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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

doi, cancer, metabolic, google, scholar, pubmed, cells, pmc, article, free, tumors, tumor, cell, mutations, metabolism, nature, metastasis, lung, growth, metastatic, human, therapeutic, models, progression, pathways, kras, oncogenic, oxidative, expression, reprogramming, inhibitors, lesions, tissue, oxphos, primary, science, glutamine, phenotypes, cancers, clinical, including, heterogeneity, liabilities, fig, mice, enhanced, breast, properties, promote, studies,

Topics {✒️}

methyl-4-deoxy-4-[18f]-fluoro-α-d-glucopyranoside α-ketoglutarate-dependent enzyme prolyl-4-hydroxylase glutamine analog 6-diazo-5-oxo-l-norleucine inhibit α-ketoglutarate-dependent enzymes homologous-recombination dna repair magnetic resonance spectroscopy targeting metastasis-initiating cells pdac-induced macrophage polarization stimulates collagen cross-linking pmc beta search inhibit vhl-dependent degradation excessive collagen cross-linking serine-threonine kinase lkb1 hypoxia-inducible factor-α triple-negative breast cancer fatty acid oxidation regenerate ros-detoxifying metabolites tumor-induced gene expression mct1-dependent lactate transport additional subtype-selective metabolic renal cell carcinoma sporadic tp53-mutant cancers lkb1-mutant lung cancer cultured cancer cells–notably kras-mutant lung adenocarcinoma small-cell lung cancers growth-promoting metabolic network primary invasive cancers acquire cell-autonomous properties locally invasive cancers d-2hg inhibits enzymes patient-derived melanoma xenografts lymph node metastases early-stage lung adenocarcinoma patient-specific tumor metabolism small-cell lung cancer combinatorial cell-intrinsic effects cell-autonomous adaptive resistance low-glucose conditions selects impair hematopoietic differentiation premalignant lesions relative oncogene-dependent activation invasive cancer cells targetable metabolic vulnerability kras-stk11 metabolic phenotype cell-autonomous metabolic effects locally invasive tumors oncogene-driven liabilities acute myelogenous leukemia low genomic burden

Questions {❓}

• How then should we prioritize potential metabolic liabilities for further study and the development of new therapies?
• Is the therapeutic window for OXPHOS inhibitors wide enough, given that this pathway is so important in many other tissues?

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• Earnings of https://doi.org/10.1158/2159-8290.CD-14-1236
• How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Discov&title=Co-occurring%20genomic%20alterations%20define%20major%20subsets%20of%20KRAS-mutant%20lung%20adenocarcinoma%20with%20distinct%20biology,%20immune%20profiles,%20and%20therapeutic%20vulnerabilities&author=F%20Skoulidis&volume=5&publication_year=2015&pages=860-877&pmid=26069186&doi=10.1158/2159-8290.CD-14-1236& generate monthly?
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• https://doi.org/10.1038/nature20132's financial summary
• Profit of https://scholar.google.com/scholar_lookup?journal=Nature&title=LKB1%20loss%20links%20serine%20metabolism%20to%20DNA%20methylation%20and%20tumorigenesis&author=F%20Kottakis&volume=539&publication_year=2016&pages=390-395&pmid=27799657&doi=10.1038/nature20132&
• What are the total earnings of https://doi.org/10.1158/0008-5472.CAN-14-2211?
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• How much does https://doi.org/10.1038/nature07823 gross monthly?
• How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=c-Myc%20suppression%20of%20miR-23a/b%20enhances%20mitochondrial%20glutaminase%20expression%20and%20glutamine%20metabolism&author=P%20Gao&volume=458&publication_year=2009&pages=762-765&pmid=19219026&doi=10.1038/nature07823& gross monthly?
• Discover the revenue of https://doi.org/10.1038/nature12138
• https://scholar.google.com/scholar_lookup?journal=Nature&title=Macropinocytosis%20of%20protein%20is%20an%20amino%20acid%20supply%20route%20in%20Ras-transformed%20cells&author=C%20Commisso&volume=497&publication_year=2013&pages=633-637&pmid=23665962&doi=10.1038/nature12138& income
• What are the total earnings of https://doi.org/10.1158/2159-8290.CD-17-1215?
