
NCBI . NLM . NIH . GOV {
}
Title[redir]:
CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling - PMC
Description:
Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer type. CPI-613 (Devimistat), a novel ...
Matching Content Categories {π}
- Science
- Health & Fitness
- Education
Content Management System {π}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of ncbi.nlm.nih.gov audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Ncbi.nlm.nih.gov Make Money? {πΈ}
We donβt know how the website earns money.
Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Ncbi.nlm.nih.gov might have a hidden revenue stream, but it's not something we can detect.
Keywords {π}
cpi, cells, cancer, apoptosis, pancreatic, doi, fig, cell, aspc, panc, treated, autophagy, lipid, metabolism, treatment, pubmed, google, scholar, signaling, cpiinduced, pmc, ampk, acc, effects, determined, free, data, levels, article, mitochondrial, staining, viability, patients, acid, study, ros, analysis, ampkacc, fatty, western, blot, presence, kit, flow, cytometry, results, antibody, absence, increased, culture,
Topics {βοΈ}
fatty acid synthase 7β²-dichlorofluorescin diacetate sodium cacodylate annexin v-fitc/pi staining alpha-ketoglutarate dehydrogenase n-acetylcysteine transmission electron microscopy mitochondrial tricarboxylic acid transfected mrfp-gfp-lc3b plasmid free fatty acids tumor-specific anti-mitochondrial agent p-acetyl-coa carboxylase nab-paclitaxel fatty acid synthesis mrfp-gfp-lc3b plasmid small-cell lung cancer mrfp-gfp-lc3b dots grb2-mediated egfr downregulation tca cycle-mediated generation acetyl-coa carboxylase fgf19/fgfr4 signaling contributes autocrine fgf19/fgfr4 signaling fgfr4βgsk3Ξ²βnrf2 signaling dcfh-da fluorescent dye cell proliferation dose-dependently pmc beta search lc3b-positive puncta compared decreasing autophagosome-lysosome fusion methods cell lines acc inhibitor tofa ampk-acc signaling contributes reduced ffa levels ampk-acc signaling axis electron microscopy pmc copyright notice 550βnm excitation/600βnm emission 485βnm excitation/535βnm emission modified folfirinox human pancreatic cancer ampk-dependent acc inhibition mrfp-gfp-lc3b ampk-dependent autophagic signaling Ξ±-kgdh released ffa levels alleviating cpi-613-induced apoptosis disrupt mitochondrial structure fatty acids p-atp-citrate lyase fatty acid cpi-613-induced ros generation
Questions {β}
- Friend or foe?
Social Networks {π}(6)
External Links {π}(73)
- What's the revenue for https://doi.org/10.1186/s13046-020-01579-x?
- What's the financial intake of http://creativecommons.org/licenses/by/4.0/?
- What's the income of http://creativecommons.org/publicdomain/zero/1.0/?
- How much does https://doi.org/10.3322/caac.21338 pull in monthly?
- https://scholar.google.com/scholar_lookup?journal=CA%20Cancer%20J%20Clin&title=Cancer%20statistics%20in%20China,%202015&author=W%20Chen&author=R%20Zheng&author=PD%20Baade&author=S%20Zhang&author=H%20Zeng&volume=66&issue=2&publication_year=2016&pages=115-132&pmid=26808342&doi=10.3322/caac.21338& income
- Find out how much https://doi.org/10.3322/caac.21387 earns monthly
- See how much https://scholar.google.com/scholar_lookup?journal=CA%20Cancer%20J%20Clin&title=Cancer%20statistics,%202017&author=R%20Siegiel&author=K%20Miller&author=A%20Jemal&volume=67&publication_year=2017&pages=7-30&pmid=28055103&doi=10.3322/caac.21387& makes per month
- How much does https://doi.org/10.1038/srep06747 gross monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=Sci%20Rep&title=Survival%20improvement%20in%20patients%20with%20pancreatic%20cancer%20by%20decade:%20a%20period%20analysis%20of%20the%20SEER%20database,%201981-2010&author=H%20Sun&author=H%20Ma&author=G%20Hong&author=H%20Sun&author=J%20Wang&volume=4&publication_year=2014&pages=6747&pmid=25339498&doi=10.1038/srep06747& earn?
