
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Unfolded protein response mediator PERK governs myeloid cell-driven immunosuppression in tumors through inhibition of STING signaling - PMC
Description:
The primary mechanisms supporting the immunoregulatory polarization of myeloid cells upon infiltration into tumors remain largely unexplored. Elucidation of these signals could enable better strategies to restore protective anti-tumor immunity. ...
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Keywords {🔍}
mice, cells, figure, cat, mdsc, cell, perk, tumormdsc, tumor, tumors, doi, pubmed, google, scholar, pmc, article, eifakflfllyzcre, free, nrf, treated, antimouse, cancer, bmmdsc, signaling, activity, antitumor, compared, expression, immunity, proliferation, sting, eifakflfl, activation, mitochondrial, llc, control, myeloid, deletion, type, upr, effects, growth, tudca, stress, hours, controls, thaps, eifak, role, cytosolic,
Topics {✒️}
recombinant dna pcdh-mscv-mcs-ef1α-gfp lentiviral vector pcdh-mscv-mcs-ef1α-gfp eif2ak3fl/fland eif2ak3fl/fllyz2-cre mice pan02-ova-zsgreen-bearing eif2ak3fl/fl lsl-krasg12d/+trp53−/− mice reconstituted egsrnqdwl-h-2db-tetramer+cd8+ lsl-krasg12d/+trp53fl/fl mice llc-bearing eif2ak3fl/fllyz2-cre mice eif2ak3fl/fl tmem173 fl/fllyz2-cre egsrnqdwl-h-2db tetramer+ pan02-ova-zsgreen-bearing mice phiv-t2a-zsgreen vector backbone lsl-krasg12d/+trp53fl/fl siinfekl-h-2kb-tetramer+ eif2ak3fl/fltmem173fl/fllyz2-cre mice llc-bearing eif2ak3fl/fllyz2-cre pan-cytokeratinnegcd11b+hla-drnegcd14+cd15neg pan02-ova-zsgreen cells lines goat anti-mouse igg id8-defb29-vegfa ovarian tumors eif2ak3fl/fllyz2-cre mice relative eif2ak3fl/fllyz2-cre mice treated mitochondrial-free cytosolic extracts eif2ak3fl/fllyz2-cre mice compared tdtomatofl/+tek-cre reporter mice activates anti-tumor immunity il-4-derived bm-dcs loaded ova-bound h-2kb siinfekl-bound h-2kb recently activated cd69+cd44+cd8+ specific pathogen-free conditions cd11b+gr1+ly6g+ly6clow full-length ddit3 cdna anti-pd-l1 therapy elicited anti-tumor responses pan02-ova-zsgreen tumors 250 μg anti-pd-l1 eif2ak3fl/fltmem173fl/fllyz2-cre cell-trace violet-labeled ot ovarian id8-defb29-vegfa perk-deficient tumor-mdsc pulsed mitochondria-free cytosolic fractions eif2ak3−/−bm-mdsc pre-treated eif2ak3−/− bm-mdsc pre-treated bone marrow-derived mdsc recently primed cd69+cd44+cd8+ perk-null bm-mdsc treated anti-tumor immune evasion eif2ak3fl/fllyz2-cre mice anti-cd11b-biotinylated antibodies
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