• https://scholar.google.com/scholar_lookup?journal=Cancer%20Discov&title=PTEN%20deficiency%20and%20AMPK%20activation%20promote%20nutrient%20scavenging%20and%20anabolism%20in%20prostate%20cancer%20cells&author=SM%20Kim&volume=8&publication_year=2018&pages=866-883&pmid=29572236&doi=10.1158/2159-8290.CD-17-1215&'s total income per month
• How profitable is https://doi.org/10.1126/science.aar2663?
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• What's the financial gain of https://doi.org/10.1016/j.cell.2017.09.019?
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• What's the financial intake of https://doi.org/10.1016/j.cell.2015.12.034?
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Cell&title=Metabolic%20heterogeneity%20in%20human%20lung%20tumors&author=CT%20Hensley&volume=164&publication_year=2016&pages=681-694&pmid=26853473&doi=10.1016/j.cell.2015.12.034&?
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• What are the earnings of https://doi.org/10.1038/nm.3391?
• What's https://scholar.google.com/scholar_lookup?journal=Nat.%20Med&title=Tumor%20metastasis:%20Moving%20new%20biological%20insights%20into%20the%20clinic&author=L%20Wan&author=K%20Pantel&author=Y%20Kang&volume=19&publication_year=2013&pages=1450-1464&pmid=24202397&doi=10.1038/nm.3391&'s gross income?
• How much does https://doi.org/10.5858/2008-132-931-MPOCRF pull in monthly?
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• What's the monthly money flow for https://doi.org/10.1200/JCO.2008.16.3543?
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• What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Clin.%20Cancer%20Res&title=Acid%20production%20in%20glycolysis-impaired%20tumors%20provides%20new%20insights%20into%20tumor%20metabolism&author=G%20Helmlinger&author=A%20Sckell&author=M%20Dellian&author=NS%20Forbes&author=RK%20Jain&volume=8&publication_year=2002&pages=1284-1291&pmid=11948144&?
• What's the monthly money flow for https://doi.org/10.1038/s41586-019-1340-y?
• Explore the financials of https://scholar.google.com/scholar_lookup?journal=Nature&title=UDP-glucose%20accelerates%20SNAI1%20mRNA%20decay%20and%20impairs%20lung%20cancer%20metastasis&author=X%20Wang&volume=571&publication_year=2019&pages=127-131&pmid=31243371&doi=10.1038/s41586-019-1340-y&
• What's the profit of https://doi.org/10.1038/nature25465?
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• What are the earnings of https://doi.org/10.1172/JCI67230?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Invest&title=HIF-1%20mediates%20metabolic%20responses%20to%20intratumoral%20hypoxia%20and%20oncogenic%20mutations&author=GL%20Semenza&volume=123&publication_year=2013&pages=3664-3671&pmid=23999440&doi=10.1172/JCI67230& generate?
• Find out how much https://doi.org/10.1038/onc.2011.365 earns monthly
• How profitable is https://scholar.google.com/scholar_lookup?journal=Oncogene&title=HIF-1-dependent%20expression%20of%20angiopoietin-like%204%20and%20L1CAM%20mediates%20vascular%20metastasis%20of%20hypoxic%20breast%20cancer%20cells%20to%20the%20lungs&author=H%20Zhang&volume=31&publication_year=2012&pages=1757-1770&pmid=21860410&doi=10.1038/onc.2011.365&?
• What's the income of https://doi.org/10.1016/j.cmet.2017.06.016?
• Earnings of https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=Metabolic%20regulation%20of%20T%20cell%20longevity%20and%20function%20in%20tumor%20immunotherapy&author=RJ%20Kishton&author=M%20Sukumar&author=NP%20Restifo&volume=26&publication_year=2017&pages=94-109&pmid=28683298&doi=10.1016/j.cmet.2017.06.016&
• What's the total monthly financial gain of https://doi.org/10.1016/S0002-9440(10)65628-3?
• https://scholar.google.com/scholar_lookup?journal=Am.%20J.%20Pathol&title=Multistep%20nature%20of%20metastatic%20inefficiency:%20Dormancy%20of%20solitary%20cells%20after%20successful%20extravasation%20and%20limited%20survival%20of%20early%20micrometastases&author=KJ%20Luzzi&volume=153&publication_year=1998&pages=865-873&pmid=9736035&doi=10.1016/S0002-9440(10)65628-3&'s revenue stream
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• What's the income of https://scholar.google.com/scholar_lookup?journal=Nature&title=Isolation%20of%20rare%20circulating%20tumour%20cells%20in%20cancer%20patients%20by%20microchip%20technology&author=S%20Nagrath&volume=450&publication_year=2007&pages=1235-1239&pmid=18097410&doi=10.1038/nature06385&?