- https://doi.org/10.1038/ncomms8686 income
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Nat%20Commun&title=Clinical%20implications%20of%20genomic%20alterations%20in%20the%20tumour%20and%20circulation%20of%20pancreatic%20cancer%20patients&author=M%20Sausen&author=J%20Phallen&author=V%20Adleff&author=S%20Jones&author=RJ%20Leary&volume=6&publication_year=2015&pages=7686&pmid=26154128&doi=10.1038/ncomms8686&?
- Explore the financials of https://doi.org/10.1245/s10434-014-3898-9
- See how much https://scholar.google.com/scholar_lookup?journal=Ann%20Surg%20Oncol&title=FOLFIRINOX%20for%20locally%20advanced%20pancreatic%20adenocarcinoma:%20results%20of%20an%20AGEO%20multicenter%20prospective%20observational%20cohort&author=L%20Marthey&author=A%20Sa-Cunha&author=J%20Blanc&author=M%20Gauthier&author=A%20Cueff&volume=22&issue=1&publication_year=2015&pages=295-301&pmid=25037971&doi=10.1245/s10434-014-3898-9& makes per month
- Learn about the earnings of https://doi.org/10.3747/co.26.4903
- https://scholar.google.com/scholar_lookup?journal=Curr%20Oncol&title=FOLFIRINOX%20in%20patients%20with%20peritoneal%20carcinomatosis%20from%20pancreatic%20adenocarcinoma:%20a%20retrospective%20study&author=E%20Bonnet&author=C%20Mastier&author=A%20Lardy-Cl%C3%A9aud&author=P%20Rochefort&author=M%20Sarabi&volume=26&issue=4&publication_year=2019&pages=e466-e472&pmid=31548814&doi=10.3747/co.26.4903&'s total income per month
- How much does https://doi.org/10.1007/s10495-005-0810-x rake in every month?
- How much does https://scholar.google.com/scholar_lookup?journal=Apoptosis&title=%CE%B1-Lipoic%20acid%20induces%20apoptosis%20in%20human%20colon%20cancer%20cells%20by%20increasing%20mitochondrial%20respiration%20with%20a%20concomitant%20O2%E2%88%92.-generation&author=U%20Wenzel&author=A%20Nickel&author=H%20Daniel&volume=10&issue=2&publication_year=2005&pages=359-368&pmid=15843897&doi=10.1007/s10495-005-0810-x& make?
- Earnings of https://doi.org/10.1016/j.bbrc.2017.10.030
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Biochem%20Biophys%20Res%20Commun&title=%CE%B1-Lipoic%20acid%20inhibits%20human%20lung%20cancer%20cell%20proliferation%20through%20Grb2-mediated%20EGFR%20downregulation&author=L%20Yang&author=Y%20Wen&author=G%20Lv&author=Y%20Lin&author=J%20Tang&volume=494&issue=1%E2%80%932&publication_year=2017&pages=325-331&pmid=28993193&doi=10.1016/j.bbrc.2017.10.030&?
- Earnings of https://doi.org/10.1007/s00109-011-0785-8
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=J%20Mol%20Med&title=Non-redox-active%20lipoate%20derivates%20disrupt%20cancer%20cell%20mitochondrial%20metabolism%20and%20are%20potent%20anticancer%20agents%20in%20vivo&author=Z%20Zachar&author=J%20Marecek&author=C%20Maturo&author=S%20Gupta&author=SD%20Stuart&volume=89&issue=11&publication_year=2011&pages=1137-1148&pmid=21769686&doi=10.1007/s00109-011-0785-8&?
