/nar/gkv007& pull in monthly?
- https://doi.org/10.1093/bioinformatics/bty648's financial summary
- Revenue of https://scholar.google.com/scholar_lookup?journal=Bioinformatics&title=Scaling%20read%20aligners%20to%20hundreds%20of%20threads%20on%20general-purpose%20processors&author=B%20Langmead&author=C%20Wilks&author=V%20Antonescu&author=R%20Charles&volume=35&issue=3&publication_year=2019&pages=421-432&pmid=30020410&doi=10.1093/bioinformatics/bty648&
- How much does https://doi.org/10.1093/bioinformatics/btp352 net monthly?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Bioinformatics&title=The%20Sequence%20Alignment/Map%20format%20and%20SAMtools&author=H%20Li&volume=25&issue=16&publication_year=2009&pages=2078-2079&pmid=19505943&doi=10.1093/bioinformatics/btp352& generate?
- Revenue of https://doi.org/10.1038/nbt.1754
- How much does https://scholar.google.com/scholar_lookup?journal=Nat%20Biotechnol&title=Integrative%20genomics%20viewer&author=JT%20Robinson&volume=29&issue=1&publication_year=2011&pages=24-26&pmid=21221095&doi=10.1038/nbt.1754& net monthly?
- Financial intake of https://doi.org/10.1093/nar/gkw257
- How much does https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=deepTools2:%20a%20next%20generation%20web%20server%20for%20deep-sequencing%20data%20analysis&author=F%20Ram%C3%ADrez&volume=44&issue=W1&publication_year=2016&pages=W160-W165&pmid=27079975&doi=10.1093/nar/gkw257& net monthly?
- Learn about the earnings of https://doi.org/10.1186/gb-2008-9-9-r137
- https://scholar.google.com/scholar_lookup?journal=Genome%20Biol&title=Model-based%20analysis%20of%20ChIP-Seq%20(MACS)&author=Y%20Zhang&volume=9&issue=9&publication_year=2008&pages=R137&pmid=18798982&doi=10.1186/gb-2008-9-9-r137&'s total income per month
- How much income does https://doi.org/10.1093/bioinformatics/btv145 have?
- How much does https://scholar.google.com/scholar_lookup?journal=Bioinformatics&title=ChIPseeker:%20an%20R/Bioconductor%20package%20for%20ChIP%20peak%20annotation,%20comparison%20and%20visualization&author=G%20Yu&author=LG%20Wang&author=QY%20He&volume=31&issue=14&publication_year=2015&pages=2382-2383&pmid=25765347&doi=10.1093/bioinformatics/btv145& generate monthly?
- Revenue of https://doi.org/10.1186/1471-2105-14-7
- How much does https://scholar.google.com/scholar_lookup?journal=BMC%20Bioinformatics&title=GSVA:%20gene%20set%20variation%20analysis%20for%20microarray%20and%20RNA-seq%20data&author=S%20H%C3%A4nzelmann&author=R%20Castelo&author=J%20Guinney&volume=14&publication_year=2013&pages=7&pmid=23323831&doi=10.1186/1471-2105-14-7& generate monthly?
- How profitable is https://github.com/ncbi?
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- What's the financial gain of https://www.nlm.nih.gov/web_policies.html?
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- What are the earnings of https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- What's the income of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal?
- What's the financial gain of https://www.nlm.nih.gov/accessibility.html?
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- https://www.nlm.nih.gov/'s financial summary
- https://www.nih.gov/'s financial summary
- Profit of https://www.hhs.gov/
- How much does https://www.usa.gov/ rake in every month?
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