• How much profit is https://doi.org/10.1126/scitranslmed.3000403 making per month?
• What's the profit of https://scholar.google.com/scholar_lookup?journal=Sci.%20Transl.%20Med&title=Isolation%20and%20characterization%20of%20circulating%20tumor%20cells%20from%20patients%20with%20localized%20and%20metastatic%20prostate%20cancer&author=SL%20Stott&volume=2&publication_year=2010&pages=25ra23&pmid=20424012&doi=10.1126/scitranslmed.3000403&?
• Revenue of https://doi.org/10.1038/nature08268
• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Nature&title=Antioxidant%20and%20oncogene%20rescue%20of%20metabolic%20defects%20caused%20by%20loss%20of%20matrix%20attachment&author=ZT%20Schafer&volume=461&publication_year=2009&pages=109-113&pmid=19693011&doi=10.1038/nature08268&?
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• How much does https://scholar.google.com/scholar_lookup?journal=Sci.%20Transl.%20Med&title=Antioxidants%20can%20increase%20melanoma%20metastasis%20in%20mice&author=K%20Le%20Gal&volume=7&publication_year=2015&pages=308re8&pmid=26446958&doi=10.1126/scitranslmed.aad3740& earn?
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• Check the income stats for https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol&title=PGC-1a%20mediates%20mitochondrial%20biogenesis%20and%20oxidative%20phosphorylation%20in%20cancer%20cells%20to%20promote%20metastasis&author=VS%20LeBleu&volume=16&publication_year=2014&pages=992-1003&pmid=25241037&doi=10.1038/ncb3039&
• Learn about the earnings of https://doi.org/10.1016/j.cell.2019.06.005
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Cell&title=BACH1%20stabilization%20by%20antioxidants%20stimulates%20lung%20cancer%20metastasis&author=C%20Wiel&volume=178&publication_year=2019&pages=330-345.e22&pmid=31257027&doi=10.1016/j.cell.2019.06.005& produce monthly?
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• How profitable is https://scholar.google.com/scholar_lookup?journal=Sci.%20Transl.%20Med&title=Antioxidants%20accelerate%20lung%20cancer%20progression%20in%20mice&author=VI%20Sayin&volume=6&publication_year=2014&pages=221ra15&pmid=24477002&doi=10.1126/scitranslmed.3007653&?
• Explore the financials of https://doi.org/10.1016/j.cell.2019.06.003
• How much profit is https://scholar.google.com/scholar_lookup?journal=Cell&title=Nrf2%20activation%20promotes%20lung%20cancer%20metastasis%20by%20inhibiting%20the%20degradation%20of%20Bach1&author=L%20Lignitto&volume=178&publication_year=2019&pages=316-329&pmid=31257023&doi=10.1016/j.cell.2019.06.003& making per month?
• Discover the revenue of https://doi.org/10.1126/science.1156906
• How much income does https://scholar.google.com/scholar_lookup?journal=Science&title=ROS-generating%20mitochondrial%20DNA%20mutations%20can%20regulate%20tumor%20cell%20metastasis&author=K%20Ishikawa&volume=320&publication_year=2008&pages=661-664&pmid=18388260&doi=10.1126/science.1156906& have?
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• How profitable is https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Pro-metastatic%20signaling%20by%20c-Met%20through%20RAC-1%20and%20reactive%20oxygen%20species%20(ROS)&author=D%20Ferraro&volume=25&publication_year=2006&pages=3689-3698&pmid=16462764&doi=10.1038/sj.onc.1209409&?
• How much does https://doi.org/10.1016/j.celrep.2014.06.043 net monthly?
• What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=A%20mitochondrial%20switch%20promotes%20tumor%20metastasis&author=PE%20Porporato&volume=8&publication_year=2014&pages=754-766&pmid=25066121&doi=10.1016/j.celrep.2014.06.043&?