- What are the earnings of https://doi.org/10.1016/S1470-2045(17)30314-5?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Lancet%20Oncol&title=Safety%20and%20tolerability%20of%20the%20first-in-class%20agent%20CPI-613%20in%20combination%20with%20modified%20FOLFIRINOX%20in%20patients%20with%20metastatic%20pancreatic%20cancer:%20a%20single-Centre,%20open-label,%20dose-escalation,%20phase%201%20trial&author=A%20Alistar&author=BB%20Morris&author=R%20Desnoyer&author=HD%20Klepin&author=K%20Hosseinzadeh&volume=18&issue=6&publication_year=2017&pages=770-778&pmid=28495639&doi=10.1016/S1470-2045(17)30314-5& each month?
- What's the financial intake of https://doi.org/10.1186/2049-3002-2-4?
- https://scholar.google.com/scholar_lookup?journal=Cancer%20Metab&title=A%20strategically%20designed%20small%20molecule%20attacks%20alpha-ketoglutarate%20dehydrogenase%20in%20tumor%20cells%20through%20a%20redox%20process&author=SD%20Stuart&author=A%20Schauble&author=S%20Gupta&author=AD%20Kennedy&author=BR%20Keppler&volume=2&issue=1&publication_year=2014&pages=4&pmid=24612826&doi=10.1186/2049-3002-2-4&'s revenue stream
- Monthly income for https://doi.org/10.3390/cancers11111678
- How much income does https://scholar.google.com/scholar_lookup?journal=Cancers.&title=The%20metabolic%20inhibitor%20CPI-613%20negates%20treatment%20enrichment%20of%20ovarian%20Cancer%20stem%20cells&author=C%20Bellio&author=C%20DiGloria&author=DR%20Spriggs&author=R%20Foster&author=WB%20Growdon&volume=11&issue=11&publication_year=2019&pages=1678&pmid=31671803&doi=10.3390/cancers11111678& have?
- Profit of https://doi.org/10.3978/j.issn.2305-5839.2014.05.08
- How much does https://scholar.google.com/scholar_lookup?journal=Ann%20Transl%20Med&title=Translational%20assessment%20of%20mitochondrial%20dysfunction%20of%20pancreatic%20cancer%20from%20in%20vitro%20gene%20microarray%20and%20animal%20efficacy%20studies,%20to%20early%20clinical%20studies,%20via%20the%20novel%20tumor-specific%20anti-mitochondrial%20agent,%20CPI-613&author=KC%20Lee&author=C%20Maturo&author=CN%20Perera&author=J%20Luddy&author=R%20Rodriguez&volume=2&issue=9&publication_year=2014&pages=91&pmid=25405166&doi=10.3978/j.issn.2305-5839.2014.05.08& net monthly?
- Get to know https://doi.org/10.2217/fon-2019-0209's earnings
- How much does https://scholar.google.com/scholar_lookup?journal=Future%20Oncol&title=A%20phase%20III%20open-label%20trial%20to%20evaluate%20efficacy%20and%20safety%20of%20CPI-613%20plus%20modified%20FOLFIRINOX%20(mFFX)%20versus%20FOLFIRINOX%20(FFX)%20in%20patients%20with%20metastatic%20adenocarcinoma%20of%20the%20pancreas&author=PA%20Philip&author=ME%20Buyse&author=AT%20Alistar&author=CM%20Lima&author=S%20Luther&volume=15&issue=28&publication_year=2019&pages=3189-3196&pmid=31512497&doi=10.2217/fon-2019-0209& make?
- How much cash flow does https://doi.org/10.1007/s00109-018-1670-5 have monthly?
- https://scholar.google.com/scholar_lookup?journal=J%20Mol%20Med&title=Autophagy%20blockade%20sensitizes%20human%20head%20and%20neck%20squamous%20cell%20carcinoma%20towards%20CYT997%20through%20enhancing%20excessively%20high%20reactive%20oxygen%20species-induced%20apoptosis&author=L%20Gao&author=X%20Zhao&author=L%20Lang&author=C%20Shay&author=WA%20Yeudall&volume=96&issue=9&publication_year=2018&pages=929-938&pmid=30022281&doi=10.1007/s00109-018-1670-5&'s total income per month
- Revenue of https://doi.org/10.1038/s41388-018-0591-7
- How much does https://scholar.google.com/scholar_lookup?journal=Oncogene.&title=FGF19%20amplification%20reveals%20an%20oncogenic%20dependency%20upon%20autocrine%20FGF19/FGFR4%20signaling%20in%20head%20and%20neck%20squamous%20cell%20carcinoma&author=L%20Gao&author=L%20Lang&author=X%20Zhao&author=C%20Shay&author=AY%20Shull&volume=38&issue=13&publication_year=2019&pages=2394-2404&pmid=30518874&doi=10.1038/s41388-018-0591-7& gross monthly?
- How much revenue does https://doi.org/10.1111/jcmm.14017 produce monthly?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cell%20Mol%20Med&title=Intracellular%20reduction%20in%20ATP%20levels%20contributes%20to%20CYT%20997-induced%20suppression%20of%20metastasis%20of%20head%20and%20neck%20squamous%20carcinoma&author=X%20Zhao&author=L%20Lang&author=L%20He&author=L%20Gao&author=D%20Chyan&volume=23&issue=2&publication_year=2019&pages=1174-1182&pmid=30450674&doi=10.1111/jcmm.14017&?
- How much does https://doi.org/10.1158/0008-5472.CAN-17-2039 bring in each month?
- How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=FGF19%20protects%20hepatocellular%20carcinoma%20cells%20against%20endoplasmic%20reticulum%20stress%20via%20activation%20of%20FGFR4%E2%80%93GSK3%CE%B2%E2%80%93Nrf2%20signaling&author=Y%20Teng&author=H%20Zhao&author=L%20Gao&author=W%20Zhang&author=AY%20Shull&volume=77&issue=22&publication_year=2017&pages=6215-6225&pmid=28951455&doi=10.1158/0008-5472.CAN-17-2039& pull in monthly?
- Learn about the earnings of https://doi.org/10.1186/s13046-016-0478-9
- Monthly income for https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Clin%20Cancer%20Res&title=FGF19/FGFR4%20signaling%20contributes%20to%20the%20resistance%20of%20hepatocellular%20carcinoma%20to%20sorafenib&author=L%20Gao&author=X%20Wang&author=Y%20Tang&author=S%20Huang&author=C%20Hu&volume=36&issue=1&publication_year=2017&pages=8&pmid=28069043&doi=10.1186/s13046-016-0478-9&
- How much income does https://doi.org/10.1186/s13045-019-0827-1 have?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=J%20Hematol%20Oncol&title=Simultaneously%20inactivating%20Src%20and%20AKT%20by%20saracatinib/capivasertib%20co-delivery%20nanoparticles%20to%20improve%20the%20efficacy%20of%20anti-Src%20therapy%20in%20head%20and%20neck%20squamous%20cell%20carcinoma&author=L%20Lang&author=C%20Shay&author=X%20Zhao&author=Y%20Xiong&author=X%20Wang&volume=12&issue=1&publication_year=2019&pages=132&pmid=31805962&doi=10.1186/s13045-019-0827-1&?
- Revenue of https://doi.org/10.4155/fmc-2017-0110
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=Future%20Med%20Chem&title=Friend%20or%20foe?%20Mitochondria%20as%20a%20pharmacological%20target%20in%20cancer%20treatment&author=T%20Dickerson&author=CE%20Jauregui&author=Y%20Teng&volume=9&issue=18&publication_year=2017&pages=2197-2210&pmid=29182013&doi=10.4155/fmc-2017-0110&
- How much profit does https://doi.org/10.4155/fmc-2016-0210 generate?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Future%20Med%20Chem&title=Targeting%20autophagy%20as%20a%20strategy%20for%20drug%20discovery%20and%20therapeutic%20modulation&author=L%20Gao&author=CE%20Jauregui&author=Y%20Teng&volume=9&issue=3&publication_year=2017&pages=335-345&pmid=28176543&doi=10.4155/fmc-2016-0210& bring in?