• Learn about the earnings of https://doi.org/10.1146/annurev-cancerbio-041916-065808
• Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Ann.%20Rev.%20Cancer%20Biol&title=The%20two%20faces%20of%20reactive%20oxygen%20species%20in%20cancer&author=CR%20Reczek&author=NS%20Chandel&volume=1&publication_year=2017&pages=79-98&doi=10.1146/annurev-cancerbio-041916-065808&
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Apoptosis:%20An%20early%20event%20in%20metastatic%20inefficiency&author=CW%20Wong&volume=61&publication_year=2001&pages=333-338&pmid=11196183&?
• Monthly income for https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Temporal%20progression%20of%20metastasis%20in%20lung:%20Cell%20survival,%20dormancy,%20and%20location%20dependence%20of%20metastatic%20inefficiency&author=MD%20Cameron&volume=60&publication_year=2000&pages=2541-2546&pmid=10811137&
• What is the earnings of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Activated%20ras%20regulates%20the%20proliferation/apoptosis%20balance%20and%20early%20survival%20of%20developing%20micrometastases&author=HJ%20Varghese&volume=62&publication_year=2002&pages=887-891&pmid=11830548&?
• What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Persistence%20of%20solitary%20mammary%20carcinoma%20cells%20in%20a%20secondary%20site:%20A%20possible%20contributor%20to%20dormancy&author=GN%20Naumov&volume=62&publication_year=2002&pages=2162-2168&pmid=11929839&?
• How much money does https://doi.org/10.1016/j.ccr.2013.09.007 generate?
• Income figures for https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Origins%20of%20metastatic%20traits&author=S%20Vanharanta&author=J%20Massague&volume=24&publication_year=2013&pages=410-421&pmid=24135279&doi=10.1016/j.ccr.2013.09.007&
• How much does https://doi.org/10.1038/nature17038 pull in?
• Income figures for https://scholar.google.com/scholar_lookup?journal=Nature&title=Metastatic%20colonization%20by%20circulating%20tumour%20cells&author=J%20Massague&author=AC%20Obenauf&volume=529&publication_year=2016&pages=298-306&pmid=26791720&doi=10.1038/nature17038&
• Profit of https://doi.org/10.18632/oncotarget.2677
• How much does https://scholar.google.com/scholar_lookup?journal=Oncotarget&title=The%20landscape%20of%20metastatic%20progression%20patterns%20across%20major%20human%20cancers&author=J%20Budczies&volume=6&publication_year=2015&pages=570-583&pmid=25402435&doi=10.18632/oncotarget.2677& pull in monthly?
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• How much money does https://scholar.google.com/scholar_lookup?journal=Nature&title=Breast%20cancer%20cells%20rely%20on%20environmental%20pyruvate%20to%20shape%20the%20metastatic%20niche&author=I%20Elia&volume=568&publication_year=2019&pages=117-121&pmid=30814728&doi=10.1038/s41586-019-0977-x& make?
• Earnings of https://doi.org/10.1038/nm.2492
• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Nat.%20Med&title=Adipocytes%20promote%20ovarian%20cancer%20metastasis%20and%20provide%20energy%20for%20rapid%20tumor%20growth&author=KM%20Nieman&volume=17&publication_year=2011&pages=1498-1503&pmid=22037646&doi=10.1038/nm.2492&?
• How much does https://doi.org/10.1126/science.aav0173 bring in each month?
• Financial intake of https://scholar.google.com/scholar_lookup?journal=Science&title=Tumor%20metastasis%20to%20lymph%20nodes%20requires%20YAP-dependent%20metabolic%20adaptation&author=CK%20Lee&volume=363&publication_year=2019&pages=644-649&pmid=30733421&doi=10.1126/science.aav0173&
• How much profit is https://doi.org/10.1016/j.celrep.2016.02.004 making per month?
• How much does https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=Fatty%20acid%20oxidation-driven%20Src%20links%20mitochondrial%20energy%20reprogramming%20and%20oncogenic%20properties%20in%20triple-negative%20breast%20cancer&author=JH%20Park&volume=14&publication_year=2016&pages=2154-2165&pmid=26923594&doi=10.1016/j.celrep.2016.02.004& pull in monthly?
• Check the income stats for https://doi.org/10.1038/nature20791
• How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Targeting%20metastasis-initiating%20cells%20through%20the%20fatty%20acid%20receptor%20CD36&author=G%20Pascual&volume=541&publication_year=2017&pages=41-45&pmid=27974793&doi=10.1038/nature20791& gross monthly?