- See how much https://doi.org/10.1080/15548627.2018.1474314 makes per month
- https://scholar.google.com/scholar_lookup?journal=Autophagy&title=Chloroquine%20inhibits%20autophagic%20flux%20by%20decreasing%20autophagosome-lysosome%20fusion&author=M%20Mauthe&author=I%20Orhon&author=C%20Rocchi&author=X%20Zhou&author=M%20Luhr&volume=14&issue=8&publication_year=2018&pages=1435-1455&pmid=29940786&doi=10.1080/15548627.2018.1474314&'s revenue stream
- Learn about the earnings of https://doi.org/10.1016/j.molcel.2017.05.032
- Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Mole%20Cell&title=AMPK:%20mechanisms%20of%20cellular%20energy%20sensing%20and%20restoration%20of%20metabolic%20balance&author=D%20Garcia&author=RJ%20Shaw&volume=66&issue=6&publication_year=2017&pages=789-800&pmid=28622524&doi=10.1016/j.molcel.2017.05.032&
- How much does https://doi.org/10.1038/nrm.2017.95 pull in?
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Mole%20Cell%20Biol&title=AMPK:%20guardian%20of%20metabolism%20and%20mitochondrial%20homeostasis&author=S%20Herzig&author=RJ%20Shaw&volume=19&issue=2&publication_year=2018&pages=121-135&pmid=28974774&doi=10.1038/nrm.2017.95&?
- See how much https://doi.org/10.1016/j.bbrc.2009.05.045 makes per month
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Biochem%20Biophys%20Res%20Commun&title=Acetyl-CoA%20carboxylase-%CE%B1%20inhibitor%20TOFA%20induces%20human%20cancer%20cell%20apoptosis&author=C%20Wang&author=C%20Xu&author=M%20Sun&author=D%20Luo&author=D%20Liao&volume=385&issue=3&publication_year=2009&pages=302-306&pmid=19450551&doi=10.1016/j.bbrc.2009.05.045&?
- What is the earnings of https://doi.org/10.1038/nrm3735?
- How much does https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Mole%20Cell%20Biol.&title=Self-consumption:%20the%20interplay%20of%20autophagy%20and%20apoptosis&author=G%20Marino&author=M%20Niso-Santano&author=EH%20Baehrecke&author=G%20Kroemer&volume=15&issue=2&publication_year=2014&pages=81-94&pmid=24401948&doi=10.1038/nrm3735& earn?
- How much does https://doi.org/10.3390/ijms16010924 net monthly?
- https://scholar.google.com/scholar_lookup?journal=Inter%20J%20Mole%20Sci&title=Lipid%20metabolism,%20apoptosis%20and%20cancer%20therapy&author=C%20Huang&author=C%20Freter&volume=16&issue=1&publication_year=2015&pages=924-949&pmid=25561239&doi=10.3390/ijms16010924&'s revenue stream
- How much does https://doi.org/10.1038/nm.4181 net monthly?
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Nat%20Med&title=Inhibition%20of%20acetyl-CoA%20carboxylase%20suppresses%20fatty%20acid%20synthesis%20and%20tumor%20growth%20of%20non-small-cell%20lung%20cancer%20in%20preclinical%20models&author=RU%20Svensson&author=SJ%20Parker&author=LJ%20Eichner&author=MJ%20Kolar&author=M%20Wallace&volume=22&issue=10&publication_year=2016&pages=1108-1109&pmid=27643638&doi=10.1038/nm.4181&?
- https://github.com/ncbi's total income per month
- What is the monthly revenue of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323?
- How much does https://www.nlm.nih.gov/web_policies.html net monthly?
- https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office income
- What's the financial intake of https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- How much does https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal gross monthly?
- What are the total earnings of https://www.nlm.nih.gov/accessibility.html?
- What's the financial gain of https://www.nlm.nih.gov/careers/careers.html?
- What are the total earnings of https://www.nlm.nih.gov/?
- How much money does https://www.nih.gov/ make?
- What's the monthly income of https://www.hhs.gov/?
- How much does https://www.usa.gov/ gross monthly?
Analytics and Tracking {π}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {π}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {π¦}
- Ncbi