• Learn about the earnings of https://doi.org/10.1016/j.cmet.2015.08.007
• Explore the financials of https://scholar.google.com/scholar_lookup?journal=Cell%20Metab&title=PDK1-dependent%20metabolic%20reprogramming%20dictates%20metastatic%20potential%20in%20breast%20cancer&author=F%20Dupuy&volume=22&publication_year=2015&pages=577-589&pmid=26365179&doi=10.1016/j.cmet.2015.08.007&
• How much does https://doi.org/10.1158/2159-8290.CD-18-1489 generate monthly?
• How much cash flow does https://scholar.google.com/scholar_lookup?journal=Cancer%20Discov&title=Molecular%20profiling%20reveals%20unique%20immune%20and%20metabolic%20features%20of%20melanoma%20brain%20metastases&author=GM%20Fischer&volume=9&publication_year=2019&pages=628-645&pmid=30787016&doi=10.1158/2159-8290.CD-18-1489& have monthly?
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• How much revenue does https://scholar.google.com/scholar_lookup?journal=Nature&title=Metabolic%20heterogeneity%20confers%20differences%20in%20melanoma%20metastatic%20potential&author=A%20Tasdogan&volume=577&publication_year=2020&pages=115-120&pmid=31853067&doi=10.1038/s41586-019-1847-2& bring in?
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• How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Oncogene%20ablation-resistant%20pancreatic%20cancer%20cells%20depend%20on%20mitochondrial%20function&author=A%20Viale&volume=514&publication_year=2014&pages=628-632&pmid=25119024&doi=10.1038/nature13611& pull in?
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• https://scholar.google.com/scholar_lookup?journal=Nature&title=IDH%20mutation%20impairs%20histone%20demethylation%20and%20results%20in%20a%20block%20to%20cell%20differentiation&author=C%20Lu&volume=483&publication_year=2012&pages=474-478&pmid=22343901&doi=10.1038/nature10860&'s revenue stream
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• What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Cell&title=Transaminase%20inhibition%20by%202-hydroxyglutarate%20impairs%20glutamate%20biosynthesis%20and%20redox%20homeostasis%20in%20glioma&author=SK%20McBrayer&volume=175&publication_year=2018&pages=101-116.e25&pmid=30220459&doi=10.1016/j.cell.2018.08.038&?
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• What are the earnings of https://doi.org/10.1038/ncomms9784?
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• https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=A%20role%20for%20cytosolic%20fumarate%20hydratase%20in%20urea%20cycle%20metabolism%20and%20renal%20neoplasia&author=J%20Adam&volume=3&publication_year=2013&pages=1440-1448&pmid=23643539&doi=10.1016/j.celrep.2013.04.006&'s revenue stream
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• https://doi.org/10.1016/j.ccell.2019.08.005's total income per month
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• What's https://scholar.google.com/scholar_lookup?journal=Nat.%20Med&title=An%20inhibitor%20of%20oxidative%20phosphorylation%20exploits%20cancer%20vulnerability&author=JR%20Molina&volume=24&publication_year=2018&pages=1036-1046&pmid=29892070&doi=10.1038/s41591-018-0052-4&'s gross income?
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• What's the income generated by https://doi.org/10.1146/annurev-cancerbio-050216-121954 each month?
• How much profit is https://scholar.google.com/scholar_lookup?journal=Ann.%20Rev.%20Cancer%20Biol&title=Analyzing%20tumor%20metabolism%20in%20vivo&author=B%20Faubert&author=RJ%20DeBerardinis&volume=1&publication_year=2016&pages=99-117&doi=10.1146/annurev-cancerbio-050216-121954& making per month?
• https://doi.org/10.1200/JCO.2016.67.1222 income
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• What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Sci.%20Transl.%20Med&title=Metabolic%20imaging%20of%20patients%20with%20prostate%20cancer%20using%20hyperpolarized%20%5B1-13C%5Dpyruvate&author=SJ%20Nelson&volume=5&publication_year=2013&pages=198ra108&pmid=23946197&doi=10.1126/scitranslmed.3006070&?
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• What's https://www.nih.gov/'s gross income?
• https://www.hhs.gov/ income
• Earnings of https://www.usa.gov/

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